Case Report
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Clinical findings of the coexistence of an extraluminal vaginal leiomyoma with ovarian cystadenoma in a dog

Year 2025, Volume: 14 Issue: 1, 37 - 41, 24.06.2025
https://doi.org/10.53913/aduveterinary.1627035

Abstract

In this report, we present a case of a dog diagnosed with both vaginal leiomyosarcoma and ovarian cystadenoma, which occurred concurrently with perioperative clinical findings. A twelve-year-old intact Siberian Husky bitch was brought to our clinic due to constipation and urination difficulties, attributed to a perineal mass that had been present for approximately one month. Although no tissue mass was visible protruding from the vagina, perineal swelling is remarkable, and the dog exhibited mild leukocytosis and anemia. Vaginal cytology showed densely keratinized superficial cells indicating high estrogen levels. Ultrasonography of the perineal and abdominal areas revealed a solid mass without internal blood flow, besides numerous cystic reflections in the left ovary. In surgery, after removing the two solid masses with episiotomy, the ovariohysterectomy was performed. Histopathological examination confirmed the diagnoses of vaginal leiomyosarcoma and ovarian cystadenoma. Following the operations, the patient regained normal urination and defecation and also recovered without complication and no recurrence.

References

  • Akkuş, T., Yaygıngül, R., Erdoğan, G., & Birincioğlu, S. S. (2016). Dişi bir köpekte reprodüktif benign kitleler ve inguinal fıtık olgusu. Harran Üniversitesi Veteriner Fakültesi Dergisi, 5(1), 80-83.
  • Brodzki, P., Wolniaczyk, K., Glodkowska, K., & Brodzki, N. (2023). Tumors of the reproductive system of bitches-based on the description of selected own clinical cases and literature data. Medycyna Weterynaryjna, 79(7), 334-344. http://dx.doi.org/10.21521/mw.6777
  • Carreira, R.P. & Pires, M.D.A. (2016). Ovarian cysts in dogs’ practice. In: L.V. Berhardt (Ed.), Advances in Medicine and Biology (pp. 1–23). Nova Science Publishers, New York, USA.
  • Devereaux, K.A. & Schoolmeester, J.K. (2019). Smooth Muscle Tumors of The Female Genital Tract. Surgical Pathology and Clinics, 12(2), 397-455. https://doi.org/10.1016/j.path.2019.02.004
  • Dhoke, V.S., Hedau, M., & Joshi, M.V. (2017). Cervico-Vaginal Multiple Leiomyomas in a Labrador Dog: A Case Report. Indian Journal of Veterinary Sciences and Biotechnology, 12(3), 65-66. https://doi.org/10.21887/ijvsbt.v12i3.7094
  • Diez-Bru, N., Garcia-Real, I., Martinez, E.M., Rollan, E., Mayenco, A. & Liorens, P. (1998). Ultrasonographic appearance of ovarian tumors in 10 dogs. Veterinary Radiology and Ultrasound, 39(3), 226-233.
  • Erdoğan, G. (2022). The gynecological controls in the elderly female dogs. Journal of the Hellenic Veterinary Medical Society, 73(1), 3583-3588. https://doi.org/10.12681/jhvms.25807
  • Feldman, E.C., & Nelson, R.W. (2004). Canine and Feline Endocrinology and Reproduction, 3rd, (pp:901-918), Saunders, Philadelphia, USA.
  • Ferré-Dolcet, L., Romagnoli, S., Banzato, T., Cavicchioli, L., Di Maggio, R., Cattai, A., & Mollo, A. (2020). Progesterone-responsive vaginal leiomyoma and hyperprogesteronemia due to ovarian luteoma in an older bitch. BMC Veterinary Research, 16, 284. https://doi.org/10.1186/s12917-020-02507-z
  • Herron, M.A. (1983). Tumors of the canine genital system. Journal of the American Animal Hospital Association, 19, 981-994.
