Review
BibTex RIS Cite

The Effect of the Use of Some Antioxidants as Irrigation Solutions in Endodontics on Bond Strength

Year 2025, Volume: 11 Issue: 3, 295 - 302, 31.12.2025

Abstract

References

  • Möller ÅJ, Fabricius L, Dahlen G, Öhmen AE, Heyden GU. Influence on periapical tissues of indigenous oral bacteria and necrotic pulp tissue in monkeys. Eur J Oral Sci. 1981;89(6):475-84.
  • Hahn CL, Liewehr FR. Innate immune responses of the dental pulp to caries. J Endod. 2007;33(6):643-51.
  • Tibúrcio-Machado CS, Michelon C, Zanatta FB, Gomes MS, Marin JA, Bier CA. The global prevalence of apical periodontitis: a systematic review and meta-analysis. Int Endod J. 2021;54(5):712-35.
  • Sundqvist G. Ecology of the root canal flora. J Endod. 1992;18(9):427-30.
  • Orstavik D, editor. Essential endodontology: prevention and treatment of apical periodontitis. Hoboken: John Wiley & Sons; 2020.
  • Ricucci D, Siqueira JF Jr, Bate AL, Ford TR. Histologic investigation of root canal–treated teeth with apical periodontitis: a retrospective study from twenty-four patients. J Endod. 2009;35(4):493-502.
  • Siqueira JF Jr, Rôças IN, Santos SR, Lima KC, Magalhães FA, de Uzeda M. Efficacy of instrumentation techniques and irrigation regimens in reducing the bacterial population within root canals. J Endod. 2002 ;28(3):181-4.
  • Becker TD, Woollard GW. Endodontic irrigation. Gen Dent. 2001;49(3):272-6.
  • Siqueira JF Jr, Machado AG, Silveira RM, Lopes HP, de Uzeda M. Evaluation of the effectiveness of sodium hypochlorite used with three irrigation methods in the elimination of Enterococcus faecalis from the root canal: an in vitro study. Int Endod J. 1997;30(4):279-82.
  • Williamson AE, Cardon JW, Drake DR. Antimicrobial susceptibility of monoculture biofilms of a clinical isolate of Enterococcus faecalis. J Endod. 2009;35(1):95-7.
  • Josic U, Mazzitelli C, Maravic T, Fidler A, Breschi L, Mazzoni A. Biofilm in endodontics: in vitro cultivation possibilities, sonic-, ultrasonic-, and laser-assisted removal techniques and evaluation of the cleaning efficacy. Polymers. 2022;14(7):1334.
  • Ghisi AC, Kopper PMP, Baldasso FE, et al. Effect of superoxidized water and sodium hypochlorite, associated or not with EDTA, on organic and inorganic components of bovine root dentin. J Endod. 2015;41(6):925-30.
  • Bertassoni LE, Orgel JP, Antipova O, Swain MV. The dentin organic matrix – limitations of restorative dentistry hidden on the nanometer scale. Acta Biomater. 2012;8(7):2419-33.
  • Oyarzún A, Rathkamp H, Dreyer E. Immunohistochemical and ultrastructural evaluation of the effects of phosphoric acid etching on dentin proteoglycans. Eur J Oral Sci. 2000;108(6):546-54.
  • Zhang YR, Du W, Zhou XD, Yu HY. Review of research on the mechanical properties of the human tooth. Int J Oral Sci. 2014;6(2):61-9.
  • Cecchin D, Farina AP, Bedran-Russo AK. The effects of endodontic substances and naturally reducing agents on the bond strength of epoxy resin-based sealer to root dentin. J Conserv Dent. 2017;20(5):302-6.
  • Corrêa AC, Cecchin D, de Almeida JF, Gomes BPFA, Zaia AA, Ferraz CC. Sodium thiosulfate for recovery of bond strength to dentin treated with sodium hypochlorite. J Endod. 2016;42(2):284-8.
  • Sharafeddin F, Farshad F. The effect of aloe vera, pomegranate peel, grape seed extract, green tea, and sodium ascorbate as antioxidants on the shear bond strength of composite resin to homebleached enamel. J Dent. 2015;16(4):296.
  • Rose RC, Bode AM. Biology of free radical scavengers: an evaluation of ascorbate. FASEB J. 1993 ;7(12):1135-42.
  • Carnelio S, Khan SA, Rodrigues G. Definite, probable or dubious: antioxidants trilogy in clinical dentistry. Br Dent J. 2008;204(1):29-32.
  • Sen S, Chakraborty R. The role of antioxidants in human health. In: Oxidative stress: diagnostics, prevention, and therapy. Washington (DC): American Chemical Society; 2011. p. 1-37.
  • Sen S, Chakraborty R, Sridhar C, Reddy YS, De B. Free radicals, antioxidants, diseases and phytomedicines: current status and future prospect. Int J Pharm Sci Rev Res. 2010;3(1):91- 100.
  • Shetti A, Keluskar V, Aggarwal A. Antioxidants: enhancing oral and general health. J Indian Acad Oral Med Radiol. 2009 J;21(1):1-6.
  • Finkel T, Holbrook NJ. Oxidants, oxidative stress and the biology of ageing. Nature. 2000;408(6809):239-47.
