BibTex RIS Cite

Modifiye Radikal Mastektomi Operasyonlarında Postoperatif Analjezi Amaçlı Uygulanan İntravenöz Parasetamolün Morfin Tüketimi Üzerine Etkisi

Year 2009, Volume: 42 Issue: 3, 100 - 104, 01.12.2009

Abstract

Paracetamol is combined with opioids or used alone for management of post-operative pain. İn this study, we investigated the effect of intravenous (IV) paracetamol on morphine consumption used for post-operative pain after modified radical mastectomy. SixtyASA l-lll patients scheduled for modified radical mastectomy under general anesthesia were randomly allocated into two groups by using closed envelope system (Group P; n= 30, Group S; n= 30). Anesthesia was induced with fentanil 1-2/vg/kg, cisatracurium 0.15 mg/kg and propofol 2-2.5 mg/kg, maintained with sevoflurane 1-2%, N20 66%/Oz. Group P received paracetamol 1 g, infused in 15 minutes one hour before the end of surgery and at six hours intervals in post-operative 24 hours. Şaline infusion was given to Group S at the same time. Ali patients were connected to a patient controlled analgesia device adjusted to deliver morphine 5 mg as loading, 1 mg bolus and five minutes lock-out time. A bolus of morphine 5 mg was administered if visu-al analog scale (VAS) s 4. l/AS scores, sedation, respiratory rate, heart rate, blood pressure, Sp02, morphine consumption and side effects were recorded. Demographic parameters were similar. Morphine consumption was less in Group P (p< 0.001). The demand and delivery doses of morphine was higher in Group S (p< 0.001). VAS scores were lower in paracetamol group (p< 0.008). Aithough the side effects such as nausea-vomiting, urinary retention and itching were more in Group S, it was not sta-tistically significant. İn this study, aithough statistically not significant, we have demonstrated that paracetamol used for post-operative pain can reduce morphine consumption and side effects while providing an effective analgesia.

References

  • Eti Z Postoperatif ağrı tedavisi. Erdine S (editör). Ağrı. 3. Baskı. İstanbul: Nobei Matbaacılık, 2007:150-73.
  • Peduto VA, Ballabio M, Stefanini S. Efficacy of propaceta- mol in the treatment of postoperative pain. Morphine spa- ring effect in orthopedic surgery. Italian Colloborative Group on Propacetamol. Açta Anaesthesiol Scand 1998;42:293-8.
  • Holmer Petterson P, Owall A, Jakobsson J. Early bioavaila
  • bility of paracetamoi after oral or intravenous administration. Açta Anaesthesiol Scand 2004;48:867-70.
  • Bonica JJ. Postoperative pain. İn: Bonica JJ (ed). The management of Pain. 2nd ed. London: Lea & Febiger, 1990:461-2.
  • Woolf CJ, Chong MS. Preemptive analgesia-treating posto- perative pain by preventing the estabüshment of Central sensitization. Anesth Analg 1993;77:362-79.
  • Kehlet H, Dahi JB. The value of ‘multimodaT or ‘balanced analgesia' in postoperative pain treatment. Anesth Analg 1993;77:1048-56.
  • Fletcher D, Negre I, Barbin C, et al. Postoperative analge­ sia with iv propacetamol and ketoprofen combination after disc surgery. Can J Anaesth 1997;44:479-85.
  • Etches RC, Warriner CB, Badner N, et at. Continuous intra- venous administration of ketorolac reduces pain and morp- hine consumption after total hip or knee arthropiasty. Anesth Analg 1995;81:1175-80.
  • Sıddık SM, Aouad MT, Jalbout MI, Rizk LB, Kamar GH, Baraka AS. Diclofenac and/or propacetamol for postoperati­ ve pain management after cesarean delivery in patients receiving patient controlled analgesia morphine. Reg Anesth Pain Med 2001;26:310-5.
  • Lanas A, Sopena F. Nonsteroidal anti-infiammatory drugs and lower gastrointestinal complications. Gastroenterol d in North Am 2009;38:333-52.
  • Delbos A, Boccard E. The morphine sparing effect of pro­ pacetamol in orthopedic postoperative pain. J Pain Symptom Manage 1995;10:279-86.
  • Hernandez-Palazon J, Tortosa JA, Martines-Lage JF, Perez-Flores D. tntravenous administration of propacetamol reduces morphine consumption after spinal fusion surgery. Anesth Analg 2001;92:1473-6.
  • Varrassi G, Marinangeli F, Agro F, e t al. A double-blinded evaluation of propacetamol versus ketorolac in combination with patient controlled analgesia morphine: Analgesic effi- cacy and tolerability after gynecologic surgery. Anesth Analg 1999;88:611-6.
  • Aubrun F, Kalfon F, Mottet P, et al. Adjunctive analgesia with intravenous propacetamol does not reduce morphine-rela- ted adverse effects. Br J Anaesth 2003;90:314-9.
  • Binhas M, Decailliot F, Rezaiguia-Deiciaux S, et al. Comparative effect of intraoperative propacetamol versus piacebo on morphine consumption after elective reduction mammoplasty under remifentail-based anesthesia: A rando- mized control trial. BMC Anesthesiol 2004;14;4-6.
  • Avellaneda C, Gomez A, Martos F, Rubio M, Sarmiento J, de la Cuesta FS. The effect of a single intravenous dose of metamizol 2 g, ketorolac 30 mg and propacetamol 1 g on haemodynamic parameters and postoperative pain after heart surgery. Eur J Anaesthesioi 2000; 17:85-90.

