THE USE OF L-PRF TO PREVENT BISPHOSPHONATE OSTEONECROSIS IN ODONTOMA SURGERY: CASE REPORT
Year 2023,
Volume: 9 Issue: 2, 101 - 105, 31.08.2023
Melike Baygın Durak
,
Banu Gürkan Köseoğlu
Abstract
Medication related osteonecrosis of the jaw (MRONJ) is avascular jawbone necrosis due to the use of antiresorptive and/or antiangiogenic drugs. Today; antiresorptive and antiangiogenic drugs are frequently used in diseases such as osteoporosis, multiple myeloma, Paget's disease, and prevention of cancer metastases. Many alternative treatment methods have been proposed for MRONJ, which is increasingly common and can be difficult to resolve. Platelet-rich blood concentrates are one of these treatment methods. In the case we presented, we used L-PRF concentrate to prevent MRONJ and we achieved successful results.
References
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C, Hope S, Drudge-Coates L, Niepel D, Van den Wyngaert
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and best practice for prevention, diagnosis, and treatment.
Oral Surg Oral Med Oral Pathol Oral Radiol. 2019
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Bisphosphonate-related osteonecrosis of the jaws:
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PMID: 28936298; PMCID: PMC5601107.
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fibrin for the treatment of bisphosphonate-related
osteonecrosis of the jaw: a prospective feasibility study.
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Jamshidi S, Khazaei S. Complementarity of surgical
therapy, photobiomodulation, A-PRF and L-PRF for
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jaw (MRONJ): an animal study. BMC Oral Health. 2022
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PMID: 35717177; PMCID: PMC9206277.
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due to Simvastatin: An Unusual Case Report. World
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osteonecrosis of the jaw with the use of platelet-rich
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Maxillofac Surg. 2016;45(10):1256–1260. doi: 10.1016/j.
ijom.2016.04.010.
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Schoeffler C, Dohan SL, Dohan AJ, Mouhyi J, Dohan DM.
Platelet-rich fibrin (PRF): a second-generation platelet
concentrate. Part IV: clinical effects on tissue healing.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod.
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- Dohan Ehrenfest DM, de Peppo GM, Doglioli P,
Sammartino G. Slow release of growth factors and
thrombospondin-1 in Choukroun’s platelet-rich fibrin
(PRF): a gold standard to achieve for all surgical
platelet concentrates technologies. Growth Factors.
2009;27(1):63–69. doi: 10.1080/08977190802636713.
Odontom Cerrahisinde Bisfosfonat Osteonekrozunu Önlemek için L-PRF Kullanımı: Vaka Raporu
Year 2023,
Volume: 9 Issue: 2, 101 - 105, 31.08.2023
Melike Baygın Durak
,
Banu Gürkan Köseoğlu
Abstract
İlaca bağlı çene osteonekrozu (MRONJ), antirezorptif ve/veya antianjiyojenik ilaçların kullanımına bağlı avasküler çene kemiği nekrozudur. Günümüzde antirezorptif ve antianjiyojenik ilaçlar osteoporoz, multipl miyelom, Paget hastalığı gibi hastalıklarda ve kanser metastazlarının önlenmesinde sıklıkla kullanılmaktadır. Giderek yaygınlaşan ve tedavisi zor olabilen MRONJ için birçok alternatif tedavi yöntemi önerilmiştir. Trombositten zengin kan konsantreleri bu tedavi yöntemlerinden biridir. Sunduğumuz olguda MRONJ'u önlemek için L-PRF konsantresi kullandık ve başarılı sonuçlar elde ettik.
References
- Nicolatou-Galitis O, Schiødt M, Mendes RA, Ripamonti
C, Hope S, Drudge-Coates L, Niepel D, Van den Wyngaert
T. Medication-related osteonecrosis of the jaw: definition
and best practice for prevention, diagnosis, and treatment.
Oral Surg Oral Med Oral Pathol Oral Radiol. 2019
Feb;127(2):117-135. doi: 10.1016/j.oooo.2018.09.008.
Epub 2018 Oct 9. PMID: 30393090.
- Pichardo SE, Richard van Merkesteyn JP.
Bisphosphonate-related osteonecrosis of the jaws:
spontaneous or dental origin? Oral Surg Oral Med Oral
Pathol Oral Radiol. 2013;116:287–92.
- Drake MT, Clarke BL, Khosla S. Bisphosphonates:
mechanism of action and role in clinical practice. Mayo
Clin Proc. 2008; 83: 1032-1045
- Food and Drug Administration. “XGEVA (denosumab)
Prescribing information.” (2015).
- Miranda M, Gianfreda F, Raffone C, Antonacci D,
Pistilli V, Bollero P. The Role of Platelet-Rich Fibrin (PRF)
in the Prevention of Medication-Related Osteonecrosis
of the Jaw (MRONJ). Biomed Res Int. 2021 May
13;2021:4948139. doi: 10.1155/2021/4948139. PMID:
34095295; PMCID: PMC8140838.
- Cano-Durán JA, Peña-Cardelles JF, Ortega-Concepción
D, Paredes-Rodríguez VM, García-Riart M, López-
Quiles J. The role of Leucocyte-rich and platelet-rich
fibrin (L-PRF) in the treatment of the medication-related
osteonecrosis of the jaws (MRONJ). J Clin Exp Dent.
2017 Aug 1;9(8):e1051-e1059. doi: 10.4317/jced.54154.
PMID: 28936298; PMCID: PMC5601107.
- Kim JW, Kim SJ, Kim MR. Leucocyte-rich and plateletrich
fibrin for the treatment of bisphosphonate-related
osteonecrosis of the jaw: a prospective feasibility study.
Br J Oral Maxillofac Surg. 2014;52:854–59.
- Jamalpour MR, Shahabi S, Baghestani M, Shokri A,
Jamshidi S, Khazaei S. Complementarity of surgical
therapy, photobiomodulation, A-PRF and L-PRF for
management of medication-related osteonecrosis of the
jaw (MRONJ): an animal study. BMC Oral Health. 2022
Jun 18;22(1):241. doi: 10.1186/s12903-022-02275-2.
PMID: 35717177; PMCID: PMC9206277.
- Samieirad S, Labafchi A, Famili K, Hashemzadeh H.
Medication-Related Osteonecrosis of the Jaw (MRONJ)
due to Simvastatin: An Unusual Case Report. World
J Plast Surg. 2021 Jan;10(1):132-135. doi: 10.29252/
wjps.10.1.132. PMID: 33833966; PMCID: PMC8016372.
- Nørholt S, Hartlev J. Surgical treatment of
osteonecrosis of the jaw with the use of platelet-rich
fibrin: a prospective study of 15 patients. Int J Oral
Maxillofac Surg. 2016;45(10):1256–1260. doi: 10.1016/j.
ijom.2016.04.010.
- Choukroun J, Diss A, Simonpieri A, Girard M-O,
Schoeffler C, Dohan SL, Dohan AJ, Mouhyi J, Dohan DM.
Platelet-rich fibrin (PRF): a second-generation platelet
concentrate. Part IV: clinical effects on tissue healing.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod.
2006;101(3):e56–e60. doi: 10.1016/j.tripleo.2005.07.011.
- Dohan Ehrenfest DM, de Peppo GM, Doglioli P,
Sammartino G. Slow release of growth factors and
thrombospondin-1 in Choukroun’s platelet-rich fibrin
(PRF): a gold standard to achieve for all surgical
platelet concentrates technologies. Growth Factors.
2009;27(1):63–69. doi: 10.1080/08977190802636713.