  • Tang B, Yuan H, Cheng L, Zhou X, Huang X, Li J. Effects of gallic acid on the morphology and growth of hydroxyapatite crystals. Arch Oral Biol. 2015; 60(1):167-73.
  • Gascón R, Forner L, Llena C. The effect of antioxidants on dentin bond strength after application of common endodontic irrigants: a systematic review. Materials. 2023;16(6):2260.
  • Liu Z, Feng X, Wang X, Yang S, Mao J, Gong S. Quercetin as an auxiliary endodontic irrigant for root canal treatment: anti-biofilm and dentin collagen-stabilizing effects in vitro. Materials. 202;14(5):1178.
  • Fine AM. Oligomeric proanthocyanidin complexes: history, structure, and phytopharmaceutical applications. Altern Med Rev. 2000;5(2):144-51.
  • Hu M, McClements DJ, Decker EA. Antioxidant activity of a proanthocyanidin-rich extract from grape seed in whey protein isolate–stabilized algae oil-in-water emulsions. J Agric Food Chem. 2004;52(16):5272-6.
  • Kennedy JA, Taylor AW. Analysis of proanthocyanidins by high-performance gel permeation chromatography. J Chromatogr A. 2003;995(1-2):99-107.
  • Naczk M, Shahidi F. Extraction and analysis of phenolics in food. J Chromatogr A. 2004;1054(1- 2):95-111.
  • Masquelier J, Dumon MC, Dumas J. Stabilization of collagen by procyanidolic oligomers. Acta Ther. 1981;7:101-5.
  • Castellan CS, Pereira PN, Viana G, Chen SN, Pauli GF, Bedran-Russo AK. Solubility study of phytochemical cross-linking agents on dentin stiffness. J Dent. 2010;38(5):431-6.
  • Bedran-Russo AK, Pereira PN, Duarte WR, Drummond JL, Yamauchi M. Application of crosslinkers to dentin collagen enhances the ultimate tensile strength. J Biomed Mater Res B Appl Biomater. 2007;80(1):268-72.
  • Soeno K, Taira Y, Jimbo R, Sawase T. Surface treatment with ascorbic acid and ferric chloride improves the micro-tensile bond strength of 4-META/MMA-TBB resin to dentin. J Dent. 2008;36(11):940-4.
  • Komabayashi T, Ahn C, Zhang S, Zhu Q, Spångberg LS. Root dentin body moisture changes caused by ascorbic acid. J Dent. 2009;37(6):475-9.
  • Vongphan N, Senawongse P, Somsiri W, Harnirattisai C. Effects of sodium ascorbate on microtensile bond strength of total-etching adhesive system to NaOCl-treated dentine. J Dent. 2005;33(8):689-95.
  • Moura AS, Pereira RD, Rached-Junior FJ, et al. Influence of root dentin treatment on the pushout bond strength of fibre-reinforced posts. Braz Oral Res. 2017 ;31:e29.
  • Morris MD, Lee KW, Agee KA, Bouillaguet S, Pashley DH. Effects of sodium hypochlorite and RC-Prep on bond strengths of resin cement to endodontic surfaces. J Endod. 2001;27(12):753- 7.
  • Khoroushi M, Mazaheri H, Tarighi P, Samimi P, Khalighinejad N. Effect of antioxidants on pushout bond strength of hydrogen peroxide–treated glass fiber posts bonded with two types of resin cement. Restor Dent Endod. 2014;39(4):303-9.
  • Park JY, Kwon TY, Kim YK. Effective application duration of sodium ascorbate antioxidant in reducing microleakage of bonded composite restoration in intracoronally bleached teeth. Restor Dent Endod. 2013 ;38(1):43-7.
  • Stevens CD. Immediate shear bond strength of resin cements to sodium hypochlorite–treated dentin. J Endod. 2014;40(9):1459-62.
  • Havsteen BJ. Flavonoids: a class of natural products of high pharmacological potency. Biochem Pharmacol. 1983;32(7):1141-8.
  • Sasaki RT, Flório FM, Basting RT. Effect of 10% sodium ascorbate and 10% α-tocopherol in different formulations on the shear bond strength of enamel and dentin submitted to a home-use bleaching treatment. Oper Dent. 2009;34(6):746- 52.
  • Thapa A, Vivekananda PA, Thomas MS. Evaluation and comparison of bond strength to 10% carbamide peroxide–bleached enamel following the application of 10% and 25% sodium ascorbate and alpha-tocopherol solutions: an in vitro study. J Conserv Dent Endod. 2013;16(2):111-5.
  • Sultan MS, Elkorashy ME. Influence of natural antioxidants on microshear bond strength to bleached enamel: chemical versus laser-assisted bleaching. Egypt Dent J. 2017;63(2):1783-91.
  • Gogia H, Taneja S, Kumar M, Soi S. Effect of different antioxidants on reversing compromised resin bond strength after enamel bleaching: an in vitro study. J Conserv Dent. 2018;21(1):100-4.
  • Theriault A, Chao JT, Wang QI, Gapor A, Adeli K. Tocotrienol: a review of its therapeutic potential. Clin Biochem. 1999;32(5):309-19.

