Yüksek Doz Tedavi Sonrasında Nükseden Testis Kanserli Bir Hastada Gemsitabin ve Paklitaksel Kurtarma Tedavisi

Year 2009, Volume: 42 Issue: 3, 132 - 134, 01.12.2009

Ülkü Yalçintaş Arslan Ercan Arpacı Saadet Tokluoğlu Ayşe Durnalı Nazan Gökbayrak Necati Alkış

Abstract

The majority of patients vvith metastatic non-seminomatous germ celi tumors can be cured by cisplatin based combination chemotherapy. Hovvever, patients vvhose condition is cisptatin-refractory or who have recurrence after high dose chemotherapy have vvorse prognosis. We presented here, a 25 years old male patients was diagnosed metastatic embriyonaI testicular carcinoma. The patients received bleomycin, etoposide, cisplatin (BEP) regimen as first line chemotherapy. He experienced early brain relaps and as second line chemotherapy vinblastine, ifosfamide, cisplatin (VeİP) therapy was used. He undervvent high dose chemotherapy vvith peripheric stem celi rescue. For the patient experienced a second recurrence, gemcitabine and pacli-taxel was administered as salvage chemotherapy. He is alive and is free from disease at 30 months.

Keywords

Testicular cancer, gemcitabine, paclitaxel, salvage treatment.

Gemcitabine PlusPaclitaxel STherapy in a Patient vvith Relapsed Testicular Cancer After High Dose Therapy

Abstract

Metastatik testis tümörlerinin oldukça büyük bir kısmı platin temelli tedavi ile iyileşir. Sisplatin dirençli yada yüksek doz tedavi uygulamaları sonrası nükseden olguların prognozu oldukça kötüdür. Bu olgu sunumunda 25 yaşında metastatik testis embriyona! karsinoma tanısı alan bir erkek hasta bildirilmiştir. Birinci basamak tedavi olarak bleomisin, etoposid, sisplatin (BEP) kemoterapi rejimi uygulanan hasta beyin metastazı ile nüksetti ve ikinci sıra vinblastin, ifosfamid, sisplatin (VeİP) tedavisi sonrası yüksek doz kemoterapi ve periferik kök hücre nakli uygulandı. Sonrasında nüks hastalık gelişen olguya kurtarma tedavisi olarak gemsitabin, paklitaksel kombinasyonu verildi. Olgu 30. ayda halen remisyonda izlenmektedir.

Keywords

Testis kanseri, gemsitabin, paklitaksel, kurtarma tedavisi.

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