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Sentinel Lymph Node Biopsy in Malignant Melanoma: Current Approaches

Year 2014, , 47 - 52, 01.08.2014
https://doi.org/10.5505/aot.2014.07379

Abstract

Sentinel lymph node biopsy (SLNB) is a staging procedure used to determine the nodal status of patients with melanoma. It has a significantly lower complication rate compared with elective lymph node dissection. SLNB is not recommended for very thin lesions (Breslow thickness ≤ 0.75 mm). The combined lymphatic mapping technique of technetium sulfur colloid with vital blue dye would result in identification of the sentinel node in 99% of patients when performed correctly. SLNB is the single most important prognostic factor in melanoma patients without clinical evidence of nodal metastasis Currently, micrometastatic disease found on SLNB is an indication for completion lymph node dissection. In this review, both current literature and ongoing debates considering SLNB are discussed.

References

  • Dzwierzynski WW. Managing malignant melanoma. Plast Reconstr Surg 2013;132:446e-60e.
  • Eggermont AM, Spatz A, Robert C. Cutaneous melanoma. Lancet 2014;383:816-27.
  • Dunki-Jacobs EM, Callender GG, McMasters KM. Current management of melanoma. Curr Probl Surg 2013;50:351-82.
  • Scolyer RA, Murali R, McCarthy SW, Thompson JF. Pathologic examination of sentinel lymph nodes from melanoma patients. Semin Diagn Pathol 2008;25:100-11.
  • Scolyer RA, Thompson JF, Stretch JR, Sharma R, McCarthy SW. Pathology of melanocytic lesions: new, controversial, and clinically important issues. J Surg Oncol 2004;86:200-11.
  • Eigentler TK, Buettner PG, Leiter U, Garbe C. Impact of ulceration in stages I to III cutaneous melanoma as staged by the American Joint Committee on Cancer Staging System: an analysis of the German Central Malignant Melanoma Registry. J Clin Oncol 2004;22:4376-83.
  • Balch CM, Soong SJ, Gershenwald JE, et al. Prognostic factors analysis of 17,600 melanoma patients: Committee on Cancer melanoma staging system. J Clin Oncol 2001;19:3622-34. the American Joint
  • Morton DL, Wen DR, Wong JH, et al. Technical details of intraoperative lymphatic mapping for early stage melanoma. Arch Surg 1992;127:392-9.
  • Glass LF, Messina JL, Cruse W, et al. The use of intraoperative radiolymphoscintigraphy for sentinel node biopsy in patients with malignant melanoma. Dermatol Surg 1996;22:715-20.
  • Gershenwald JE, Thompson W, Mansfield PF, et al. Multi-institutional melanoma lymphatic mapping experience: the prognostic value of sentinel lymph node status in 612 stage I or II melanoma patients. J Clin Oncol 1999;17:976-83.
  • Murali R, Haydu LE, Long GV, et al. Clinical and pathologic factors associated with distant metastasis and survival in patients with thin primary cutaneous melanoma. Ann Surg Oncol 2012;19:1782-9.
  • Faries MB, Wanek LA, Elashoff D, Wright BE, Morton DL. Predictors of occult nodal metastasis in patients 2010;145:137-42. Arch Surg
  • Kesmodel SB, Karakousis GC, Botbyl JD, et al. Mitotic rate as a predictor of sentinel lymph node positivity in patients with thin melanomas. Ann Surg Oncol 2005;12:449-58.
  • Balch CM, Gershenwald JE, Soong SJ, et al. Final version of 2009 AJCC melanoma staging and classification. J Clin Oncol 2009;27:6199-206.
  • Gajdos C, Griffith KA, Wong SL, et al. Is there a benefit to sentinel lymph node biopsy in patients with T4 melanoma? Cancer 2009;115:5752-60.
  • Sugarbaker EV, McBride CM. Melanoma of the trunk: the results of surgical excision and anatomic guidelines for predicting nodal metastasis. Surgery 1976;80:22-30.
  • McMasters KM, Chao C, Wong SL, et al. Interval sentinel lymph nodes in melanoma. Arch Surg 2002;137:543-7; discussion 7-9.
  • Gershenwald JE, Tseng CH, Thompson W, et al. Improved sentinel lymph node localization in patients with primary melanoma with the use of radiolabeled colloid. Surgery 1998;124:203-10.
  • Jansen L, Nieweg OE, Kapteijn AE, et al. Reliability of lymphoscintigraphy in indicating the number of sentinel nodes in melanoma patients. Ann Surg Oncol 2000;7:624-30.
  • Spanheimer PM, Graham MM, Sugg SL, Scott- Conner CE, Weigel RJ. Measurement of uterine radiation indicates safety of sentinel lymph node biopsy during pregnancy. Ann Surg Oncol 2009;16:1143-7.
  • 28. Soo V1, Shen P, Pichardo R, Azzazy H, Stewart JH, Geisinger KR, Levine EA. Intraoperative evaluation of sentinel lymph nodes for metastatic melanoma by imprint cytology. Ann Surg Oncol. 2007 May;14(5): 1612-7. Epub 2007 Feb 9
  • 29. Spanheimer PM, Graham MM, Sugg SL, Scott- Conner CE, Weigel RJ. Measurement of uterine radiation indicates safety of sentinel lymph node biopsy during pregnancy. Ann Surg Oncol 2009;16:1143-7.