Endodontide Yıkama Solüsyonu Olarak Bazı Antioksidanların Kullanımının Bağlanma Dayanımı Üzerine Etkisi

Year 2025, Volume: 11 Issue: 3, 295 - 302, 31.12.2025

Abstract

Mikroorganizmalar ve yan ürünleri pulpa ve periradiküler patolojide kritik rol oynar. Kanal tedavisinin temel amaçlarından biri kanal sisteminin dezenfekte edilmesidir. Bu amaçla mekanik temizlik yapılırken kimyasal irigasyon solüsyonları, çeşitli yıkama protokolleriyle kullanılmaktadır. Bu derlemede en yaygın kullanılan solüsyonlara ek olarak antioksidan kullanımı ele alınmıştır. Antioksidanların bilinen en önemli etkisi, serbest radikallerin zararlı etkilerini nötralize etmeleridir. Rutin olmasa da endodontide ve adeziv işlemlerde antioksidanların uygulanması yaygınlaşmaya başlamış ve bu ürünlerin etkin kullanımını belirlemek için çalışmalar yapılmaktadır. Bu derlemenin amacı antioksidanlar ve endodontideki potansiyel rolleri hakkında bilgi sunmaktadır.

References

  • Möller ÅJ, Fabricius L, Dahlen G, Öhmen AE, Heyden GU. Influence on periapical tissues of indigenous oral bacteria and necrotic pulp tissue in monkeys. Eur J Oral Sci. 1981;89(6):475-84.
  • Hahn CL, Liewehr FR. Innate immune responses of the dental pulp to caries. J Endod. 2007;33(6):643-51.
  • Tibúrcio-Machado CS, Michelon C, Zanatta FB, Gomes MS, Marin JA, Bier CA. The global prevalence of apical periodontitis: a systematic review and meta-analysis. Int Endod J. 2021;54(5):712-35.
  • Sundqvist G. Ecology of the root canal flora. J Endod. 1992;18(9):427-30.
  • Orstavik D, editor. Essential endodontology: prevention and treatment of apical periodontitis. Hoboken: John Wiley & Sons; 2020.
  • Ricucci D, Siqueira JF Jr, Bate AL, Ford TR. Histologic investigation of root canal–treated teeth with apical periodontitis: a retrospective study from twenty-four patients. J Endod. 2009;35(4):493-502.
  • Siqueira JF Jr, Rôças IN, Santos SR, Lima KC, Magalhães FA, de Uzeda M. Efficacy of instrumentation techniques and irrigation regimens in reducing the bacterial population within root canals. J Endod. 2002 ;28(3):181-4.
  • Becker TD, Woollard GW. Endodontic irrigation. Gen Dent. 2001;49(3):272-6.
  • Siqueira JF Jr, Machado AG, Silveira RM, Lopes HP, de Uzeda M. Evaluation of the effectiveness of sodium hypochlorite used with three irrigation methods in the elimination of Enterococcus faecalis from the root canal: an in vitro study. Int Endod J. 1997;30(4):279-82.
  • Williamson AE, Cardon JW, Drake DR. Antimicrobial susceptibility of monoculture biofilms of a clinical isolate of Enterococcus faecalis. J Endod. 2009;35(1):95-7.
  • Josic U, Mazzitelli C, Maravic T, Fidler A, Breschi L, Mazzoni A. Biofilm in endodontics: in vitro cultivation possibilities, sonic-, ultrasonic-, and laser-assisted removal techniques and evaluation of the cleaning efficacy. Polymers. 2022;14(7):1334.
  • Ghisi AC, Kopper PMP, Baldasso FE, et al. Effect of superoxidized water and sodium hypochlorite, associated or not with EDTA, on organic and inorganic components of bovine root dentin. J Endod. 2015;41(6):925-30.
  • Bertassoni LE, Orgel JP, Antipova O, Swain MV. The dentin organic matrix – limitations of restorative dentistry hidden on the nanometer scale. Acta Biomater. 2012;8(7):2419-33.
  • Oyarzún A, Rathkamp H, Dreyer E. Immunohistochemical and ultrastructural evaluation of the effects of phosphoric acid etching on dentin proteoglycans. Eur J Oral Sci. 2000;108(6):546-54.
