The effect of SGLT2 inhibitors on cardio-electrophysiological balance index in diabetic patients with preserved ejection heart failure

Gökhan Gökalp; Nail Burak Özbeyaz

doi:10.47482/acmr.1346676

EN

The effect of SGLT2 inhibitors on cardio-electrophysiological balance index in diabetic patients with preserved ejection heart failure

Abstract

Background: Type 2 diabetes mellitus (DM) increases the risk of heart failure with preserved ejection fraction (HFpEF). The use of sodium-glucose co-transporter-2 (SGLT-2) inhibitors, which have been shown to have cardioprotective effects in HFpEF, has increased in frequency. The index of cardio-electrophysiological balance (iCEB) is a marker that can be calculated on electrocardiography (ECG) and has been proven to be a good predictor of ventricular arrhythmia. This study aimed to investigate the effects of SGLT-2 inhibitors on iCEB and iCEBc in type 2 DM patients with HFpEF. Methods: We retrospectively analyzed the data of 76 patients with type 2 DM with HFpEF who were started on SGLT-2 inhibitors. We compared the ECG parameters obtained at baseline and six-month follow-up. Results: The mean age of the patients included in the study was 64.7±8.9 years. When ECG parameters before and after treatment were compared, iCEB (4.33±1.95 vs. 4.24±1.50, p= 0.006) and iCEBc (4.67±1.35 vs. 4.59±1.36, p<0.001) values were found to be decreased compared to before treatment. Conclusion: The iCEB and iCEBc values of the patients decreased significantly after SGLT-2 inhibitors. These results suggest that SGLT-2 inhibitors may reduce the risk of ventricular arrhythmia in patients with HFpEF.

Keywords

diabetes mellitus , index of cardiac electrophysiological balance , sodium-glucose co-transporter-2 inhibitors , preserved ejection fraction heart failure.

References

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Details

Primary Language

English

Subjects

Intensive Care

Journal Section

Research Article

Authors

Gökhan Gökalp ^*
0000-0002-4958-7266
Türkiye

Nail Burak Özbeyaz
0000-0002-7132-4286
Türkiye

Publication Date

September 27, 2023

Submission Date

August 20, 2023

Acceptance Date

September 7, 2023

Published in Issue

Year 2023 Volume: 4 Number: 3

DOI

https://doi.org/10.47482/acmr.1346676

IZ

https://izlik.org/JA57NG39GR

APA

Gökalp, G., & Özbeyaz, N. B. (2023). The effect of SGLT2 inhibitors on cardio-electrophysiological balance index in diabetic patients with preserved ejection heart failure. Archives of Current Medical Research, 4(3), 192-197. https://doi.org/10.47482/acmr.1346676

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