Treatment Faiiure of Disseminated Trichosporon asahii infection vvith Voriconazole in a Patient vvith Acute Myeloid Leukemia

Fatih  Kurnaz; Leylagül  Kaynar; Suat  Doğan; Bülent  Eser; Gökhan  Metan

Treatment Faiiure of Disseminated Trichosporon asahii infection vvith Voriconazole in a Patient vvith Acute Myeloid Leukemia

Year 2010, Volume: 43 Issue: 1, 32 - 35, 01.04.2010

Fatih Kurnaz Leylagül Kaynar Suat Doğan Bülent Eser Gökhan Metan

Abstract

Trichosporon asahii derin ve yaygın trikosporonozis infeksiyonun en önemli etkenlerinden biridir. Uzun süren nötropenide prognozu oldukça kötüdür. Bu olgu sunumunda 20 yaşında yaygın Trichosporon asahii infeksiyonu gelişen akut miyeloid lösemili bir hastada antifungal tedavi başarısızlığı bildirildi. Antifungal duyarlılığına göre vorikonazoi ve "vorikonazoi + lipozomal amfoterisin-B kombinasyon" tedavisi verilmesine rağmen hastada herhangi bir klinik düzelme izlenmedi. Antifungal tedavi altında hastada karaciğer ve dalakta lezyon tespit edildi. Kemik iliği değerlendirmesinde akut löseminin remisyonda olduğu görüldü. Bu olgu sunumunda yaygın Trichosporon asahii infeksiyonunda literatürün aksine vorikonazoi tedavisinin etkin olmayabileceği ve en iyi tedavi yönteminin halen net olmadığı sonucuna varıldı.

Keywords

Trichosporon asahii, vorikonazoi, akut lösemi.

Yaygın Trichosporon asahii İnfeksiyonu Olan Akut Miyeloid Lösemili Bir Hastada Vorikonazol Tedavi Başarısızlığı

Year 2010, Volume: 43 Issue: 1, 32 - 35, 01.04.2010

Fatih Kurnaz Leylagül Kaynar Suat Doğan Bülent Eser Gökhan Metan

Abstract

Infection vvith Trichosporon asahii is a majör cause of deep-seated and disseminated trichosporonosis, that have a very poor prognosis in patients vvith persistent neutropenia. We report a 20-year-oid girl vvith acute myeloid leukemia who developed disseminated Trichosporon asahii infection. Antifungal susceptibility vvas determined. No clinical improvement vvas seen despite the use of voriconazole and voriconazole plus liposomal amphotericin-B combination treatment, contrarity multiple hepatic and splenic lesions vvere seen under antifungal therapy. Bone marrow aspiration shovved that acute myeloid leukemia vvas on remission. İn this case it vvas concluded that voriconazole treatment may not be useful in the treatment of disseminated Trichosporon asahii infection and best treatment modaiity of Trichosporon asahii stili remains controversial.

Keywords

Trichosporon asahii, voriconazole, acute leukemia.

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Details

Primary Language	Turkish
Journal Section	Articles
Authors	Fatih Kurnaz This is me Leylagül Kaynar This is me Suat Doğan This is me Bülent Eser This is me Gökhan Metan This is me
Publication Date	April 1, 2010
Published in Issue	Year 2010 Volume: 43 Issue: 1

Cite

APA	Kurnaz, F. ., Kaynar, L. ., Doğan, S. ., Eser, B. ., et al. (2010). Treatment Faiiure of Disseminated Trichosporon asahii infection vvith Voriconazole in a Patient vvith Acute Myeloid Leukemia. Acta Oncologica Turcica, 43(1), 32-35.
AMA	Kurnaz F, Kaynar L, Doğan S, Eser B, Metan G. Treatment Faiiure of Disseminated Trichosporon asahii infection vvith Voriconazole in a Patient vvith Acute Myeloid Leukemia. Acta Oncologica Turcica. April 2010;43(1):32-35.
Chicago	Kurnaz, Fatih, Leylagül Kaynar, Suat Doğan, Bülent Eser, and Gökhan Metan. “Treatment Faiiure of Disseminated Trichosporon Asahii Infection Vvith Voriconazole in a Patient Vvith Acute Myeloid Leukemia”. Acta Oncologica Turcica 43, no. 1 (April 2010): 32-35.
EndNote	Kurnaz F, Kaynar L, Doğan S, Eser B, Metan G (April 1, 2010) Treatment Faiiure of Disseminated Trichosporon asahii infection vvith Voriconazole in a Patient vvith Acute Myeloid Leukemia. Acta Oncologica Turcica 43 1 32–35.
IEEE	F. . Kurnaz, L. . Kaynar, S. . Doğan, B. . Eser, and G. . Metan, “Treatment Faiiure of Disseminated Trichosporon asahii infection vvith Voriconazole in a Patient vvith Acute Myeloid Leukemia”, Acta Oncologica Turcica, vol. 43, no. 1, pp. 32–35, 2010.
ISNAD	Kurnaz, Fatih et al. “Treatment Faiiure of Disseminated Trichosporon Asahii Infection Vvith Voriconazole in a Patient Vvith Acute Myeloid Leukemia”. Acta Oncologica Turcica 43/1 (April 2010), 32-35.
JAMA	Kurnaz F, Kaynar L, Doğan S, Eser B, Metan G. Treatment Faiiure of Disseminated Trichosporon asahii infection vvith Voriconazole in a Patient vvith Acute Myeloid Leukemia. Acta Oncologica Turcica. 2010;43:32–35.
MLA	Kurnaz, Fatih et al. “Treatment Faiiure of Disseminated Trichosporon Asahii Infection Vvith Voriconazole in a Patient Vvith Acute Myeloid Leukemia”. Acta Oncologica Turcica, vol. 43, no. 1, 2010, pp. 32-35.
Vancouver	Kurnaz F, Kaynar L, Doğan S, Eser B, Metan G. Treatment Faiiure of Disseminated Trichosporon asahii infection vvith Voriconazole in a Patient vvith Acute Myeloid Leukemia. Acta Oncologica Turcica. 2010;43(1):32-5.