The Role of Mortierella spp. In Mycotic Infections and Using of In Different Fields

Abstract

Background/ Aim: Mortierella infection there is seen almost exclusively in dairy cows and is typically associated with feeding moldy hay and ensilage. About 90 species of Mortierella are known and they caused to bovine mycotic abortion, hepatitis, meningoencephalitis, pneumonia and systemic mycosis. Also they have been isolated in phycomycoses of man and animals, from tracheal lesions in chickens and from horses with granular dermatitis. The aim of this study is to inform about the role of Mortierella species in mycotic infections.Conclusion: Mortierella colonies are in generally white to light-grey and occurring garlic-like odour on the agar. Species of the genus are usually non-pathogenic for plants and humans. Within the genus Mortierella, the only known antibiotic is fusidic acid or ramycin , produced by some strains of M. ramanniana. EPA Eicosapentaenoic acid has been shown to be of major importance in the prevention and treatment of a range of human diseases and disorders.

Keywords

• Mortierella spp.,Mycotis Infections

Mortierella Türlerinin Mikotik Enfeksiyonlardaki Rolü ve Farklı Alanlarda Kullanımı

Öz

Özbilgi/Amaç: Mortierella enfeksiyonu genellikle küflü saman ve silaj ile beslenen süt ineklerinde görülmektedir. Mortierella’nın yaklaşık 90 türü bilinmektedir ve sığır mikotik abort, hepatit, meningoensefalit, pnömoni ve sistemik mantar enfeksiyonlarına neden olmaktadırlar. Ayrıca tavuk ve granül dermatiti olan atların trakeal lezyonlarından, fikomikozis görülen insan ve hayvanlardan da izole edilmiştir. Çalışmanın amacı, Mortierella türlerinin mikotik enfeksiyonlardaki rolü hakkında bilgi vermektir.Sonuç: Mortierella kolonileri genelde beyaz ile açık gri arasındadır ve agarda sarımsak benzeri bir koku meydana getirirler. Mortierella cinsinin türleri genellikle bitkiler ve insanlar için patojenik değildir ve sadece antibiyotik olarak bilinen fusidik asit M. ramanniana’nın bazı suşları tarafından üretilmektedir. Tür tarafından üretilen EPA Eikozapentaenoik asit insanlarda hastalıkların tedavisi ve önlenmesinde önem taşımaktadır.

Anahtar Kelimeler

• Mortierela spp.,Mikotik Enfeksiyonlar

References

1. Austwick PKC (1973). Mycotic abortion. In: Fungal diseases of animals, Common-wealth Agriculture Bureau, Famham Royal, Slough, Eng- land, 2nd ed, pp. 74-80.
2. Bajpai P, Bajpai PK and Ward OP (1991). Eicosapentaenoic acid (EPA) formation: comparative studies with Mortierella strains and pro- duction by Mortierella elongate. Mycological Research, 95, 1294– 1298.
3. Chesters CGC and Peberdy JF (1965). Nutritional factors in relation to growth and fat synthesis in Mortierella vinacea. Journal of General Microbiology, 41, 127–134.
4. Cordes DO, Di Menna ME and Carter ME (1972). The identification of Mortierella wolfii isolated from cases of abortion and pneumonia in cattle and a search for its infection source. Research in Veterinary Science, 13, 439–442.
5. Cordes DO, Di Menna ME and Carter ME (1972). Mycotic pneumonia and placentitis caused by Mortierella wolfii. Experimental infection in cattle and sheep. Veterinary Pathology, 9, 131-141.
6. Cordes DO, Royal WA and Shortridge EH (1967). Systemic mycosis in neonatal calves. New Zealand Veterinary Journal, 15, 143-149.
7. Cordes DO, Di Menna ME and Carter ME (1972). Mycotic Pneumonia and Placentitis Caused by Mortierella wolfii I. Experimental Infecti- ons in Cattle and Sheep. Veterinary Pathology, 9, 131-141.
8. Carrasco L, Tarradas MC, Gomez Villamandos JC, Luque I, Arenas A and Mendez A (1997). Equine Pulmonary Mycosis due to Aspergillus ni- ger and Rhizopus stolonifer. Journal of Comparative Pathology, 117, 19l-199.

