Cancer Stem Cell

Year 2016, Volume: 5 Issue: 1, 416 - 422, 01.01.2016

Ayşe Nur Akkoç Nihat Toplu

Abstract

Backround/Aim: Throughout the history, there has been numerous studies about how cancer is formed and which treatments are need to be done since the term of cancer has been accepted. The failure of existing treatments to prevent and destroy cancer has led to the creation of new theories. Since the cancer mass is not completely destroyed and due to the idea of ​​a birth center responsible for reestablishing itself cancer stem cell CSC concept has emerged. In the last 30 years, the results of studies to prove this support the cancer stem cell theory. The theory will change the standards of care and alternative methods will be a new light in the solution of this disease at all stages starting with protection from cancer. In this review, cancer stem cells, current studies and benefits provided for these studies have been discussed. Conclusion: Information on how cancer stem cell theory will govern treatment is still limited because there is little information about cancer stem cell markers, treatments targeting cancer stem cells are in the early stages, and side effects are unknown. Therefore, more specific markers should be found and their roles should be better understood and therapy strategies should be developed accordingly. When appropriate markers of CSC are available, it seems possible to develop cancer stem cell-specific therapies that will keep healthy stem cells separate and have fewer side effects.

Keywords

Cancer, Cancer stem cell, stem cell.

Kanser Kök Hücresi

Abstract

Özbilgi/Amaç: Tarih boyunca, kanser kavramı kabul edildiğinden beri, neden oluştuğu ve nasıl tedavi edileceği üzerine çok sayıda çalışma ortaya koyulmuştur. Mevcut tedavilerin kanseri önlemede ve yok etmedeki başarısızlığı yeni teorilerin oluşmasına yol açmıştır. Kanser kitlesinin tamamiyle yok edilememesi ve kendini tekrar oluşturmasından sorumlu bir doğurucu merkez düşüncesi ile kanser kök hücresi KKH kavramı ortaya çıkmıştır. Son 30 yılda bunu kanıtlamaya yönelik yapılan çalışmalarla ortaya konulan sonuçlar bu teoriyi desteklemektedir. KKH teorisi ile tedavideki standartlar değişecek ve alternatif yöntemler kanserden korunmayla başlayan tüm aşamalarda bu hastalığın çözümünde yeni bir ışık olacaktır. Bu derlemede kanser kök hücreleri, mevcut çalışmalar ve bu çalışmalar doğrultusunda sağlanan faydalar konu edilmiştir. Sonuç: KKH belirteçlerine dair henüz az bilgi olması, KKH’ni hedef alan terapilerin iyi sonuçlarına rağmen daha başlangıç aşamasında olması ve yan etkilerinin az bilinmesi nedeniyle KKH teorisinin tedaviye vereceği yön hakkındaki bilgiler henüz sınırlıdır. Bu yüzden daha spesifik belirteçler bulunmalı ve bunların rolleri daha iyi anlaşılmalı ve terapi stratejileri buna göre geliştirilmelidir. Uygun KKH belirteçleri bulunduğu zaman sağlıklı kök hücrelerini ayrı tutacak, yan etkileri azaltılmış ve KKH’ne spesifik terapiler geliştirilmesi mümkün görünmektedir.

Keywords

Kanser, Kanser kök hücresi, kök hücre

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