  • Zhang YR, Du W, Zhou XD, Yu HY. Review of research on the mechanical properties of the human tooth. Int J Oral Sci. 2014;6(2):61-9.
  • Cecchin D, Farina AP, Bedran-Russo AK. The effects of endodontic substances and naturally reducing agents on the bond strength of epoxy resin-based sealer to root dentin. J Conserv Dent. 2017;20(5):302-6.
  • Corrêa AC, Cecchin D, de Almeida JF, Gomes BPFA, Zaia AA, Ferraz CC. Sodium thiosulfate for recovery of bond strength to dentin treated with sodium hypochlorite. J Endod. 2016;42(2):284-8.
  • Sharafeddin F, Farshad F. The effect of aloe vera, pomegranate peel, grape seed extract, green tea, and sodium ascorbate as antioxidants on the shear bond strength of composite resin to homebleached enamel. J Dent. 2015;16(4):296.
  • Rose RC, Bode AM. Biology of free radical scavengers: an evaluation of ascorbate. FASEB J. 1993 ;7(12):1135-42.
  • Carnelio S, Khan SA, Rodrigues G. Definite, probable or dubious: antioxidants trilogy in clinical dentistry. Br Dent J. 2008;204(1):29-32.
  • Sen S, Chakraborty R. The role of antioxidants in human health. In: Oxidative stress: diagnostics, prevention, and therapy. Washington (DC): American Chemical Society; 2011. p. 1-37.
  • Sen S, Chakraborty R, Sridhar C, Reddy YS, De B. Free radicals, antioxidants, diseases and phytomedicines: current status and future prospect. Int J Pharm Sci Rev Res. 2010;3(1):91- 100.
  • Shetti A, Keluskar V, Aggarwal A. Antioxidants: enhancing oral and general health. J Indian Acad Oral Med Radiol. 2009 J;21(1):1-6.
  • Finkel T, Holbrook NJ. Oxidants, oxidative stress and the biology of ageing. Nature. 2000;408(6809):239-47.
  • Tang B, Yuan H, Cheng L, Zhou X, Huang X, Li J. Effects of gallic acid on the morphology and growth of hydroxyapatite crystals. Arch Oral Biol. 2015; 60(1):167-73.
  • Gascón R, Forner L, Llena C. The effect of antioxidants on dentin bond strength after application of common endodontic irrigants: a systematic review. Materials. 2023;16(6):2260.
  • Liu Z, Feng X, Wang X, Yang S, Mao J, Gong S. Quercetin as an auxiliary endodontic irrigant for root canal treatment: anti-biofilm and dentin collagen-stabilizing effects in vitro. Materials. 202;14(5):1178.
  • Fine AM. Oligomeric proanthocyanidin complexes: history, structure, and phytopharmaceutical applications. Altern Med Rev. 2000;5(2):144-51.
  • Hu M, McClements DJ, Decker EA. Antioxidant activity of a proanthocyanidin-rich extract from grape seed in whey protein isolate–stabilized algae oil-in-water emulsions. J Agric Food Chem. 2004;52(16):5272-6.
  • Kennedy JA, Taylor AW. Analysis of proanthocyanidins by high-performance gel permeation chromatography. J Chromatogr A. 2003;995(1-2):99-107.
  • Naczk M, Shahidi F. Extraction and analysis of phenolics in food. J Chromatogr A. 2004;1054(1- 2):95-111.
  • Masquelier J, Dumon MC, Dumas J. Stabilization of collagen by procyanidolic oligomers. Acta Ther. 1981;7:101-5.
  • Castellan CS, Pereira PN, Viana G, Chen SN, Pauli GF, Bedran-Russo AK. Solubility study of phytochemical cross-linking agents on dentin stiffness. J Dent. 2010;38(5):431-6.
  • Bedran-Russo AK, Pereira PN, Duarte WR, Drummond JL, Yamauchi M. Application of crosslinkers to dentin collagen enhances the ultimate tensile strength. J Biomed Mater Res B Appl Biomater. 2007;80(1):268-72.