The Effect of Irıtravenous Paracetamol on Morphine Consumption Used for Post-Operative Pain After Modified Radical Mastectomy

Year 2009, Volume: 42 Issue: 3, 100 - 104, 01.12.2009

Abstract

Postoperatif ağrı tedavisinde parasetamoi, tek başına veya opioidlerle kombine edilerek kullanılmaktadır. Bu çalışmada, modifiye radikal mastektomi uygulanan hastalarda postoperatif analjezi amacıyla kullanılan intravenöz (IV) parasetamolün morfin tüketimi üzerine etkisi araştırıldı. Genel anestezi ile modifiye radikal mastektomi uygulanacak ASA l-lll 60 hasta çalışmaya alındı. Premedikasyon yapılmayan hastalar kapalı zarf çekme yöntemiyle randomize olarak iki gruba ayrıldı (Grup P; n= 30, Grup S; n= 30). Anestezi indüksiyonu 1-2 pg/kg fentanil, 0.15 mg/kg cisatrakuryum ve 2-2.5 mg/kg propofol, idame %1-2 sevofluran, %66 N20/02 ile sağlandı. Grup P'ye cerrahi bitiminden bir saat önce ve postoperatif 24 saat süreyle, altı saat arayla 1 g IV paraseta-mol 15 dakika in füzyon şeklinde uygulandı. Grup S'ye aynı zaman aralıklarında şalin in füzyonu yapıldı. Postoperatif her iki gruba da morfin ile hazırlanmış hasta kontrollü analjezi cihazı bağlandı. Morfin dozları 5 mg yükleme dozu, beş dakika kilit süresi ve 1 mg bolus olarak ayarlandı. Vizüel analog skala (VAS) >4 ise 5 mg IV morfin botus dozu yapıldı. VAS ağrı skorları, sedasyon, solunum sayısı, kalp hızı, kan basıncı, Sp02, total morfin tüketimi ve yan etkiler takip edildi. Demografik özellikler her iki grupta benzerdi. Grup P'de morfin tüketimi %40 daha az bulundu (p< 0.001). istenilen ve verilen bolus sayısı Grup S'de anlamlı olarak daha fazlaydı (p< 0.001). VAS skorları parasetamoi uygulanan grupta daha düşüktü (p< 0.008). Bulantı, kusma, idrar retansiyonu ve kaşıntı gibi yan etkiler Grup S'de daha fazla görülmekle birlikte istatistiksel olarak anlamlı değildi. Bu çalışmada, postoperatif ağrı tedavisinde kullanılan IV parasetamolün etkin bir analjezi sağlarken morfin tüketimi ve istatistiksel olarak anlamlı olmamakla beraber yan etki insidansını azalttığı gösterildi.

References

  • Eti Z Postoperatif ağrı tedavisi. Erdine S (editör). Ağrı. 3. Baskı. İstanbul: Nobei Matbaacılık, 2007:150-73.
  • Peduto VA, Ballabio M, Stefanini S. Efficacy of propaceta- mol in the treatment of postoperative pain. Morphine spa- ring effect in orthopedic surgery. Italian Colloborative Group on Propacetamol. Açta Anaesthesiol Scand 1998;42:293-8.
  • Holmer Petterson P, Owall A, Jakobsson J. Early bioavaila
  • bility of paracetamoi after oral or intravenous administration. Açta Anaesthesiol Scand 2004;48:867-70.
  • Bonica JJ. Postoperative pain. İn: Bonica JJ (ed). The management of Pain. 2nd ed. London: Lea & Febiger, 1990:461-2.
  • Woolf CJ, Chong MS. Preemptive analgesia-treating posto- perative pain by preventing the estabüshment of Central sensitization. Anesth Analg 1993;77:362-79.
  • Kehlet H, Dahi JB. The value of ‘multimodaT or ‘balanced analgesia' in postoperative pain treatment. Anesth Analg 1993;77:1048-56.
  • Fletcher D, Negre I, Barbin C, et al. Postoperative analge­ sia with iv propacetamol and ketoprofen combination after disc surgery. Can J Anaesth 1997;44:479-85.
  • Etches RC, Warriner CB, Badner N, et at. Continuous intra- venous administration of ketorolac reduces pain and morp- hine consumption after total hip or knee arthropiasty. Anesth Analg 1995;81:1175-80.
  • Sıddık SM, Aouad MT, Jalbout MI, Rizk LB, Kamar GH, Baraka AS. Diclofenac and/or propacetamol for postoperati­ ve pain management after cesarean delivery in patients receiving patient controlled analgesia morphine. Reg Anesth Pain Med 2001;26:310-5.
  • Lanas A, Sopena F. Nonsteroidal anti-infiammatory drugs and lower gastrointestinal complications. Gastroenterol d in North Am 2009;38:333-52.
  • Delbos A, Boccard E. The morphine sparing effect of pro­ pacetamol in orthopedic postoperative pain. J Pain Symptom Manage 1995;10:279-86.
  • Hernandez-Palazon J, Tortosa JA, Martines-Lage JF, Perez-Flores D. tntravenous administration of propacetamol reduces morphine consumption after spinal fusion surgery. Anesth Analg 2001;92:1473-6.
  • Varrassi G, Marinangeli F, Agro F, e t al. A double-blinded evaluation of propacetamol versus ketorolac in combination with patient controlled analgesia morphine: Analgesic effi- cacy and tolerability after gynecologic surgery. Anesth Analg 1999;88:611-6.
  • Aubrun F, Kalfon F, Mottet P, et al. Adjunctive analgesia with intravenous propacetamol does not reduce morphine-rela- ted adverse effects. Br J Anaesth 2003;90:314-9.
  • Binhas M, Decailliot F, Rezaiguia-Deiciaux S, et al. Comparative effect of intraoperative propacetamol versus piacebo on morphine consumption after elective reduction mammoplasty under remifentail-based anesthesia: A rando- mized control trial. BMC Anesthesiol 2004;14;4-6.
  • Avellaneda C, Gomez A, Martos F, Rubio M, Sarmiento J, de la Cuesta FS. The effect of a single intravenous dose of metamizol 2 g, ketorolac 30 mg and propacetamol 1 g on haemodynamic parameters and postoperative pain after heart surgery. Eur J Anaesthesioi 2000; 17:85-90.
There are 17 citations in total.

