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Bir Akut Promiyelositik Lösemi Olgusunda "All-Trans Retinoic Acid (ATRA)" Tedavisi Sırasında Ağrısız Skrotal Ülser

Year 2009, Volume: 42 Issue: 1, 24 - 26, 01.04.2009

Müyesser Saykı Meltem Yüksel Şule Mine Bakanay Mutlu Arat

Abstract

Acute promyelocytic leukemia (APL), acute myeloblastik leukemia (AML) M3 according to FAB classification is a distinct subtype of AML usuaily characterized by hypergranular leukemic cells, bleeding diathesis and a spesific translocation t(15:17) vvhich plays a pivotal role in the pathogenesis of APL. The gold Standard therapy in APL is all-trans retinoic acid (ATRA) containing combinations. Despite possible significant side effects, ATRA is well tolerated. We report on a 50-year-old man vvith APL who developed scrotal ulcerations during treatment vvith ATRA. Although there are few case reports, to our knovvledge this case is the first one that has painless scrotal ulcerations related vvith ATRA.

Keywords

Acute promyelocytic leukemia all-trans retinoic acid scrotal ulcer.

References

  • Ghaddar H, Anderlini P, Estey E. Treatment of acute myelo- genous leukemia. N Engl J Med 1995;332:1717-8.
  • Sanz M, Talimarı M, Lo-Coco F, et a l Tricks of the trade for the appropriate management of new y diagnosed acute promyelocytic leukemia. Blood 2005;105:3019-25.
  • Koga H, Fujita I, Miyazaki S. Effects of all-trans-retinoic acid on superoxide generation in intact neutrophils and a cell- free system. Br J Haematol 1997;97:300-5.
  • Raymond PW, Hugues de The, Wang ZY, Degos L. Acute promyelocytic leukemia. N Engl J Med 1993;329:177-89.
  • Astudillo L, Loche F, Reynish W, et al. Sweet’s syndrome associated with retinoic acid syndrome in a patient with promyelocytic leukemia: Case report. Ann Hematol 2002; 81:111-4. 2 5
  • Bir Akut Promiyelositik Lösemi Olgusunda ‘‘All-Trans Retinoic Acid (ATRA)” Tedavisi Sırasında Ağrısız Skrotal Ülser
  • Longacre TA, Smoller BR. Leukemia cutis. Analysis of 50 biopsy-proven cases with an emphasis on occurrence in myelodysplastic syndromes. Am J Clin Pathol 1993;100: 276-84.
  • Gettinger S, Shapira I, Sheinfeld N, Grossbard M. Complications of therapy in cancer patients: Case 2. Scrotal uiceration during all-trans-retinoic acid therapy for acute promyelocytic leukemia. J Clin Oncoi 2004;22:4648-9.
  • Charles K, Kana M, VVİnfield D, Reitty J. Scrotal uiceration during ali trans retinoic (ATRA) therapy for acute promye­ locytic leukaemia. Clin Lab Haem 2000;22:171-4.
  • Mourad YA, Jabr F, Salem Z. Scrotal uiceration induced by all-trans-retinoic acid in a patient with acute promyelocytic leukemia. Int J Dermatol 2005;44:68-9.
  • Pavitron K, Arjun R, Aruna R, Thomas M. Scrotal uiceration during induction therapy of acute promyelocytic leukemia with ATRA. Am J Hematol 2004;75:260-1.
  • Fukuno K, Tsurumi H, Goto H, et al. Genitat ulcers during treatment with all-trans retinoic acid for acute promyelocytic leukemia. Leuk Lymphoma 2003;44:2009-13.
  • Tajima K, Sagae M, YahagiA, et al. Scrotum exfoliative der- matitis with ulcers associated with treatment of with all-trans retinoic acid. Rinsho Ketsueki 1998;39:48-52.
  • Mori A, Tamura S, Katsuna T, et al. Scrotal ulcer occuring with acute promyelocytic leukemia during treatment with all- trans retinoic acid. Oncoi Rep1999;6:55-8.
  • Kuo M, Dunn P, Wu H, Shih L. Ali trans retinic acid induced erythema nodosum in patients with acute promyelocytic leu­ kemia. Ann Hematol 2004;83:376-80.