  • Soeno K, Taira Y, Jimbo R, Sawase T. Surface treatment with ascorbic acid and ferric chloride improves the micro-tensile bond strength of 4-META/MMA-TBB resin to dentin. J Dent. 2008;36(11):940-4.
  • Komabayashi T, Ahn C, Zhang S, Zhu Q, Spångberg LS. Root dentin body moisture changes caused by ascorbic acid. J Dent. 2009;37(6):475-9.
  • Vongphan N, Senawongse P, Somsiri W, Harnirattisai C. Effects of sodium ascorbate on microtensile bond strength of total-etching adhesive system to NaOCl-treated dentine. J Dent. 2005;33(8):689-95.
  • Moura AS, Pereira RD, Rached-Junior FJ, et al. Influence of root dentin treatment on the pushout bond strength of fibre-reinforced posts. Braz Oral Res. 2017 ;31:e29.
  • Morris MD, Lee KW, Agee KA, Bouillaguet S, Pashley DH. Effects of sodium hypochlorite and RC-Prep on bond strengths of resin cement to endodontic surfaces. J Endod. 2001;27(12):753- 7.
  • Khoroushi M, Mazaheri H, Tarighi P, Samimi P, Khalighinejad N. Effect of antioxidants on pushout bond strength of hydrogen peroxide–treated glass fiber posts bonded with two types of resin cement. Restor Dent Endod. 2014;39(4):303-9.
  • Park JY, Kwon TY, Kim YK. Effective application duration of sodium ascorbate antioxidant in reducing microleakage of bonded composite restoration in intracoronally bleached teeth. Restor Dent Endod. 2013 ;38(1):43-7.
  • Stevens CD. Immediate shear bond strength of resin cements to sodium hypochlorite–treated dentin. J Endod. 2014;40(9):1459-62.
  • Havsteen BJ. Flavonoids: a class of natural products of high pharmacological potency. Biochem Pharmacol. 1983;32(7):1141-8.
  • Sasaki RT, Flório FM, Basting RT. Effect of 10% sodium ascorbate and 10% α-tocopherol in different formulations on the shear bond strength of enamel and dentin submitted to a home-use bleaching treatment. Oper Dent. 2009;34(6):746- 52.
  • Thapa A, Vivekananda PA, Thomas MS. Evaluation and comparison of bond strength to 10% carbamide peroxide–bleached enamel following the application of 10% and 25% sodium ascorbate and alpha-tocopherol solutions: an in vitro study. J Conserv Dent Endod. 2013;16(2):111-5.
  • Sultan MS, Elkorashy ME. Influence of natural antioxidants on microshear bond strength to bleached enamel: chemical versus laser-assisted bleaching. Egypt Dent J. 2017;63(2):1783-91.
  • Gogia H, Taneja S, Kumar M, Soi S. Effect of different antioxidants on reversing compromised resin bond strength after enamel bleaching: an in vitro study. J Conserv Dent. 2018;21(1):100-4.
  • Theriault A, Chao JT, Wang QI, Gapor A, Adeli K. Tocotrienol: a review of its therapeutic potential. Clin Biochem. 1999;32(5):309-19.
There are 48 citations in total.

Details

Primary Language Turkish
Subjects Endodontics
Journal Section Review
Authors

Bilge Erdoğan 0000-0002-6030-3092

Ayça Yilmaz 0000-0002-9254-7710

Submission Date July 11, 2024
Acceptance Date August 26, 2024
Publication Date December 31, 2025
Published in Issue Year 2025 Volume: 11 Issue: 3

Cite

Vancouver Erdoğan B, Yilmaz A. Endodontide Yıkama Solüsyonu Olarak Bazı Antioksidanların Kullanımının Bağlanma Dayanımı Üzerine Etkisi. Aydin Dental Journal. 2025;11(3):295-302.

All site content, except where otherwise noted, is licensed under a Creative Common Attribution Licence. (CC-BY-NC 4.0)