Circadian Effects of Methamphetamine on Mouse Brain Biogenic Amines, Norepinephrine, Dopamine and Serotonin, by the Method of Simultaneous Analysis

Year 1985, Volume: 1 Issue: 3, 163 - 174, 30.12.1985

Kanji Yoshimoto

https://izlik.org/JA25GW46WE

Abstract

We have studied the chro opharrrıacodynamics, circadian variations of methamphetamine susceptibility, in mice. In control mouse, we observed that mouse brain biogenic amines, norepinephrine (NE),
dopamine (DA) and 5-hydroxytryptamine (serotonin, S-HT) are decreased in nocturnal and increased in diumal. Tbese data show circadian rhythms in the levels of brain biogenic amines. In mice treated with met hamphetamine (MAP) (5 mg/kg) subeutaneously, the sus eeptibility to MAP in the level of NE was similar to the pattem of a cireadian rhythm in control miee. In the level of DA, the susccptibility to MAP exhibited a bimodal pattem with peaks occurring during the light and dark phases of the circadian cycle. On the contrary, in the level of S-HT, the susceptibility to MAP does not recognize the differences resulting from daily flue tuations. The level of S-HT shows constant value s in both diumal and noctumal phases. From these results, it may be suggested that the chronotypic effects of MAP by itself were more sensitiye on serotonergic systems than noradrenergic system s in CNS mechanism. We have reconfirmed that the pharmacological and toxicological effects of JlIAP werc bigger in active phase than inactive or sleepy phasc. This resuIt in this paper may be related with the similarity to the anti-social behaviors and/or euphoria in human at the time of day when methamphetamine was intaked.

Keywords

Norepinephrine , Dopamine , Serotonin

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