Painless Scrotal Ulcer During All-Trans Retinoic Acid (ATRA) Treatment foran Acute Promyelocitic Leukemia Case

Year 2009, Volume: 42 Issue: 1, 24 - 26, 01.04.2009

Müyesser Saykı Meltem Yüksel Şule Mine Bakanay Mutlu Arat

Abstract

FAB sınıflamasına göre akut miyeloblastik lösemi (AML) M3 olarak adlandırılan akut promiyelositik lösemi (APL), akut miyeloblastik löseminin genellikle hipergranüler lösemik hücreler, kanama eğilimi ve patogenezde önemli rol alan t(15,17) ile karakterize bir alt tipidir. APL 'de altın standart tedavi "all-trans retinoic acid (ATRA)" içeren kombinasyonlardır. ATRA, olası önemli yan etkilerine rağmen iyi tolere edilmektedir. Bu olguda, AML tanısı alan ve ATRA tedavisi sırasında skrotal ülser gelişen 50 yaşında bir erkek hasta bildirilmektedir. Literatürde ATRA ilişkili birkaç skrotal ülser olgusu bulunmakla birlikte araştırmalarımıza göre ağrısız karakterde bildirilen ilk olgudur.

Keywords

Akut promyelositik lösemi "all-trans" retinoik asit skrotal ülser.

References

  • Ghaddar H, Anderlini P, Estey E. Treatment of acute myelo- genous leukemia. N Engl J Med 1995;332:1717-8.
  • Sanz M, Talimarı M, Lo-Coco F, et a l Tricks of the trade for the appropriate management of new y diagnosed acute promyelocytic leukemia. Blood 2005;105:3019-25.
  • Koga H, Fujita I, Miyazaki S. Effects of all-trans-retinoic acid on superoxide generation in intact neutrophils and a cell- free system. Br J Haematol 1997;97:300-5.
  • Raymond PW, Hugues de The, Wang ZY, Degos L. Acute promyelocytic leukemia. N Engl J Med 1993;329:177-89.
  • Astudillo L, Loche F, Reynish W, et al. Sweet’s syndrome associated with retinoic acid syndrome in a patient with promyelocytic leukemia: Case report. Ann Hematol 2002; 81:111-4. 2 5
  • Bir Akut Promiyelositik Lösemi Olgusunda ‘‘All-Trans Retinoic Acid (ATRA)” Tedavisi Sırasında Ağrısız Skrotal Ülser
  • Longacre TA, Smoller BR. Leukemia cutis. Analysis of 50 biopsy-proven cases with an emphasis on occurrence in myelodysplastic syndromes. Am J Clin Pathol 1993;100: 276-84.
  • Gettinger S, Shapira I, Sheinfeld N, Grossbard M. Complications of therapy in cancer patients: Case 2. Scrotal uiceration during all-trans-retinoic acid therapy for acute promyelocytic leukemia. J Clin Oncoi 2004;22:4648-9.
  • Charles K, Kana M, VVİnfield D, Reitty J. Scrotal uiceration during ali trans retinoic (ATRA) therapy for acute promye­ locytic leukaemia. Clin Lab Haem 2000;22:171-4.
  • Mourad YA, Jabr F, Salem Z. Scrotal uiceration induced by all-trans-retinoic acid in a patient with acute promyelocytic leukemia. Int J Dermatol 2005;44:68-9.
  • Pavitron K, Arjun R, Aruna R, Thomas M. Scrotal uiceration during induction therapy of acute promyelocytic leukemia with ATRA. Am J Hematol 2004;75:260-1.
  • Fukuno K, Tsurumi H, Goto H, et al. Genitat ulcers during treatment with all-trans retinoic acid for acute promyelocytic leukemia. Leuk Lymphoma 2003;44:2009-13.
  • Tajima K, Sagae M, YahagiA, et al. Scrotum exfoliative der- matitis with ulcers associated with treatment of with all-trans retinoic acid. Rinsho Ketsueki 1998;39:48-52.
  • Mori A, Tamura S, Katsuna T, et al. Scrotal ulcer occuring with acute promyelocytic leukemia during treatment with all- trans retinoic acid. Oncoi Rep1999;6:55-8.
  • Kuo M, Dunn P, Wu H, Shih L. Ali trans retinic acid induced erythema nodosum in patients with acute promyelocytic leu­ kemia. Ann Hematol 2004;83:376-80.
There are 15 citations in total.

