Screening Procedure for 30 Antihistamines H1 Using Capillary Gas Chromatography - Mass Spectrometry

Abstract

Positive-ion electron impact and positive-ion chemical ionization mass spectra of 30 antihistamines H1 are presented. Drugs were extracted under alkaline conditions, and separated on a 25 m BP5 capillary column. GC retention times are reported on both a retention indices basis as well as relative to SKF 525 A internal standard. While mass spectra were sometimes identical in electron impact mode, particularly for the ion m/z 58, using chemical ionization mode, characteristic ions were obtained.

Keywords

• Antihistamines H1
• Forensic analysis
• Mass spectrometry

References

1. Halpern, RN. (1942) Arch. Int. PharfMcodyn. Ther., 68, 339.
2. Droin, M.A. (1985) Ann. Allergy, 55,747-752.
3. Backer, R.e., Pisllno, R.V., Sopher, I.M. (1977) 1. Anal. Toxicol., 1, 227-228.
4. Aderjan, R., Bosche, J., Schmidt, G. (1982) Z. Rechtsmed., 88,263-270.
5. Backer, R.e., Mc Feeley, P., Wohlcnbcrg, N. (1989) 1. Anal. Toxicol., 13, 308-309.
6. Spichlcr, V.R., Fukumoto, R.I. (1984) 1. Anal. Toxicol., 8, 242-243.
7. Kintz, P., Godelar, B., Mangin, P. (1990) Forensic Sci. Int., 48,139-143.
8. Maurer, H., Pfleger, K. (1988) 1. Chromatogr., 428, 43-60.

9. Maurer, H., Pfleger, K. (1988) Arch. Toxicol., 62, 185-191.
10. Maurer, H., Pfleger, K. (1988) 1. Chromatogr., 430, 31-41.