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IS THE HYALURONIC ACID BENEFICAL FOR THE BONE HEALING IN DEFECTS OF CRITICAL SIZE IN ANGULUS MANDIBLE AREA?: AN EXPERIMENTAL STUDY

Year 2018, Volume: 4 Issue: 2, 1 - 8, 08.10.2018

Abstract

This study was aimed to evaluate the effect of hyaluronic acid on bone healing in an angulus mandible defect of a rabbit. Twenty-four New Zealand white male rabbits were used in this study. Bilateral 9x5 mm defects were made on the left and right angulus mandible of each rabbit. The left defect was filled with hyaluronic acid gel (experimental one), while the right defect was left for normal healing (control one). The rabbits were randomly divided and sacrificed during the 1st ,2nd ,3rd and 4th weeks postoperatively. The defect sites were evaluated by histologic analyses for bone healing at all healing interval. According to the histopathological examination results, there was statistically significant difference in the amount of new bone formation between hyaluronic acid and control groups (P < 0.05). On the 21st and 28th days, the amount of new bone formation was higher in hyaluronic acid groups. The inflammation scores were statistically lower in the hyaluronic acid group than the control group on the 28th day. Local injections of hyaluronic acid in mandibular critical size bone defect may improve new bone formation. Hyaluronic acid could be taken as a graft material for bone defects.

References

  • [1] Fillingham, Y. and J. Jacobs, Bone grafts and their substitutes. Bone Joint J, 2016. 98 (1 Supple A): p. 6-9. [2] Kinoshita, Y. and H. Maeda, Recent developments of functional scaffolds for craniomaxillofacial bone tissue engineering applications. The Scientific World Journal, 2013. [3] David‐Raoudi, M., et al., Differential effects of hyaluronan and its fragments on fibroblasts: relation to wound healing. Wound Repair and Regeneration, 2008. 16 (2): p. 274-287. [4] Frenkel, J.S., The role of hyaluronan in wound healing. International wound journal, 2014. 11 (2): p. 159-163. [5] Aya, K.L. and R. Stern, Hyaluronan in wound healing: rediscovering a major player. Wound repair and regeneration, 2014. 22 (5):p. 579-593. [6] Monslow, J., et al., Wounding-induced synthesis of hyaluronic acid in organotypic epidermal cultures requires the release of heparin-binding egf and activation of the EGFR. Journal of Investigative Dermatology, 2009. 129 (8): p. 2046-2058. [7] Hirshberg, A., et al., The influence of inflammation on the polarization colors of collagen fibers in the wall of odontogenic keratocyst. Oral oncology, 2007. 43 (3):p. 278-282. [8] Hollinger, J.O. and J.C. Kleinschmidt, The critical size defect as an experimental model to test bone repair materials. Journal of Craniofacial Surgery, 1990. 1 (1): p. 60-68. [9] Thomaidis, V., et al., Comparative study of 5 different membranes for guided bone regeneration of rabbit mandibular defects beyond critical size. Medical Science Monitor, 2008. 14 (4): p. BR67-BR73. [10] Dechert, T.A., et al., Hyaluronan in human acute and chronic dermal wounds. Wound Repair and Regeneration, 2006. 14 (3): p. 252-258. [11] Aguado, E., et al., β-TCP granules mixed with reticulated hyaluronic acid induce an increase in bone apposition. Biomedical Materials, 2013. 9 (1): p. 015001. [12] Sadikoglu, T., et al., Effect of hyaluronic acid on bone formation in the expanded interpremaxillary suture in rats. Orthodontics & craniofacial research, 2016. 19 (3): p. 154-161.
Year 2018, Volume: 4 Issue: 2, 1 - 8, 08.10.2018

Abstract

References

  • [1] Fillingham, Y. and J. Jacobs, Bone grafts and their substitutes. Bone Joint J, 2016. 98 (1 Supple A): p. 6-9. [2] Kinoshita, Y. and H. Maeda, Recent developments of functional scaffolds for craniomaxillofacial bone tissue engineering applications. The Scientific World Journal, 2013. [3] David‐Raoudi, M., et al., Differential effects of hyaluronan and its fragments on fibroblasts: relation to wound healing. Wound Repair and Regeneration, 2008. 16 (2): p. 274-287. [4] Frenkel, J.S., The role of hyaluronan in wound healing. International wound journal, 2014. 11 (2): p. 159-163. [5] Aya, K.L. and R. Stern, Hyaluronan in wound healing: rediscovering a major player. Wound repair and regeneration, 2014. 22 (5):p. 579-593. [6] Monslow, J., et al., Wounding-induced synthesis of hyaluronic acid in organotypic epidermal cultures requires the release of heparin-binding egf and activation of the EGFR. Journal of Investigative Dermatology, 2009. 129 (8): p. 2046-2058. [7] Hirshberg, A., et al., The influence of inflammation on the polarization colors of collagen fibers in the wall of odontogenic keratocyst. Oral oncology, 2007. 43 (3):p. 278-282. [8] Hollinger, J.O. and J.C. Kleinschmidt, The critical size defect as an experimental model to test bone repair materials. Journal of Craniofacial Surgery, 1990. 1 (1): p. 60-68. [9] Thomaidis, V., et al., Comparative study of 5 different membranes for guided bone regeneration of rabbit mandibular defects beyond critical size. Medical Science Monitor, 2008. 14 (4): p. BR67-BR73. [10] Dechert, T.A., et al., Hyaluronan in human acute and chronic dermal wounds. Wound Repair and Regeneration, 2006. 14 (3): p. 252-258. [11] Aguado, E., et al., β-TCP granules mixed with reticulated hyaluronic acid induce an increase in bone apposition. Biomedical Materials, 2013. 9 (1): p. 015001. [12] Sadikoglu, T., et al., Effect of hyaluronic acid on bone formation in the expanded interpremaxillary suture in rats. Orthodontics & craniofacial research, 2016. 19 (3): p. 154-161.
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Details

Primary Language English
Journal Section Research Article
Authors

Aykut Kahveci This is me

Mustafa Öztürk

Sibel Elif Gültekin This is me

Publication Date October 8, 2018
Submission Date August 8, 2018
Published in Issue Year 2018 Volume: 4 Issue: 2

Cite

Vancouver Kahveci A, Öztürk M, Gültekin SE. IS THE HYALURONIC ACID BENEFICAL FOR THE BONE HEALING IN DEFECTS OF CRITICAL SIZE IN ANGULUS MANDIBLE AREA?: AN EXPERIMENTAL STUDY. Aydin Dental Journal. 2018;4(2):1-8.

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