Details

Primary Language Turkish
Journal Section Articles
Authors

Müyesser Saykı This is me

Meltem Yüksel This is me

Şule Mine Bakanay This is me

Mutlu Arat This is me

Publication Date April 1, 2009
Published in Issue Year 2009 Volume: 42 Issue: 1

Cite

APA Saykı, M. ., Yüksel, M. ., Bakanay, Ş. M. ., Arat, M. . (2009). Painless Scrotal Ulcer During All-Trans Retinoic Acid (ATRA) Treatment foran Acute Promyelocitic Leukemia Case. Acta Oncologica Turcica, 42(1), 24-26.
AMA Saykı M, Yüksel M, Bakanay ŞM, Arat M. Painless Scrotal Ulcer During All-Trans Retinoic Acid (ATRA) Treatment foran Acute Promyelocitic Leukemia Case. Acta Oncologica Turcica. April 2009;42(1):24-26.
Chicago Saykı, Müyesser, Meltem Yüksel, Şule Mine Bakanay, and Mutlu Arat. “Painless Scrotal Ulcer During All-Trans Retinoic Acid (ATRA) Treatment Foran Acute Promyelocitic Leukemia Case”. Acta Oncologica Turcica 42, no. 1 (April 2009): 24-26.
EndNote Saykı M, Yüksel M, Bakanay ŞM, Arat M (April 1, 2009) Painless Scrotal Ulcer During All-Trans Retinoic Acid (ATRA) Treatment foran Acute Promyelocitic Leukemia Case. Acta Oncologica Turcica 42 1 24–26.
IEEE M. . Saykı, M. . Yüksel, Ş. M. . Bakanay, and M. . Arat, “Painless Scrotal Ulcer During All-Trans Retinoic Acid (ATRA) Treatment foran Acute Promyelocitic Leukemia Case”, Acta Oncologica Turcica, vol. 42, no. 1, pp. 24–26, 2009.
ISNAD Saykı, Müyesser et al. “Painless Scrotal Ulcer During All-Trans Retinoic Acid (ATRA) Treatment Foran Acute Promyelocitic Leukemia Case”. Acta Oncologica Turcica 42/1 (April 2009), 24-26.
JAMA Saykı M, Yüksel M, Bakanay ŞM, Arat M. Painless Scrotal Ulcer During All-Trans Retinoic Acid (ATRA) Treatment foran Acute Promyelocitic Leukemia Case. Acta Oncologica Turcica. 2009;42:24–26.
MLA Saykı, Müyesser et al. “Painless Scrotal Ulcer During All-Trans Retinoic Acid (ATRA) Treatment Foran Acute Promyelocitic Leukemia Case”. Acta Oncologica Turcica, vol. 42, no. 1, 2009, pp. 24-26.
Vancouver Saykı M, Yüksel M, Bakanay ŞM, Arat M. Painless Scrotal Ulcer During All-Trans Retinoic Acid (ATRA) Treatment foran Acute Promyelocitic Leukemia Case. Acta Oncologica Turcica. 2009;42(1):24-6.