Autonomic dysfunction in cluster headache patients in remission

Dilek İşcan; Huriye Ünlüel; Hilal Özgüner; Adnan Ünalan

doi:10.47482/acmr.1740431

TR EN

Remisyondaki küme başağrısı hastalarında otonomik disfonksiyon

Öz

Arka plan: Küme baş ağrısı (KB), günde sekiz defaya kadar tekrarlayan, 15-180 dakika süren tek taraflı yüz ağrısı atakları ve ipsilateral otonomik özellikler ve huzursuzluktan oluşan primer, trigeminal otonomik baş ağrısıdır. Otonomik semptomlar hem sempatik hem de parasempatik sistem tutulumunun bir sonucu olarak ortaya çıkar. Bu çalışmada, KB hastalarında atak dönemi dışında otonomik tutulumun varlığını araştırmayı amaçladık. Yöntemler: KB'li 19 hastaya remisyon döneminde ve benzer yaş ve cinsiyetteki 19 sağlıklı kontrole Kompozit Otonomik Semptom Skoru (COMPASS-31) uygulandı ve iki grubun yanıtları karşılaştırıldı. Bulgular: KB'li hastalarda remisyon döneminde ortostatik intolerans, sekretomotor ve pupillomotor şikayetlerde artış ve COMPASS-31 toplam skorunda artış görüldü. Sonuç: KB'li hastalarda ortostatik intolerans, sekretomotor ve pupillomotor şikayetlerde artış görüldü. Bu durum, sadece kranial otonomik tutulumun değil, aynı zamanda sistemik otonomik tutulumun da olabileceğini ve bu tutulumun sadece ataklar sırasında olmadığını düşündürmektedir. Çalışmamız, KB grubunda bu şikayetlerin arttığını göstermek için yapılması gereken objektif ve ileri incelemeleri içeren ileri çalışmalara ışık tutacaktır.

Anahtar Kelimeler

Küme başağrısı , ortostatik intolerans , sekretomotor , pupillomotor , COMPASS-31

Autonomic dysfunction in cluster headache patients in remission

Abstract

Background: Cluster headache (CH) is a primary, trigeminal autonomic headache consisting of unilateral attacks of facial pain lasting 15-180 minutes, recurring up to eight times a day, with ipsilateral autonomic features and restlessness. Autonomic symptoms occur as a result of both sympathetic and parasympathetic system involvement. In this study, we aimed to investigate the presence of autonomic involvement in patients with CH interictal period. Methods: The Composite Autonomic Symptom Score-31 (COMPASS-31) was administered to 19 patients with CH during remission and to 19 healthy controls of similar age and sex, and the responses of the two groups were compared. Results: Patients with CH showed orthostatic intolerance, increased secretomotor and pupillomotor complaints and increased COMPASS-31 total score during remission. Conclusions: Patients with CH showed increased orthostatic intolerance, secretomotor and pupillomotor complaints. This suggests that there may be not only cranial autonomic involvement but also systemic autonomic involvement and that this involvement is not only during attacks. Our study will shed light on further studies including objective and advanced investigations that should be performed to show that these complaints are increased in the group with CH.

Keywords

Cluster headache , orthostatic intolerance , secretomotor , pupillomotor , COMPASS-31

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Details

Primary Language

English

Subjects

Pain , Clinical Sciences (Other)

Journal Section

Research Article

Authors

Dilek İşcan ^*
0000-0002-0773-7780
Türkiye

Huriye Ünlüel
0000-0002-6188-8328
Türkiye

Hilal Özgüner
0000-0002-7117-9090
Türkiye

Adnan Ünalan
0000-0002-9187-9713
Türkiye

Publication Date

September 28, 2025

Submission Date

July 11, 2025

Acceptance Date

July 28, 2025

Published in Issue

Year 2025 Volume: 6 Number: 3

DOI

https://doi.org/10.47482/acmr.1740431

IZ

https://izlik.org/JA28NK38MF

APA

İşcan, D., Ünlüel, H., Özgüner, H., & Ünalan, A. (2025). Autonomic dysfunction in cluster headache patients in remission. Archives of Current Medical Research, 6(3), 252-257. https://doi.org/10.47482/acmr.1740431

Archives of Current Medical Research (ACMR) provides instant open access to all content, bearing in mind the fact that presenting research

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http://www.acmronline.org/

Remisyondaki küme başağrısı hastalarında otonomik disfonksiyon

Öz

Anahtar Kelimeler

Autonomic dysfunction in cluster headache patients in remission

Abstract

Keywords

References

Details

Primary Language

Subjects

Journal Section

Authors

Publication Date

Submission Date

Acceptance Date

Published in Issue

DOI

IZ

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