9. Davies JL, Ngeleka M and Wobeser GA (2010). Systemic infection with Mortierella wolfii following abortion in a cow. Canadian Veterinary Journal, 51, 1391-1393.
10. Davey G, Smith JMB and Kalmakoff J (1973). Purification and Properties of a Toxin Isolated from Mortierella wolfii. Infection and Immunity, 8(6), 882-886.
11. Park RY, Koike Y, Cai HJ, Higashiyama K and Fujikawa S (2001). Morpho- logical Diversity of Mortierella alpina: Effect of Consumed Carbon to Nitrogen Ratio in Flask Culture Biotechnol. Biotechnology and Bioprocess Engineering, 6, 161-166.
12. Gabor LJ (2003). Mycotic pneumonia in a dairycow caused by Mortie- rella wolfii. Australian Veterinary Journal, 81, 409–410.
13. Umemoto H, Sawada K, Kurata A, Hamaguchi S, Tsukahara S, Ishiguro S and Kishimoto N (2014). Fermentative Production of Nervonic Acid by Mortierella capitata, Journal of Oleo Science, 11; 63(7), 671-679.
14. Hussein MR (2008). Mucocutaneous Splendore-Hoeppli phenomenon. J Cutan Pathol, 35(11), 979-988.
15. Knudtson WU and Kirkbride CA (1992). Fungi associated with bovine abortion in the northern plains states (USA). Journal of Veterinary Diagnostic Investigation, 4,181-185.
16. Lanting CIVF, Huisman M, Touwen BCL and Boersma ER (2003). Long-c- hain polyunsaturated fatty acids have a positive effect on the qua- lity of general movements of healthy term infants. The American Journal of Clinical Nutrition, 78, 2, 313-318.
17. Margaret MC and Koske RE (1992). Room Temperature Isolations Can Bias Against Selection of Low Temperature Microfungi in Temperate Forest Soils. Mycologia, 84, 6, 886-900.
18. Murphy M (2002). Molds and Mycotoxins. Current Therapy in Equine Medicine, 5th Edition: 22, 9.
19. Martin C and Baldauf SL (2011). The Protistan Origins of Animals and Fungi, Evolution of Fungi and Fungal-Like Organisms. The Mycota XIV, Springer-Verlag Berlin.
20. Arda M (2006). Temel Mikrobiyoloji, Medisan, p.315-329.
21. Pachauri S, Varshney P, Dash SK and Gupta MK (2013). Involvement of fungal species in bovine mastitis in and around Mathura, India, Vet World 6(7):393-395.
22. Reiss J (1993). Biotoxic activity in the Mucorales. Mycopathologica 121, 123–127.
23. Roland WSW and Tribe HT (2003). Oil as a substrate for Mortierella species. Mycologist, Volume 17, Aug, Part 3.
24. Ali R and Khan IH (2006). Mycotic Abortion in Cattle. Pakistan Veteri- nary Journal, 26(1), 44-46.
25. Roden MM, Zaoutis TE, Buchanan WL, Knudsen TA, Sarkisova TA, Scha- ufele RL, Sein M, Sein T, Chiou CC, Chu JH, Kontoyiannis DP and Wal- sh TJ. (2005). Epidemiology and outcome of zygomycosis: a Review of 929 reported cases. Clinical Infectious Diseases, 41,634–653.
26. Sponsler TA, Sassani JW, Johnson LN and Towfighi (1992). J: Ocular inva- sion in mucormycosis. Survey of Ophthalmology, 36, 345-350.
27. Streekstra H (1997). On the safety of Mortierella alpina for the produ- ction of food ingredients, such as arachidonic acid. Journal of Biote- chnology, 56, 153–165.
28. Wada S, Ode S, Hobo S, Niwa H, Katayama Y and Takatori K (2011). Mor- tierella wolfii keratomycosis in a horse. Veterinary Ophthalmology, 14, 4, 267–270.
29. Petkovits T, Nagy LG, Hoffmann K, Wagner L, Nyilasi I, Griebel T, Sch- nabelrauch D, Vogel H, Voigt K, Vágvölgyi C and Papp T (2011). Data Partitions, Bayesian Analysis and Phylogeny of the Zygomyce- tous Fungal Family Mortierellaceae, Inferred from Nuclear Riboso- mal DNA Sequences. Volume 6, Issue 11.
30. Gams W and Degawa Y (2004). A new species of Mortierella, and an associated sporangiiferous mycoparasite in a new genus, Notha- delphia. Studies in Studies in Mycology, 50, 567–572.
31. Stielow WL, Hoffmann BK, Petkovits T, Papp T, Vágvölgyi C, de Hoog GS, Verkley G and Voigt K (2013). A comprehensive molecular phy- logeny of the Mortierellales (Mortierellomycotina) based on nucle- ar ribosomal DNA. Persoonia 30, 77–93.
32. Webster J and Weber RWS (2007). Introduction to fungi. Cambridge University Press, p.197-200.