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Testiküler Feminizasyon Sendromunda Gelişen Seminoma: Hastanın 7 Yıllık Takibi

Year 2008, Volume: 41 Issue: 1, 57 - 58, 01.04.2008

Abstract

This is a case of a young woman who had testicular feminization and deveioped a seminoma in an undescended testis. This patient admitted to the gynecology service with the complaint of primary amenorrhea. Cytogenetic analysis of chromoso-mes from blood demonstrated a 46, XY karyotype. At iaparoscopy a strict structure beieived to be uterus was noted. The right gonad was found 10x15 mm in size, solid, fusiform, on the pelvic sidewall. There was no left gonad. The procedure was ter-minated following right gonodectomy. Pathology had reported the result as seminoma deveioped in the atrophic testis. She trea-ted with irradiation lor a total dose of 26 Gy in 2 Gy daily fractions by using 6 İ/İV photons of linear accelerator. No recurrence has been found during the postoperative foiiow-up period of 7 years.

References

  • Morris JM. The syndrome of testicular feminization in male pseudohermaphrodites. Am J Obstet Gynecol 1953; 65:1192-211.
  • Batata MA, VVhitmore WF Jr, Chu FC, et al. Cryptorchidism
  • and testicular cancer. J Urol. 1980;124:382-7
  • lwamotoa I, Yanazumea S, Fujinob T, Yyoshiokac T,
  • Douchia T. Leydig celi tumor in an elderly patient vvith com- plete androgen insensitivity syndrome. Gynecologic Oncology 2005;96:870-2.
  • Griffin JE. Androgen resistance - the clinical and molecular
  • spectrum. N Engl J Med 1992;326:611-8.
  • Ross GT. Disorders o f the ovary and female reproductive
  • tract. İn: VVilson JD, Foster DW (eds). Williams Textbook of Endocrinology, 7lh ed. Philadelphia: WB Saunders 1985; 206-258.
  • Joanne L, Rutgers J, Robert ES. The androgen insensitivity
  • syndrome (testicular feminization). A clinicopathologic study o f 43 Cases. Int J Gynecol Pathl 1991 ;10:126-44.
  • Sakai N, Yamada T, Baba M, et al. Bilateral testicular tumors in androgen insensitivity syndrome Int. J. Urol 2000;7:390-2.
  • Muiler J. Skakkebaek NE. Testicular carcinoma in situ in children vvith androgen insensitivity (testicular feminization). B r Med J 1984; 288:1419-20. 58

Seminoma in A Case of Testicular Feminization Syndrome: Patient Outcome After 7 Years of Follow-up

Year 2008, Volume: 41 Issue: 1, 57 - 58, 01.04.2008

Abstract

Bu çalışmada, testiküler feminizasyon tanısı konan ve inmemiş testiste seminom gelişmiş 23 yaşında bir hasta bildirilmiştir. Kandan alınan kromozomların sitogenetik analizinde 46 XY karyotipi bulundu. Laparoskopide uterus olduğu düşünülen sert bir yapı bulundu. Sağ gonad pelvik duvar içerisinde 10 X 15 mm ebadında, fusiform, solid kitle olarak bulundu. Sol gonad yoktu. Sağ gonadektomi uygulandı. Patoloji atrofik testisten gelişen seminoma sonucu olarak rapor edildi. Hasta 6 MV foton LINAC kullanılarak günde 2 Gy fraksiyon ile toplam 26 Gy ışınlandı. Bu seminoma olgusu operasyon sonrası 7 yıl nüksetmemiş olarak takip edildi.

