Remisyondaki küme başağrısı hastalarında otonomik disfonksiyon

Year 2025, Volume: 6 Issue: 3, 252 - 257, 28.09.2025

Dilek İşcan , Huriye Ünlüel , Hilal Özgüner , Adnan Ünalan

https://doi.org/10.47482/acmr.1740431

Abstract

Arka plan: Küme baş ağrısı (KB), günde sekiz defaya kadar tekrarlayan, 15-180 dakika süren tek taraflı yüz ağrısı atakları ve ipsilateral otonomik özellikler ve huzursuzluktan oluşan primer, trigeminal otonomik baş ağrısıdır. Otonomik semptomlar hem sempatik hem de parasempatik sistem tutulumunun bir sonucu olarak ortaya çıkar. Bu çalışmada, KB hastalarında atak dönemi dışında otonomik tutulumun varlığını araştırmayı amaçladık.
Yöntemler: KB'li 19 hastaya remisyon döneminde ve benzer yaş ve cinsiyetteki 19 sağlıklı kontrole Kompozit Otonomik Semptom Skoru (COMPASS-31) uygulandı ve iki grubun yanıtları karşılaştırıldı.
Bulgular: KB'li hastalarda remisyon döneminde ortostatik intolerans, sekretomotor ve pupillomotor şikayetlerde artış ve COMPASS-31 toplam skorunda artış görüldü.
Sonuç: KB'li hastalarda ortostatik intolerans, sekretomotor ve pupillomotor şikayetlerde artış görüldü. Bu durum, sadece kranial otonomik tutulumun değil, aynı zamanda sistemik otonomik tutulumun da olabileceğini ve bu tutulumun sadece ataklar sırasında olmadığını düşündürmektedir. Çalışmamız, KB grubunda bu şikayetlerin arttığını göstermek için yapılması gereken objektif ve ileri incelemeleri içeren ileri çalışmalara ışık tutacaktır.

Keywords

Küme başağrısı , ortostatik intolerans , sekretomotor , pupillomotor , COMPASS-31

Autonomic dysfunction in cluster headache patients in remission

Abstract

Background: Cluster headache (CH) is a primary, trigeminal autonomic headache consisting of unilateral attacks of facial pain lasting 15-180 minutes, recurring up to eight times a day, with ipsilateral autonomic features and restlessness. Autonomic symptoms occur as a result of both sympathetic and parasympathetic system involvement. In this study, we aimed to investigate the presence of autonomic involvement in patients with CH interictal period.
Methods: The Composite Autonomic Symptom Score-31 (COMPASS-31) was administered to 19 patients with CH during remission and to 19 healthy controls of similar age and sex, and the responses of the two groups were compared.
Results: Patients with CH showed orthostatic intolerance, increased secretomotor and pupillomotor complaints and increased COMPASS-31 total score during remission.
Conclusions: Patients with CH showed increased orthostatic intolerance, secretomotor and pupillomotor complaints. This suggests that there may be not only cranial autonomic involvement but also systemic autonomic involvement and that this involvement is not only during attacks. Our study will shed light on further studies including objective and advanced investigations that should be performed to show that these complaints are increased in the group with CH.

Keywords

Cluster headache , orthostatic intolerance , secretomotor , pupillomotor , COMPASS-31

Ethical Statement

Ethics Committee Approval Permission to conduct the study was obtained from the Ministry of Health and the Ethics Committee of Non-Invasive Clinical Research Ethics Committee of Niğde Ömer Halisdemir University with protocol number 2024/98 (Date: 9.01.2025).

Supporting Institution

YOK

Thanks

We thank Assistant Professor Nazan Ardıç and Assoc. Prof. Dr. Turgay Demir for their support.

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