IS THE HYALURONIC ACID BENEFICAL FOR THE BONE HEALING IN DEFECTS OF CRITICAL SIZE IN ANGULUS MANDIBLE AREA?: AN EXPERIMENTAL STUDY

Year 2018, Volume: 4 Issue: 2, 1 - 8, 08.10.2018

Aykut Kahveci Mustafa Öztürk , Sibel Elif Gültekin

Abstract

This study was aimed to evaluate the effect of hyaluronic acid on bone healing in an angulus mandible defect of a rabbit. Twenty-four New Zealand white male rabbits were used in this study. Bilateral 9x5 mm defects were made on the left and right angulus mandible of each rabbit. The left defect was filled with hyaluronic acid gel (experimental one), while the right defect was left for normal healing (control one). The rabbits were randomly divided and sacrificed during the 1st ,2nd ,3rd and 4th weeks postoperatively. The defect sites were evaluated by histologic analyses for bone healing at all healing interval. According to the histopathological examination results, there was statistically significant difference in the amount of new bone formation between hyaluronic acid and control groups (P < 0.05). On the 21st and 28th days, the amount of new bone formation was higher in hyaluronic acid groups. The inflammation scores were statistically lower in the hyaluronic acid group than the control group on the 28th day. Local injections of hyaluronic acid in mandibular critical size bone defect may improve new bone formation. Hyaluronic acid could be taken as a graft material for bone defects.

Keywords

Bone healing, hyaluronic acid, rabbits

References

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