  • James, F., Zans, M., & Donald, M.G. (2012). Pathology basis of veterinary disease. (5th edition), (pp. 1092), Elsevier http://evolve.elsevier.com.
  • Kang, T.B., & Holmberg, D.L. (1983). Vaginal leiomyoma in a dog. Canadian Veterinary Journal, 24, 258-260.
  • Klein, M.K. (2007). Tumors of the female reproductive system. In: S.J. Wihtrow, E.G., Macewem (Eds). Small animal clinical oncology, (pp. 610-618), Saunders, Philadelphia/USA.
  • MacLachlan, N.J., & Kennedy, P.C. (2002). Tumors of the genital system, In: M.J. Meuten, (Ed) Tumors in Domestic Animals. (pp: 547-573), Iowa State University Press, Iowa/USA.
  • McEntee, M.C. Reproductive oncology. (2002). Clinical Technics in Small Animal Practice, 17(3), 133-149.
  • Nelissen, P., & White, R.A.S. (2012). Subtotal vaginectomy for management of extensive vaginal disease in 11 dogs. Veterinary Surgery, 41(4), 495-500. https://doi.org/10.1111/j.1532-950X.2011.00948.x
  • Ozmen, O., Halıgur, Mehmet., & Kocamuftuoglu, M. (2008). Clinicopathologic and immunohistochemical findings of multiple genital leiomyomas and mammary adenocarcinomas in a bitch. Reproduction in Domestic Animals, 43(3), 377-381. https://doi.org/10.1111/j.1439-0531.2007.00917.x
  • Rollon, E., Millan, Y., Martin, J., & Mulas, D.L. (2008). Effects of aglepristone, a progesterone receptor antagonist in a dog with a vaginal fibroma. Journal of Small Animal Practice, 41-43. https://doi.org/10.1111/j.1748-5827.2007.00424.x
  • Root Kustritz, M.V. (2010). Clinical Canine and Feline Reproduction Evidence-Based Answers, Wiley-Blackwell.
  • Saikia, B., Bayan, H., Sarma, K., Talukdar, D., & Ahmed, F. A. (2018). Surgical management of vaginal leiomyoma in bitch. Theriogenology Insight-An International Journal of Reproduction in all Animals, 8(3),95-99.
  • Sathya, S., & Linn, K. (2014). Regression of a vaginal leiomyoma after ovariohysterectomy in a dog: a case report. Journal of American Animal Hospital Association, 50(6), 424-428. https://doi.org/10.5326/JAAHA-MS-6082
  • Schlafer, D., & Miller, R. (2007). Pathology of the ovary (Nondevelopmental lesions). In: M.G. M, (Ed.) Jubb, Kennedy & Palmer’s Pathology of Domestic Animals. (pp:444–450), Elsevier L. Elsevier, St Louis/USA.
  • Serin, G., Kara, M. E., & Serin, İ. (2006). Vulvo-vaginal Atresia in a Queen with Mammary and Uterine Tumors: Case Report. Uludağ Üniversitesi Veteriner Fakültesi Dergisi, 25(1-2), 19-21.
  • Singh, K., Bodh, D., Gopinathan, A., Mohsina, A., & Sangeetha, P. (2014). A case of concurrent inguinal hernia and vaginal leiomyoma in a bitch successfully treated surgically. Research Journal in Veterinary Practice, 2(1), 1-4. https://doi.org/10.14737/journal.rjvp/2014/2.1.1.4.
  • Umamageswari, J., Sridevi, P., Rangasamy, S., & Sridhar, R. (2016). Vaginal leiomyoma in a pregnant bitch. The Indian Journal of Animal Reproduction, 37(2), 71-73.
  • White, R.N., & Brearley, M. (2018). Tumours of the urogenital system. In: BSAVA Manual of Canine and Feline Oncology, In J.M. Dobson & B. D. X. Lascelles (Eds.). (pp:249-263), London/UK.
  • Yotov, S., Simeonov, R., Dimitrov, F., Vassilev, N., Dimitrov, M., & Georgiev, P. (2005). Papillary ovarian cystadenocarcinoma in a dog: clinical communication. Journal of the South African Veterinary Association, 76(1), 43-45.
  • Yuefei, Y., Xiaobo, W., & Yanhong, W. (2012). Vaginal masses in bitches: Surgical management and clinicopathologic report of 5 cases. Journal of Animal and Veterinary Advances, 11, 335–338.

