Molecular pathways of common breast cancer metastases and the distinguishing features of triple-negative breast cancer

Kemal Kürşat Bozkurt; Safiye Aktaş; Merih Güray Durak

doi:10.47482/acmr.1468113

EN

Molecular pathways of common breast cancer metastases and the distinguishing features of triple-negative breast cancer

Abstract

Breast cancer is the most common type of female cancer in Turkey, and metastasis is the most important cause of death, as in other solid organ cancers. Triple-negative tumors constitute 15-20% of breast cancer patients. Within three years after the development of the primary tumor, the tumor spreads to other organs. Breast cancer tends to spread to distant organs, such as bone, liver, brain, lung, and adrenal gland, either through regional lymph nodes or vascular channels. This condition, defined as the tendency to metastasize to specific organs, is called organotropism. Triple-negative breast cancer is a heterogeneous breast cancer subtype showing organotropism for the brain and the lungs. Identifying the molecular changes that may cause tropism for various regions and organs in non-metastatic tumors at the time of diagnosis is vital to developing targeted therapies and achieving longer overall and disease-free survival. In this review, we aimed to summarize the pathogenesis of breast cancer metastasis, the molecular changes involved in the metastatic process, and organotropism, as well as to emphasize the distinguishing features of triple-negative breast cancer in terms of metastatic organotropism.

Keywords

Breast cancer, triple-negative breast cancer, metastasis, molecular pathway, organotropism

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Details

Primary Language

English

Subjects

Pathology

Journal Section

Review

Authors

Kemal Kürşat Bozkurt ^*
0000-0003-1522-9388
Türkiye

Safiye Aktaş
0000-0002-7658-5565
Türkiye

Merih Güray Durak
0000-0003-3516-952X
Türkiye

Publication Date

May 31, 2024

Submission Date

April 14, 2024

Acceptance Date

May 17, 2024

Published in Issue

Year 2024 Volume: 5 Number: 2

DOI

https://doi.org/10.47482/acmr.1468113

IZ

https://izlik.org/JA32CY54SP

APA

Bozkurt, K. K., Aktaş, S., & Durak, M. G. (2024). Molecular pathways of common breast cancer metastases and the distinguishing features of triple-negative breast cancer. Archives of Current Medical Research, 5(2), 50-55. https://doi.org/10.47482/acmr.1468113

AMA

1.Bozkurt KK, Aktaş S, Durak MG. Molecular pathways of common breast cancer metastases and the distinguishing features of triple-negative breast cancer. Arch Curr Med Res. 2024;5(2):50-55. doi:10.47482/acmr.1468113

Chicago

Bozkurt, Kemal Kürşat, Safiye Aktaş, and Merih Güray Durak. 2024. “Molecular Pathways of Common Breast Cancer Metastases and the Distinguishing Features of Triple-Negative Breast Cancer”. Archives of Current Medical Research 5 (2): 50-55. https://doi.org/10.47482/acmr.1468113.

EndNote

Bozkurt KK, Aktaş S, Durak MG (May 1, 2024) Molecular pathways of common breast cancer metastases and the distinguishing features of triple-negative breast cancer. Archives of Current Medical Research 5 2 50–55.

IEEE

[1]K. K. Bozkurt, S. Aktaş, and M. G. Durak, “Molecular pathways of common breast cancer metastases and the distinguishing features of triple-negative breast cancer”, Arch Curr Med Res, vol. 5, no. 2, pp. 50–55, May 2024, doi: 10.47482/acmr.1468113.

ISNAD

Bozkurt, Kemal Kürşat - Aktaş, Safiye - Durak, Merih Güray. “Molecular Pathways of Common Breast Cancer Metastases and the Distinguishing Features of Triple-Negative Breast Cancer”. Archives of Current Medical Research 5/2 (May 1, 2024): 50-55. https://doi.org/10.47482/acmr.1468113.

JAMA

1.Bozkurt KK, Aktaş S, Durak MG. Molecular pathways of common breast cancer metastases and the distinguishing features of triple-negative breast cancer. Arch Curr Med Res. 2024;5:50–55.

MLA

Bozkurt, Kemal Kürşat, et al. “Molecular Pathways of Common Breast Cancer Metastases and the Distinguishing Features of Triple-Negative Breast Cancer”. Archives of Current Medical Research, vol. 5, no. 2, May 2024, pp. 50-55, doi:10.47482/acmr.1468113.

Vancouver

1.Kemal Kürşat Bozkurt, Safiye Aktaş, Merih Güray Durak. Molecular pathways of common breast cancer metastases and the distinguishing features of triple-negative breast cancer. Arch Curr Med Res. 2024 May 1;5(2):50-5. doi:10.47482/acmr.1468113

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https://doi.org/10.1186/s43042-025-00745-0

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