References

  • Morris JM. The syndrome of testicular feminization in male pseudohermaphrodites. Am J Obstet Gynecol 1953; 65:1192-211.
  • Batata MA, VVhitmore WF Jr, Chu FC, et al. Cryptorchidism
  • and testicular cancer. J Urol. 1980;124:382-7
  • lwamotoa I, Yanazumea S, Fujinob T, Yyoshiokac T,
  • Douchia T. Leydig celi tumor in an elderly patient vvith com- plete androgen insensitivity syndrome. Gynecologic Oncology 2005;96:870-2.
  • Griffin JE. Androgen resistance - the clinical and molecular
  • spectrum. N Engl J Med 1992;326:611-8.
  • Ross GT. Disorders o f the ovary and female reproductive
  • tract. İn: VVilson JD, Foster DW (eds). Williams Textbook of Endocrinology, 7lh ed. Philadelphia: WB Saunders 1985; 206-258.
  • Joanne L, Rutgers J, Robert ES. The androgen insensitivity
  • syndrome (testicular feminization). A clinicopathologic study o f 43 Cases. Int J Gynecol Pathl 1991 ;10:126-44.
  • Sakai N, Yamada T, Baba M, et al. Bilateral testicular tumors in androgen insensitivity syndrome Int. J. Urol 2000;7:390-2.
  • Muiler J. Skakkebaek NE. Testicular carcinoma in situ in children vvith androgen insensitivity (testicular feminization). B r Med J 1984; 288:1419-20. 58
There are 13 citations in total.

Details

Primary Language Turkish
Journal Section Articles
Authors

Yıldız Güney This is me

Meltem Nalça Andrıeu This is me

Ayşe Hiçsözmez This is me

Caner Aktaş This is me

Cengiz Kurtman This is me

Şaban Çakır Gökçe This is me

Publication Date April 1, 2008
Published in Issue Year 2008 Volume: 41 Issue: 1

Cite

APA Güney, Y. ., Andrıeu, M. N. ., Hiçsözmez, A. ., Aktaş, C. ., et al. (2008). Seminoma in A Case of Testicular Feminization Syndrome: Patient Outcome After 7 Years of Follow-up. Acta Oncologica Turcica, 41(1), 57-58.
AMA Güney Y, Andrıeu MN, Hiçsözmez A, Aktaş C, Kurtman C, Gökçe ŞÇ. Seminoma in A Case of Testicular Feminization Syndrome: Patient Outcome After 7 Years of Follow-up. Acta Oncologica Turcica. April 2008;41(1):57-58.
Chicago Güney, Yıldız, Meltem Nalça Andrıeu, Ayşe Hiçsözmez, Caner Aktaş, Cengiz Kurtman, and Şaban Çakır Gökçe. “Seminoma in A Case of Testicular Feminization Syndrome: Patient Outcome After 7 Years of Follow-up”. Acta Oncologica Turcica 41, no. 1 (April 2008): 57-58.
EndNote Güney Y, Andrıeu MN, Hiçsözmez A, Aktaş C, Kurtman C, Gökçe ŞÇ (April 1, 2008) Seminoma in A Case of Testicular Feminization Syndrome: Patient Outcome After 7 Years of Follow-up. Acta Oncologica Turcica 41 1 57–58.
IEEE Y. . Güney, M. N. . Andrıeu, A. . Hiçsözmez, C. . Aktaş, C. . Kurtman, and Ş. Ç. . Gökçe, “Seminoma in A Case of Testicular Feminization Syndrome: Patient Outcome After 7 Years of Follow-up”, Acta Oncologica Turcica, vol. 41, no. 1, pp. 57–58, 2008.
ISNAD Güney, Yıldız et al. “Seminoma in A Case of Testicular Feminization Syndrome: Patient Outcome After 7 Years of Follow-up”. Acta Oncologica Turcica 41/1 (April 2008), 57-58.
JAMA Güney Y, Andrıeu MN, Hiçsözmez A, Aktaş C, Kurtman C, Gökçe ŞÇ. Seminoma in A Case of Testicular Feminization Syndrome: Patient Outcome After 7 Years of Follow-up. Acta Oncologica Turcica. 2008;41:57–58.
MLA Güney, Yıldız et al. “Seminoma in A Case of Testicular Feminization Syndrome: Patient Outcome After 7 Years of Follow-up”. Acta Oncologica Turcica, vol. 41, no. 1, 2008, pp. 57-58.
Vancouver Güney Y, Andrıeu MN, Hiçsözmez A, Aktaş C, Kurtman C, Gökçe ŞÇ. Seminoma in A Case of Testicular Feminization Syndrome: Patient Outcome After 7 Years of Follow-up. Acta Oncologica Turcica. 2008;41(1):57-8.