Toxic Effects of Bisphenol S on the Gonad and Visceral Organs of Goldfish (Carassius auratus)

Yıl 2021, Cilt: 17 Sayı: 1, 129 - 135, 01.03.2021

İkbal Demet Nane , Öznur Özil , Mert Minaz , Mevlüt Nazıroğlu , Öznur Diler , Özlem Özmen

https://doi.org/10.22392/actaquatr.767061

Cited By: 4

Öz

Bisphenol-A (BPA) is an environmental contaminant used in the manufacturing of polycarbonate plastics and epoxy resins. Whereas bisphenol S (BPS) is a bisphenol analogue which is recently used to replace BPA products. We demonstrated the effects of BPS on liver, kidney, gonad, and gills in goldfish (Carassius auratus) by a histopathological examination. Fishes treated with different concentrations (0, 100 and 500 μg/L) of BPS were tested for a duration of 21-days. In gills, BPS caused hyperemia, edema, epithelial desquamation and necrosis. Kidney lesions included necrosis and melanomacrophage infiltrations. BPS stress caused hyperemia and inflammatory cell infiltrations in livers. The present study revealed that BPS causes degenerative changes in various visceral organs of Carassius auratus and severity of histopathological changes were dose related.

Anahtar Kelimeler

Endocrine disruptor, microplastic, histopathology, xenoestrogen

Japon Balığı (Carassius auratus) Gonad ve Viseral Organları Üzerine Bisfenol S’nin Toksik Etkileri

Öz

Bisfenol A (BPA), polikarbonat plastiklerin ve epoksi reçinelerinin üretiminde kullanılan çevresel bir kirleticidir. Bununla birlikte bisfenol S (BPS), son zamanlarda BPA ürünlerine alternatif olarak kullanılmaya başlanan bir bisfenol analoğudur. Bu çalışmada farklı BPS konsantrasyonlarına (0, 100 ve 500 μg/L) 21 gün maruz bırakılan japon balıklarının (Carassius auratus) karaciğer, böbrek, gonad ve solungaç dokularındaki bir dizi etki histopatolojik olarak belirlenmiştir. Solungaçlarda BPS’nin hiperemi, ödem, epitel hücrelerinde deskuamasyon ve nekroza neden olduğu dikkat çekmiştir. Böbreklerde nekroz ve melanomakrofaj infiltrasyonları sıklıkla gözlenmiştir. Karaciğerde BPS’nin hiperemi ve inflamatuar hücre infiltrasyonlarına neden olduğu saptanmıştır. Bu çalışma, BPS'nin Carassius auratus'un çeşitli viseral organlarında dejeneratif değişikliklere neden olduğu ve histopatolojik değişikliklerin şiddetinin doza bağlı olduğunu ortaya koymuştur

Anahtar Kelimeler

Endokrin bozucu, mikroplastik, histopatoloji, ksenoöstrojen

Kaynakça

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