Ekstraskeletal Osteosarkom: Olgu Sunumu

Year 2011, , 2 - 3, 01.08.2011

Fisun Ardıç Yükrük Fatma Markoç Ayşe Şerife Salan Berkel Elife Aktaş

https://doi.org/10.5505/aot.2011.17363

Abstract

Extraosseöz osteosarkom (ESOS), yumuşak dokunun osteoid, kemik ya da kondroid materyal üreten malign mezenkimal neoplazmı olarak tanımlanan nadir görülen tümörüdür. Tüm yumuşak doku sarkomlarının %1.2'sini (1), tüm osteosarkomların ise %4'inden azını oluşturur (2,13). Tümör temel olarak retroperiton ve ekstremitelerin yumuşak dokusunda görülür ve kemik ya da periosteum ile ilşkisi yoktur. Kemiğin osteosarkomu ilk iki dekatta görülmesine karşın, ESOS 40 yaşın üzerindeki hastalarda görülür. Meme, deri, mesane, akciğer ve mediasten, dil, spermatik kord ve penis, cerebrum, kolon ESOS'un bildirilmiş olağandışı lokalizasyonlarıdır (3-12).Sunulan olguda histopatolojik olarak epiteloid ve iğsi hücrelerin arasında fokal olarak osteoid üretimi nedeniyle ESOS tanısı verilmiştir.

Keywords

osteosarkom, ekstraosseöz

Extraskeletal Osteosarcoma: A Case Report

Abstract

Extraskeletal osteosarcoma is a rare high grade malign mesenchymal tumor with osteoid, bone and chondroid matrix.It accounts for 1.2 % (1)of all soft tissue tumors and less than 4 % of osteosarcomas (2,13).The tumor occurs principally in soft tissue of retroperitoneum and extremities without any attachment to the underlying bone and periosteum.In contrast to the other subtypes of osteosarcoma which is seen in the first two decades, ESOS most commonly occurs in patients over 40 years old. Breast, skin, bladder, lung and mediastinum, tongue, spermatic cord and penis, cerebrum and colon are other extraordinary localisations of ESOS (3-12).Histopathologically the tumor showed proliferation of epithelioid and spindle shaped tumor cells focally forming lace like osteoid material. Therefore, a definite diagnosis of ESOS was made.

Keywords

osteosarcoma, extraskeletal

References

• Weiss SW, Goldblum JR. Enzinger and Weiss’s Soft Tissue Tumors,fourth edition p:1389-14017
• Lidang Jensen M, Schumacher B, Myhre Jensen O, Sten Osteosarcomas: A clinicopathologic study of 25 cases. Am J Surg Pathol 1998;22:588-94
• Silver SA, Tavassoli FA. Primer osteogenic sarcoma of thebreast: A clinicopathologic analysis of 50 cases. Am J Surg Pathol 1998;22:923-33
• Santos-Juanes J, Galache C, Miralles M, Curto JR, Sanchez del Rio J, Soto J. Primarycutaneous ESOS under a previous electrod essicated actinickeratosis. J AmAcadDematol 2004;51:5166-8
• Olgyai G, Horvath V, Kocsis J, Buza N, Olah A. ESOS in gallbladder. Magy Seb. 2003;56:57-60
• Chapman AD, Pritchard SC, Yap WW, et al. Primary pulmonary osteosarcoma: casereport and molecular analysis. Cancer 2001;91:779-84
• Ulusakarya A, Terrier P, Regnard JF, de Montpreville V, Munck JN. ESOS of the mediastinum after treatment of a mediastinal germ cell tumor. Am J Clin Oncol. 1999;22:609-14
• Loyzaga JM, Fernandez Machin P, Sala J. Osteogenic sarcoma of thetongue. Case report and review of the literature. Pathol Res Pract. 1996;192:75-8
• Bacetic D, Knezevic M, Stojsic Z, Atanackovic M, Vujanic GM. Primary ESOS of the penis with a malignant fibrous histiocytoma-like component. Histopathology 1998;33:185-6
• Cannon TC, Bane BL, Kistler D, et al. Primary intracerebellar osteosarcoma arising within an epidermoid 1998;122:737-9 Pathol Lab Med
• Beiswanger JC, Woodruff RD, Savage PD, Assimos DG,. Primary osteosarcoma of the spermatic cord with synchronous bilateral renal cell carcinoma. Urology 1997:49:957-9
• Shimazu K, Funata N, Yamamoto Y, Mori T. Primary osteosarcoma arising in the colon: report of case. Dis Colon Rectum. 2001;44:1367-70
• Abramovici LC, Hytiroglou P, Klein RM, et al. Well-differantiated ESOS: report of 2 cases, 1 with dedifferentiation. Human Pathology 2005;36:439-43
• Fang Z, Matsumoto S, Keisuke AE, et al. Post radiation soft tissue sarcoma: multi institutional analysis of 14 cases in Japan. J Orthop Sci 2004;9:242-6
• Okada K, Ito H, Miyakoshi N, Sageshima M, Nishida J, Itoi E. A low grade extraskeletal osteosarcoma. Skeletal Radiol 2003;32;165-9
• Fanburg-Smith JC, Bratthauer GL, Miettinen M. Osteocalcin and Osteonectin immunoreactivity in ESOS: A study of 28 cases. Human Pathology 1999;30:32-8