Genetik Faktörlerin Diş Çürüğü Üzerine Etkisinin Değerlendirilmesi

Yıl 2023, Cilt: 12 Sayı: 1, 135 - 141, 18.01.2023

Ecem Elif Çege , Nese Akal

https://doi.org/10.54617/adoklinikbilimler.1184104

Öz

Diş çürüklerinin enfeksiyöz ve multifaktöriyel bir hastalık olduğu bilinmektedir. Bireylerde diş çürüklerine yatkınlıkla ilişkili olduğu düşünülen bazı genetik faktörlerin varlığı uzun yıllar araştırılmıştır. Bu genetik temeller ailesel ve deneysel çalışmaların yanı sıra, monozigot ve dizigot ikizleri de kapsayan çalışmaları da içerir. Günümüze kadar diş çürüklerinin oluşumunda önemli rollere sahip muhtemel proteinler ve genler üzerinde çalışmalar yapılmıştır. Çalışılan genler arasında HLA genleri, mine formasyon genleri (örneğin AMELX geni) ve tükürük bileşenlerini oluşturan genler bulunmaktadır. Diş çürüklerinin artmasına veya azalmasına etkili olan genetik faktörlerin tanımlanması, diş hekimlerinin de daha etkili ve koruyucu tedaviler sunmalarına olanak sağlayacaktır.

Anahtar Kelimeler

Diş çürüğü, Genetik, Polimorfizm

Evaluation of the Effect of Genetic Factors on Dental Caries

Öz

Dental caries are known as infectious and multifactorial disease. The existence of some genetic factors thought to be associated with the susceptibility to dental caries in individuals has been investigated for many years. These genetic bases include familial and experimental studies as well as studies involving monozygotic and dizygotic twins. Until today, studies have been carried out on possible proteins and genes those have important roles in the formation of dental caries. Genes which have studied, include HLA genes, enamel formation genes (eg the AMELX gene), and genes those make up salivary components. Identification of genetic factors that affects the increase or decrease of dental caries will allow dentists to offer more effective and preventive treatments.

Anahtar Kelimeler

Dental caries, Genetics, Polymorphism

Kaynakça

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