Malign Melanomda Sentinel Lenf Nodu Biyopsisi: Güncel Yaklaşımlar

Year 2014, , 47 - 52, 01.08.2014
https://doi.org/10.5505/aot.2014.07379

Abstract

Sentinel lenf nodu biyopsisi (SLNB), malign melanomalı hastaların lenf nodlarının durumunu belirlemek için kullanılan bir evreleme prosedürüdür. Elektif lenf nodu diseksiyonuna göre çok daha az komplikasyon riski bulunmaktadır. SLNB, Breslow kalınlığı

References

  • Dzwierzynski WW. Managing malignant melanoma. Plast Reconstr Surg 2013;132:446e-60e.
  • Eggermont AM, Spatz A, Robert C. Cutaneous melanoma. Lancet 2014;383:816-27.
  • Dunki-Jacobs EM, Callender GG, McMasters KM. Current management of melanoma. Curr Probl Surg 2013;50:351-82.
  • Scolyer RA, Murali R, McCarthy SW, Thompson JF. Pathologic examination of sentinel lymph nodes from melanoma patients. Semin Diagn Pathol 2008;25:100-11.
  • Scolyer RA, Thompson JF, Stretch JR, Sharma R, McCarthy SW. Pathology of melanocytic lesions: new, controversial, and clinically important issues. J Surg Oncol 2004;86:200-11.
  • Eigentler TK, Buettner PG, Leiter U, Garbe C. Impact of ulceration in stages I to III cutaneous melanoma as staged by the American Joint Committee on Cancer Staging System: an analysis of the German Central Malignant Melanoma Registry. J Clin Oncol 2004;22:4376-83.
  • Balch CM, Soong SJ, Gershenwald JE, et al. Prognostic factors analysis of 17,600 melanoma patients: Committee on Cancer melanoma staging system. J Clin Oncol 2001;19:3622-34. the American Joint
  • Morton DL, Wen DR, Wong JH, et al. Technical details of intraoperative lymphatic mapping for early stage melanoma. Arch Surg 1992;127:392-9.
  • Glass LF, Messina JL, Cruse W, et al. The use of intraoperative radiolymphoscintigraphy for sentinel node biopsy in patients with malignant melanoma. Dermatol Surg 1996;22:715-20.
  • Gershenwald JE, Thompson W, Mansfield PF, et al. Multi-institutional melanoma lymphatic mapping experience: the prognostic value of sentinel lymph node status in 612 stage I or II melanoma patients. J Clin Oncol 1999;17:976-83.
  • Murali R, Haydu LE, Long GV, et al. Clinical and pathologic factors associated with distant metastasis and survival in patients with thin primary cutaneous melanoma. Ann Surg Oncol 2012;19:1782-9.
  • Faries MB, Wanek LA, Elashoff D, Wright BE, Morton DL. Predictors of occult nodal metastasis in patients 2010;145:137-42. Arch Surg
  • Kesmodel SB, Karakousis GC, Botbyl JD, et al. Mitotic rate as a predictor of sentinel lymph node positivity in patients with thin melanomas. Ann Surg Oncol 2005;12:449-58.
  • Balch CM, Gershenwald JE, Soong SJ, et al. Final version of 2009 AJCC melanoma staging and classification. J Clin Oncol 2009;27:6199-206.
  • Gajdos C, Griffith KA, Wong SL, et al. Is there a benefit to sentinel lymph node biopsy in patients with T4 melanoma? Cancer 2009;115:5752-60.
  • Sugarbaker EV, McBride CM. Melanoma of the trunk: the results of surgical excision and anatomic guidelines for predicting nodal metastasis. Surgery 1976;80:22-30.
  • McMasters KM, Chao C, Wong SL, et al. Interval sentinel lymph nodes in melanoma. Arch Surg 2002;137:543-7; discussion 7-9.
  • Gershenwald JE, Tseng CH, Thompson W, et al. Improved sentinel lymph node localization in patients with primary melanoma with the use of radiolabeled colloid. Surgery 1998;124:203-10.
  • Jansen L, Nieweg OE, Kapteijn AE, et al. Reliability of lymphoscintigraphy in indicating the number of sentinel nodes in melanoma patients. Ann Surg Oncol 2000;7:624-30.
  • Spanheimer PM, Graham MM, Sugg SL, Scott- Conner CE, Weigel RJ. Measurement of uterine radiation indicates safety of sentinel lymph node biopsy during pregnancy. Ann Surg Oncol 2009;16:1143-7.
  • 28. Soo V1, Shen P, Pichardo R, Azzazy H, Stewart JH, Geisinger KR, Levine EA. Intraoperative evaluation of sentinel lymph nodes for metastatic melanoma by imprint cytology. Ann Surg Oncol. 2007 May;14(5): 1612-7. Epub 2007 Feb 9
  • 29. Spanheimer PM, Graham MM, Sugg SL, Scott- Conner CE, Weigel RJ. Measurement of uterine radiation indicates safety of sentinel lymph node biopsy during pregnancy. Ann Surg Oncol 2009;16:1143-7.
There are 22 citations in total.