Details

Primary Language Turkish
Journal Section Articles
Authors

Cengizhan Emre This is me

Gonca Tuncel This is me

Menşure Kaya This is me

Özgür Canoler This is me

Mehmet Özgür Yıldırım This is me

Nihal Kadıoğulları This is me

Publication Date December 1, 2009
Published in Issue Year 2009 Volume: 42 Issue: 3

Cite

APA Emre, C. ., Tuncel, G. ., Kaya, M. ., Canoler, Ö. ., et al. (2009). The Effect of Irıtravenous Paracetamol on Morphine Consumption Used for Post-Operative Pain After Modified Radical Mastectomy. Acta Oncologica Turcica, 42(3), 100-104.
AMA Emre C, Tuncel G, Kaya M, Canoler Ö, Yıldırım MÖ, Kadıoğulları N. The Effect of Irıtravenous Paracetamol on Morphine Consumption Used for Post-Operative Pain After Modified Radical Mastectomy. Acta Oncologica Turcica. December 2009;42(3):100-104.
Chicago Emre, Cengizhan, Gonca Tuncel, Menşure Kaya, Özgür Canoler, Mehmet Özgür Yıldırım, and Nihal Kadıoğulları. “The Effect of Irıtravenous Paracetamol on Morphine Consumption Used for Post-Operative Pain After Modified Radical Mastectomy”. Acta Oncologica Turcica 42, no. 3 (December 2009): 100-104.
EndNote Emre C, Tuncel G, Kaya M, Canoler Ö, Yıldırım MÖ, Kadıoğulları N (December 1, 2009) The Effect of Irıtravenous Paracetamol on Morphine Consumption Used for Post-Operative Pain After Modified Radical Mastectomy. Acta Oncologica Turcica 42 3 100–104.
IEEE C. . Emre, G. . Tuncel, M. . Kaya, Ö. . Canoler, M. Ö. . Yıldırım, and N. . Kadıoğulları, “The Effect of Irıtravenous Paracetamol on Morphine Consumption Used for Post-Operative Pain After Modified Radical Mastectomy”, Acta Oncologica Turcica, vol. 42, no. 3, pp. 100–104, 2009.
ISNAD Emre, Cengizhan et al. “The Effect of Irıtravenous Paracetamol on Morphine Consumption Used for Post-Operative Pain After Modified Radical Mastectomy”. Acta Oncologica Turcica 42/3 (December 2009), 100-104.
JAMA Emre C, Tuncel G, Kaya M, Canoler Ö, Yıldırım MÖ, Kadıoğulları N. The Effect of Irıtravenous Paracetamol on Morphine Consumption Used for Post-Operative Pain After Modified Radical Mastectomy. Acta Oncologica Turcica. 2009;42:100–104.
MLA Emre, Cengizhan et al. “The Effect of Irıtravenous Paracetamol on Morphine Consumption Used for Post-Operative Pain After Modified Radical Mastectomy”. Acta Oncologica Turcica, vol. 42, no. 3, 2009, pp. 100-4.
Vancouver Emre C, Tuncel G, Kaya M, Canoler Ö, Yıldırım MÖ, Kadıoğulları N. The Effect of Irıtravenous Paracetamol on Morphine Consumption Used for Post-Operative Pain After Modified Radical Mastectomy. Acta Oncologica Turcica. 2009;42(3):100-4.