Conference Paper

Non-linear Analysis of Deformation Behaviour of HA/PLCL Porous Bio-composites

Volume: 5 Number: 1 September 3, 2021
EN

Non-linear Analysis of Deformation Behaviour of HA/PLCL Porous Bio-composites

Abstract

It is well-known that the biology of bone mainly consists of the inorganic minerals, therefore bioceramics with similar constituent to that inorganic minerals of bone, e.g., hydroxyapatite [Ca10(PO4)6(OH)2] (HA) are extensively used for the scaffold fabrication. Recently, biodegradable synthetic polymers (biopolymer) are commonly used as composite materials to enhance the mechanical properties of pure HA porous scaffold. In this present work, HA based scaffold incorporated biopolymer namely, Poly(L-Lactide-co-ε-Caprolactone) (PLCL) is developed in an attempt to overcome the brittleness of pure HA scaffold. Further, two theoretical models are developed to express the non-linearity of the load-displacement curve obtained from the three-point bending test. Finally, the surface morphology of this material is observed using the Scanning Electron Microscopy (SEM). HA/PLCL material is observed to have a non-linear deformation where Model II depicts better accuracy compared to Model I with 9.6% RMS error while 11.61% RMS error for Model I. Due to the overestimation values given by Model I, Model II seems to have a better prediction on the load-displacement curve. The morphological structure of HA/PLCL shows two layers of interconnecting pores where the addition of polymer has enhanced the mechanical properties by providing ductility.

Keywords

References

  1. [1] D. W. Hutmacher and A. J. Garcia, “Scaffold-based bone engineering by using genetically modified cells,” Gene, vol. 347, no. 1. Elsevier, pp. 1–10, Feb. 28, 2005, doi: 10.1016/j.gene.2004.12.040.
  2. [2] A. G. Mikos and J. S. Temenoff, “Formation of highly porous biodegradable scaffolds for tissue engineering,” Electronic Journal of Biotechnology, vol. 3, no. 2, pp. 114–119, 2000, doi: 10.2225/vol3-issue2-fulltext-5.
  3. [3] M. C. Hacker and A. G. Mikos, “Trends in Tissue Engineering Research,” Tissue Engineering, vol. 12, no. 8, pp. 2049–2057, 2006, doi: 10.1089/ten.2006.12.2049.
  4. [4] A. J. Salgado, O. P. Coutinho, and R. L. Reis, “Bone tissue engineering: State of the art and future trends,” Macromolecular Bioscience, vol. 4, no. 8, pp. 743–765, 2004, doi: 10.1002/mabi.200400026.
  5. [5] M. Todo, J. E. Park, H. Kuraoka, J. W. Kim, K. Taki, and M. Ohshima, “Compressive deformation behavior of porous PLLA/PCL polymer blend,” Journal of Materials Science, vol. 44, no. 15, pp. 4191–4194, 2009, doi: 10.1007/s10853-009-3546-0.
  6. [6] M. Todo, P. Yos, T. Arahira, and A. Myoui, “Development and characterization of porous hydroxyapatite scaffolds reinforced with polymeric secondary phase for bone tissue engineering,” Biomaterials and Tissue Technology, vol. 2, no. 1, pp. 1–8, 2018.
  7. [7] M. C. Azevedo, R. L. REIS, M. B. Claase, D. W. Grijpma, and J. Feijen, “Development and properties of polycaprolactone/hydroxyapatite composite biomaterials,” Journal of Material Science. Material in Medicine, vol. 14, no. 2, pp. 103–107, 2003.
  8. [8] V. Guarino et al., “The role of hydroxyapatite as solid signal on performance of PCL porous scaffolds for bone tissue regeneration,” Journal of Biomedical Materials Research Part B : Applied Biomaterials, vol. 86B, no. 2, pp. 548–557, 2008.

Details

Primary Language

English

Subjects

Mechanical Engineering

Journal Section

Conference Paper

Authors

Mitsugu Todo This is me
Japan

Nor Aiman Nor Izmin This is me
Japan

Publication Date

September 3, 2021

Submission Date

October 6, 2020

Acceptance Date

May 21, 2021

Published in Issue

Year 2021 Volume: 5 Number: 1

APA
Mohamad Azahar, F. H., Todo, M., & Nor Izmin, N. A. (2021). Non-linear Analysis of Deformation Behaviour of HA/PLCL Porous Bio-composites. Acta Materialia Turcica, 5(1), 11-17. https://izlik.org/JA38PB42YG
AMA
1.Mohamad Azahar FH, Todo M, Nor Izmin NA. Non-linear Analysis of Deformation Behaviour of HA/PLCL Porous Bio-composites. ACTAMAT. 2021;5(1):11-17. https://izlik.org/JA38PB42YG
Chicago
Mohamad Azahar, Fatin Hazwani, Mitsugu Todo, and Nor Aiman Nor Izmin. 2021. “Non-Linear Analysis of Deformation Behaviour of HA PLCL Porous Bio-Composites”. Acta Materialia Turcica 5 (1): 11-17. https://izlik.org/JA38PB42YG.
EndNote
Mohamad Azahar FH, Todo M, Nor Izmin NA (September 1, 2021) Non-linear Analysis of Deformation Behaviour of HA/PLCL Porous Bio-composites. Acta Materialia Turcica 5 1 11–17.
IEEE
[1]F. H. Mohamad Azahar, M. Todo, and N. A. Nor Izmin, “Non-linear Analysis of Deformation Behaviour of HA/PLCL Porous Bio-composites”, ACTAMAT, vol. 5, no. 1, pp. 11–17, Sept. 2021, [Online]. Available: https://izlik.org/JA38PB42YG
ISNAD
Mohamad Azahar, Fatin Hazwani - Todo, Mitsugu - Nor Izmin, Nor Aiman. “Non-Linear Analysis of Deformation Behaviour of HA PLCL Porous Bio-Composites”. Acta Materialia Turcica 5/1 (September 1, 2021): 11-17. https://izlik.org/JA38PB42YG.
JAMA
1.Mohamad Azahar FH, Todo M, Nor Izmin NA. Non-linear Analysis of Deformation Behaviour of HA/PLCL Porous Bio-composites. ACTAMAT. 2021;5:11–17.
MLA
Mohamad Azahar, Fatin Hazwani, et al. “Non-Linear Analysis of Deformation Behaviour of HA PLCL Porous Bio-Composites”. Acta Materialia Turcica, vol. 5, no. 1, Sept. 2021, pp. 11-17, https://izlik.org/JA38PB42YG.
Vancouver
1.Fatin Hazwani Mohamad Azahar, Mitsugu Todo, Nor Aiman Nor Izmin. Non-linear Analysis of Deformation Behaviour of HA/PLCL Porous Bio-composites. ACTAMAT [Internet]. 2021 Sep. 1;5(1):11-7. Available from: https://izlik.org/JA38PB42YG