Details

Primary Language Turkish
Journal Section Articles
Authors

Hakan Uzun This is me

Ozan Bitik This is me

Publication Date August 1, 2014
Published in Issue Year 2014

Cite

APA Uzun, H. ., & Bitik, O. . (2014). Malign Melanomda Sentinel Lenf Nodu Biyopsisi: Güncel Yaklaşımlar. Acta Oncologica Turcica, 47(2), 47-52. https://doi.org/10.5505/aot.2014.07379
AMA Uzun H, Bitik O. Malign Melanomda Sentinel Lenf Nodu Biyopsisi: Güncel Yaklaşımlar. Acta Oncologica Turcica. August 2014;47(2):47-52. doi:10.5505/aot.2014.07379
Chicago Uzun, Hakan, and Ozan Bitik. “Malign Melanomda Sentinel Lenf Nodu Biyopsisi: Güncel Yaklaşımlar”. Acta Oncologica Turcica 47, no. 2 (August 2014): 47-52. https://doi.org/10.5505/aot.2014.07379.
EndNote Uzun H, Bitik O (August 1, 2014) Malign Melanomda Sentinel Lenf Nodu Biyopsisi: Güncel Yaklaşımlar. Acta Oncologica Turcica 47 2 47–52.
IEEE H. . Uzun and O. . Bitik, “Malign Melanomda Sentinel Lenf Nodu Biyopsisi: Güncel Yaklaşımlar”, Acta Oncologica Turcica, vol. 47, no. 2, pp. 47–52, 2014, doi: 10.5505/aot.2014.07379.
ISNAD Uzun, Hakan - Bitik, Ozan. “Malign Melanomda Sentinel Lenf Nodu Biyopsisi: Güncel Yaklaşımlar”. Acta Oncologica Turcica 47/2 (August 2014), 47-52. https://doi.org/10.5505/aot.2014.07379.
JAMA Uzun H, Bitik O. Malign Melanomda Sentinel Lenf Nodu Biyopsisi: Güncel Yaklaşımlar. Acta Oncologica Turcica. 2014;47:47–52.
MLA Uzun, Hakan and Ozan Bitik. “Malign Melanomda Sentinel Lenf Nodu Biyopsisi: Güncel Yaklaşımlar”. Acta Oncologica Turcica, vol. 47, no. 2, 2014, pp. 47-52, doi:10.5505/aot.2014.07379.
Vancouver Uzun H, Bitik O. Malign Melanomda Sentinel Lenf Nodu Biyopsisi: Güncel Yaklaşımlar. Acta Oncologica Turcica. 2014;47(2):47-52.