Screening Procedure for 30 Antihistamines H1 Using Capillary Gas Chromatography - Mass Spectrometry

Year 1991, Volume: 7 Issue: 3-4, 80 - 85, 31.08.1991

P. Kintz

https://izlik.org/JA49ZU28YA

Abstract

Positive-ion electron impact and positive-ion chemical ionization mass spectra of 30 antihistamines H1 are presented. Drugs were extracted under alkaline conditions, and separated on a 25 m BP5 capillary
column. GC retention times are reported on both a retention indices basis as well as relative to SKF 525 A internal standard. While mass spectra were sometimes identical in electron impact mode, particularly for the ion m/z 58, using chemical ionization mode, characteristic ions were obtained.

Keywords

Antihistamines H1 , Forensic analysis , Mass spectrometry

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