Bir Köpekte Eşzamanlı Görülen Ekstraluminal Vajinal Leiomyoma ve Ovaryan Kistadenomanın Klinik Bulguları

Year 2025, Volume: 14 Issue: 1, 37 - 41, 24.06.2025
https://doi.org/10.53913/aduveterinary.1627035

Abstract

Bu raporda bir köpekte eşzamanlı görülen vajinal leiomyosarkom ve ovaryan kistadenoma olgusuna ait perioperatif klinik bulgular sunulmuştur. Kısırlaştırılmamış, 12 yaşlı Sibirya Kurdu cinsi dişi köpek yaklaşık bir aydır gözlenen perineal kitleye bağlı kabızlık ve idrar yapma güçlüğü şikayetiyle kliniğimize getirildi. Vajinadan dışarı çıkan bir kitle görülmemesine rağmen, köpekte perineal şişlik belirgindi, hafif lökositoz ve anemi tespit edildi. Vajinal sitolojide yüksek östrojen düzeyine işaret eden yoğun keratinize süperfisial hücreler görüldü. Perineal ve abdominal bölgenin ultrasonografik incelemesinde damarlaşma içermeyen solid bir kitle ve sol ovaryumda çok sayıda kistik yansıma gözlendi. Operasyon sırasında iki solid kitle epizyotomi ile çıkarıldıktan sonra ovariohisterektomi uygulandı. Histopatoloji incelemelerde vajinal leiomyosarkom ve over kistadenoması tanısı kondu. Operasyonları izleyen dönemde hasta normal idrar ve dışkılama fonksiyonlarını yeniden kazandı, komplikasyon yaşamadan ve nüks görülmeden iyileşti.

