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Effect of the Immunoglobulin G-A-M Treatment on Hepatic Functions and Mortality rates in Patients with Septic Shock

Year 2021, Volume 2, Issue 3, 198 - 203, 22.09.2021

Abstract

Background: In this study, we aimed to explore the effects of conventional sepsis treatment, including classical antibiotherapy and Immunoglubin (Ig) G-A-M combination (Pentaglobin®), on liver function tests and mortality rate in patients with septic shock. Methods: All patients diagnosed with septic shock and treated with Pentaglobin® in the adult intensive care unit of Suleyman Demirel University Practice and Research Hospital between 2005-2013 were retrospectively examined. Demographic properties, age, gender, intensive care treatment duration, general exitus day, the death rate in the first 28 days, general death-survival period, 28th-day death rate, mortality rate, and diagnosis of cases were recorded. Results: At the end of the treatment, it was found that 35 of the cases died, and 35 were transferred to various clinical wards. The overall mortality rate was calculated as 50% from the obtained data. It was found that 40 patients survived in the first 28 dayswhile 30 patients died. In this study, it was observed that Pentaglobin® treatment had no statistically significant impact on ASTALT-Albumin values and mortality rates. Conclusions: However, early diagnosis of sepsis, early initiation of antibiothearpy, early source control, and timely initiation of appropriate fluid therapy play a key role in the succsess of sepsis treatment. For this purpose, as emphasized in the sepsis 3 guideline, we think that raising awareness by physicians and practitioners in the early diagnosis of sepsis is the most important step in the treatment of this clinical condition.

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Details

Primary Language English
Subjects Medicine
Journal Section ORIGINAL ARTICLE
Authors

Ahmet BİNDAL (Primary Author)
Şanlıurfa Education and Research Hospital, Departmant of Adult Intensive Care Unit
0000-0002-1971-6856
Türkiye


Lütfi YAVUZ
University of Health Sciences, Antalya Education and Research Hospital, Departmant of Adult İntensive Care Unit
0000-0002-3542-4773
Türkiye

Publication Date September 22, 2021
Application Date June 24, 2021
Acceptance Date September 3, 2021
Published in Issue Year 2021, Volume 2, Issue 3

Cite

APA Bindal, A. & Yavuz, L. (2021). Effect of the Immunoglobulin G-A-M Treatment on Hepatic Functions and Mortality rates in Patients with Septic Shock . Archives of Current Medical Research , 2 (3) , 198-203 . Retrieved from https://dergipark.org.tr/en/pub/acmr/issue/64942/997204

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