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Roles of the Ratio of C-Reactive Protein to Serum and Pericardial Fluid Albumin Levels in Predicting in-Hospital Mortality in Patients Undergoing Pericardiocentesis

Year 2021, Volume 2, Issue 3, 146 - 152, 22.09.2021


Background: Pericardial effusions occur due to excessive fluid accumulation in the pericardial space. In effusions not responding to medical treatment, pericardiocentesis is an important method of treatment affecting prognosis. CRP/albumin ratios have been found to be associated with prognosis in conditions such as cardiac failure, sepsis, malignancy, and the routinely available parameters used for the prognosis prediction of the patients who underwent pericardiocentesis are limited. This study aimed to examine the usability of CRP/albumin and CRP/pericardial fluid albumin (CRP/pf-albumin) ratios as predictors for in-hospital mortality of patients who underwent surgery pericardiocentesis. Methods: This study included 54 patients (25 females and 29 males). All patients underwent pericardiocentesis. Results: The average age was 67±14 years. When the groups were compared with each other, CRP, CRP/albumin ratio and CRP/ pf-Albumin ratio were higher in the in-hospital mortality group compared to the group discharged with recovery [19 (14-25), 6.3 (1-30), p<0.001; 4.27 (3.87-12.02), 1.9 (0.24-10.38), p<0.001; 7 (6.25-13.59), 2.5 (0.28-12.22), p<0.001, respectively]. In the univariate logistic regression analysis, CRP (odds ratio [OR]: 0.821, P: 0.004, 95.0% confidence interval [CI]: 0.918-1.049), CRP/albumin ratio (OR: 0.600, P: 0.011, 95.0% CI: 0.406-0.888) and CRP/pf-Albumin ratio (OR: 0.608, P: 0.004, 95.0% CI: 0.431-0.856) was found to be associated with in-hospital mortality in patients who underwent pericardiocentesis. Conclusion: For the first time in the literature, we demonstrated that CRP/albumin and CRP/pf-Albumin ratios are associated with in-hospital mortalities in patients who underwent pericardiocentesis, irrespective of the etiology.


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Primary Language English
Subjects Medicine

Uğur KÜÇÜK (Primary Author)
Onsekiz Mart University Faculty of Medicine, Department of Cardiology

Emine GAZİ
Onsekiz Mart University Faculty of Medicine, Department of Cardiology

Onsekiz Mart University Faculty of Medicine, Department of Cardiology

Publication Date September 22, 2021
Application Date February 22, 2021
Acceptance Date August 30, 2021
Published in Issue Year 2021, Volume 2, Issue 3


APA Küçük, U. , Gazi, E. & Kırılmaz, B. (2021). Roles of the Ratio of C-Reactive Protein to Serum and Pericardial Fluid Albumin Levels in Predicting in-Hospital Mortality in Patients Undergoing Pericardiocentesis . Archives of Current Medical Research , 2 (3) , 146-152 . Retrieved from

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