Synthesis, Characterization and Biological Activities of Novel a 1,2,3,4-tetrahydroquinazoline and Its Nickel(II) Complexes

Year 2017, Volume: 1 Issue: 1, 11 - 19, 28.12.2017

Alper Çolak , Murat Taş , Gazi İrez Orhan Büyükgüngör , Ferdağ Çolak Handan Günay

https://izlik.org/JA83JL68FD

Abstract

The
2-methyl-2-(1-hydroxyiminoethyl)-1,2,3,4-tetrahydroquinazoline (HL or 1) and its novel Ni(II) complexes, square-planar
[Ni(L)(LH)]·(NO₃) (2) and
octahedral [NiCl₂(LH)(H₂O)₂]·(H₂O) (3), have been synthesized. The ligand and complexes
have been characterized by means of elemental, IR, UV-Vis. spectroscopic
studies, ¹H-NMR, ¹³C-NMR, magnetic susceptibility,
thermal analysis, mass spectroscopy and X-ray diffraction technique. The HL
ligand crystallizes in the P2₁/c. Antimicrobial activity of ligand (1) and complexes (2 and 3) was evaluated by
the agar diffusion method. Complex 2 showed weak antimicrobial activity against
tested microorganism strains. Complex 3 exhibited moderate antimicrobial activity
against Staphylococcus epidermidis
and Candida albicans.

Keywords

antimicrobial activity , nickel complex , oxime , 1 , 2 , 3

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