References

  • Akkuş, T., Yaygıngül, R., Erdoğan, G., & Birincioğlu, S. S. (2016). Dişi bir köpekte reprodüktif benign kitleler ve inguinal fıtık olgusu. Harran Üniversitesi Veteriner Fakültesi Dergisi, 5(1), 80-83.
  • Brodzki, P., Wolniaczyk, K., Glodkowska, K., & Brodzki, N. (2023). Tumors of the reproductive system of bitches-based on the description of selected own clinical cases and literature data. Medycyna Weterynaryjna, 79(7), 334-344. http://dx.doi.org/10.21521/mw.6777
  • Carreira, R.P. & Pires, M.D.A. (2016). Ovarian cysts in dogs’ practice. In: L.V. Berhardt (Ed.), Advances in Medicine and Biology (pp. 1–23). Nova Science Publishers, New York, USA.
  • Devereaux, K.A. & Schoolmeester, J.K. (2019). Smooth Muscle Tumors of The Female Genital Tract. Surgical Pathology and Clinics, 12(2), 397-455. https://doi.org/10.1016/j.path.2019.02.004
  • Dhoke, V.S., Hedau, M., & Joshi, M.V. (2017). Cervico-Vaginal Multiple Leiomyomas in a Labrador Dog: A Case Report. Indian Journal of Veterinary Sciences and Biotechnology, 12(3), 65-66. https://doi.org/10.21887/ijvsbt.v12i3.7094
  • Diez-Bru, N., Garcia-Real, I., Martinez, E.M., Rollan, E., Mayenco, A. & Liorens, P. (1998). Ultrasonographic appearance of ovarian tumors in 10 dogs. Veterinary Radiology and Ultrasound, 39(3), 226-233.
  • Erdoğan, G. (2022). The gynecological controls in the elderly female dogs. Journal of the Hellenic Veterinary Medical Society, 73(1), 3583-3588. https://doi.org/10.12681/jhvms.25807
  • Feldman, E.C., & Nelson, R.W. (2004). Canine and Feline Endocrinology and Reproduction, 3rd, (pp:901-918), Saunders, Philadelphia, USA.
  • Ferré-Dolcet, L., Romagnoli, S., Banzato, T., Cavicchioli, L., Di Maggio, R., Cattai, A., & Mollo, A. (2020). Progesterone-responsive vaginal leiomyoma and hyperprogesteronemia due to ovarian luteoma in an older bitch. BMC Veterinary Research, 16, 284. https://doi.org/10.1186/s12917-020-02507-z
  • Herron, M.A. (1983). Tumors of the canine genital system. Journal of the American Animal Hospital Association, 19, 981-994.
  • James, F., Zans, M., & Donald, M.G. (2012). Pathology basis of veterinary disease. (5th edition), (pp. 1092), Elsevier http://evolve.elsevier.com.
  • Kang, T.B., & Holmberg, D.L. (1983). Vaginal leiomyoma in a dog. Canadian Veterinary Journal, 24, 258-260.
  • Klein, M.K. (2007). Tumors of the female reproductive system. In: S.J. Wihtrow, E.G., Macewem (Eds). Small animal clinical oncology, (pp. 610-618), Saunders, Philadelphia/USA.
  • MacLachlan, N.J., & Kennedy, P.C. (2002). Tumors of the genital system, In: M.J. Meuten, (Ed) Tumors in Domestic Animals. (pp: 547-573), Iowa State University Press, Iowa/USA.
  • McEntee, M.C. Reproductive oncology. (2002). Clinical Technics in Small Animal Practice, 17(3), 133-149.
  • Nelissen, P., & White, R.A.S. (2012). Subtotal vaginectomy for management of extensive vaginal disease in 11 dogs. Veterinary Surgery, 41(4), 495-500. https://doi.org/10.1111/j.1532-950X.2011.00948.x
  • Ozmen, O., Halıgur, Mehmet., & Kocamuftuoglu, M. (2008). Clinicopathologic and immunohistochemical findings of multiple genital leiomyomas and mammary adenocarcinomas in a bitch. Reproduction in Domestic Animals, 43(3), 377-381. https://doi.org/10.1111/j.1439-0531.2007.00917.x
  • Rollon, E., Millan, Y., Martin, J., & Mulas, D.L. (2008). Effects of aglepristone, a progesterone receptor antagonist in a dog with a vaginal fibroma. Journal of Small Animal Practice, 41-43. https://doi.org/10.1111/j.1748-5827.2007.00424.x
  • Root Kustritz, M.V. (2010). Clinical Canine and Feline Reproduction Evidence-Based Answers, Wiley-Blackwell.
  • Saikia, B., Bayan, H., Sarma, K., Talukdar, D., & Ahmed, F. A. (2018). Surgical management of vaginal leiomyoma in bitch. Theriogenology Insight-An International Journal of Reproduction in all Animals, 8(3),95-99.
  • Sathya, S., & Linn, K. (2014). Regression of a vaginal leiomyoma after ovariohysterectomy in a dog: a case report. Journal of American Animal Hospital Association, 50(6), 424-428. https://doi.org/10.5326/JAAHA-MS-6082
  • Schlafer, D., & Miller, R. (2007). Pathology of the ovary (Nondevelopmental lesions). In: M.G. M, (Ed.) Jubb, Kennedy & Palmer’s Pathology of Domestic Animals. (pp:444–450), Elsevier L. Elsevier, St Louis/USA.
  • Serin, G., Kara, M. E., & Serin, İ. (2006). Vulvo-vaginal Atresia in a Queen with Mammary and Uterine Tumors: Case Report. Uludağ Üniversitesi Veteriner Fakültesi Dergisi, 25(1-2), 19-21.
  • Singh, K., Bodh, D., Gopinathan, A., Mohsina, A., & Sangeetha, P. (2014). A case of concurrent inguinal hernia and vaginal leiomyoma in a bitch successfully treated surgically. Research Journal in Veterinary Practice, 2(1), 1-4. https://doi.org/10.14737/journal.rjvp/2014/2.1.1.4.
  • Umamageswari, J., Sridevi, P., Rangasamy, S., & Sridhar, R. (2016). Vaginal leiomyoma in a pregnant bitch. The Indian Journal of Animal Reproduction, 37(2), 71-73.
  • White, R.N., & Brearley, M. (2018). Tumours of the urogenital system. In: BSAVA Manual of Canine and Feline Oncology, In J.M. Dobson & B. D. X. Lascelles (Eds.). (pp:249-263), London/UK.
  • Yotov, S., Simeonov, R., Dimitrov, F., Vassilev, N., Dimitrov, M., & Georgiev, P. (2005). Papillary ovarian cystadenocarcinoma in a dog: clinical communication. Journal of the South African Veterinary Association, 76(1), 43-45.
  • Yuefei, Y., Xiaobo, W., & Yanhong, W. (2012). Vaginal masses in bitches: Surgical management and clinicopathologic report of 5 cases. Journal of Animal and Veterinary Advances, 11, 335–338.
There are 28 citations in total.

Details

Primary Language English
Subjects Veterinary Sciences (Other)
Journal Section Case Report
Authors

Güneş Erdoğan 0000-0002-9807-810X

Publication Date June 24, 2025
Submission Date January 25, 2025
Acceptance Date March 26, 2025
Published in Issue Year 2025 Volume: 14 Issue: 1

Cite

APA Erdoğan, G. (2025). Clinical findings of the coexistence of an extraluminal vaginal leiomyoma with ovarian cystadenoma in a dog. Animal Health Production and Hygiene, 14(1), 37-41. https://doi.org/10.53913/aduveterinary.1627035