Studies on in vitro Hemolytic Effect of Morphine Sulphate

Year 1988, Volume: 4 Issue: 3-4, 111 - 116, 31.08.1988

S. William

https://izlik.org/JA23YP29FY

Abstract

In vitro studies on hemolytic effect of morphine sulphate (MS) has been carried out on rat and human erythrocytes and are found to be susceptible to hemolysis. Comparatively human erythrocytes are most sensitive to hemolysis by MS. The degree of hemolysis is found to be dose dependenl. The depletion of glutathione and the increase in lipid peroxidation may be responsible for the disintegration of erythrocyte membrane. Erythrocytes preincubated with glucose and A TP proteet the celis against morphine induced lysis.

Keywords

Morphine sulphate, , Glucose and ATP , Hemolytic effect

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