Retrospective investigation of the relationship between clinical and laboratory parameters and allergy tests in children with allergic rhinitis
Abstract
Background: It was aimed to investigate the relationship between neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), eosinophil-lymphocyte ratio (ELR), serum total immunoglobulin E (IgE) values and allergy test positivity in patients with allergic rhinitis (AR).
Methods: The study is a descriptive study with a retrospective design. Data on patients aged 0-18 years with a diagnosis of AR were investigated retrospectively. Age, gender, hemogram parameters (leukocyte, eosinophil, lymphocyte, thrombocyte), total IgE values, allergy history and allergy test positivity were evaluated. A p value of less than 0.05 was considered as a statistically significant result.
Results: In the study, the data of 230 pediatric patients with AR were analyzed. The median age of the children was 13 years (10-18). Of the patients 57.4% (n=132) were male, 42.6% (n=98) were female. All laboratory values, except PLR, of the patients with positive allergy test were higher than the patients with negative allergy test. This elevation in WBC, neutrophil, absolute eosinophil, eosinophil percentage, total IgE and ELR values was statistically significant (p<0.05). When the cut-off point for ELR is 0.066; sensitivity was 78.8% and specificity was 70.4%. When the cut-off point for total IgE is 134.5; sensitivity was 75.8%, specificity was 74.1% (p<0.001)
Conclusions: According to study results, 3 out of every 4 patients with positive allergy test can be detected by ELR and total IgE values. Since allergy tests cannot be performed in every clinics, it is extremely important to evaluate the success of more practical and accessible blood tests in predicting allergy test positivity.
Keywords
Allergic rhinitis , children , allergy test , laboratory parameters.
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