Generalize ve lokal alopesili köpeklerde melatonin implantı tedavisi

Year 2015, Volume: 4 Issue: 1, 359 - 363, 01.01.2015

Kerem Ural Canberk Balıkçı1 Ümit Karademir Mehmet Gültekin İbrahim Akın , Adnan Ayan

Abstract

Özbilgi/Amaç: Kıl kaybı alopesi , hayvanın hayatı boyunca herhangi bir dönemde var olabilen kompleks bir fenomendir. Alopesi, hayvanlarda sık görülmekle birlikte yıldırıcı bir bozukluktur. Bakteriyal, fungal, parazitik enfeksiyonlar, alerji/atopi, endokrin bozuklukları/hastalıkları ve kongenital/genetik bozuklukların tamamı gibi kıl büyümesine etki eden durumlar, alopesi oluşumuna neden olabilmektedir. Melatonin’in antioksidan etkisi göz önüne alındığında, muhtemelen deri biyolojisinde rol oynayabilir. Elde edilen bulgular melatoninin kıl büyümesini stimule ettiğini göstermekte ve çeşitli araştırmalar anılan hormonun köpeklerde alopesiye karşı kullanılmasını önermekteyken, topikal veya subkutanöz kullanımına ilişkin çalışmalar eksiktir. Anılan nedenlerden ötürü bu çalışmanın amacı farklı etiyolojik nedenlere bağlı alopesi mevcut köpeklerde sağaltım amacıyla subkutanöz uygulanan yavaş salınımlı melatonin implantının retrospektif sonuçlarını bildirmekti. Materyal ve Metot: Çalışma 2 ana gruba ayrılan köpeklerde gerçekleştirildi: grup I’de göğüste mevsimsel alopesi, demodikozis ya da atopik dermatitis’e bağlı generalize alopesi saptanan 5 köpek mevcuttu. Grup II’deki 3 köpekte ise lokal alopesi sarkoptik uyuza bağlı bulunmaktaydı. Tanı amaca uygun testler kullanılarak konuldu. Sonrasında tüm köpeklere, ortak klinik bulgu olan alopesinin sağaltımı amacıyla subkutanöz melatonin implantı uygulandı. Melatonin implantını takiben meydana gelen klinik iyileşme kılların tekrar büyümesi ve yeni şekillenen kılların klinik skorlaması baz alınarak yapıldı. Bulgular ve Sonuç: Grup I’deki 5 köpekten 4’ünde belirgin bir şekilde tam kıl büyümesi 6.-9. haftalar arasında gerçekleşti. Sağaltım öncesi 5 köpeğin alopesik klinik skorlaması 1 iken, sağaltım sonrası 10. hafta ise 5 köpeğin 4’ünde tam kıl büyümesi sebebiyle 3 olarak belirlendi. Sarkoptik uyuzlu köpeklerin oluşturduğu diğer grupta ise 10. haftadaki alopesik klinik skor kısmi ya da tam kıl büyümesinden dolayı 2 ya da 3 idi. Subkutaöz melatonin sağaltımı sonucu kıl büyümesinin klinik iyileşmeyi gösterdiği gibi bu yöntem pratik olarak mümkün olabilmektedir. Uygulama sırasında herhangi bir yan etki saptanmadı. Farklı etiyolojiye sahip alopesili köpeklerde, melatonin implantının güvenle kullanılabileceği söylenebilinir.

Keywords

Melatonin, implant, alopesi, köpek

Melatonin Implant for Treatment of Generalized and Localized Alopecia in Dogs

Abstract

Background/Aim: Hair loss alopecia is a complex phenomenon, that may be exist during the lifetime of the animal. Alopecia is a common, on the other hand frustrating disorder in companion animals. Bacterial, fungal and parasitic infections, allergy/atopy, endocrine disease/imbalances and congenital/genetic disorders of hair growth all might contribute to occurence of alopecia. Given the antioxidant effects for melatonin, it might probably has a role within the skin biology. Available evidence suggested that melatonin is capable of modulating hair growth and several researches indicated its usage against alopecia for dogs, whereas detailed studies regarding its topical or subcutaneous usage are lacking. Therefore the purpose of the present study was to report the retrospective results of subcutaneous slow release melatonin implant for treatment of alopecia due to different etiologies among dogs. Material, Methods: In a susbset of two major groups of dogs were studied: group I consisted of 5 dogs presented with generalized alopecia; consisting seasonal flank alopecia, demodicosis and atopic dermatitis. Group II consisted of 3 dogs presenting local alopecia sarcoptic mange . Diagnosis was based on relevant tests for all dogs. Afterwards all dogs underwent subcutaneous melatonin implant for treatment of common clinical sign, alopecia. Clinical recovery following melatonin impant was deemed on hair re-growth and quality of new hair, by clinical scoring. Results/Conclusion: Complete hair growth was evident in 4 out of 5 dogs involved in group I in 6 to 9 weeks. Prior to treatment all 5 dogs presented alopecic clinical scores as 1, where as after melatonin treatment on week 10 4 dogs were annotated as score 3, because of complete hair growth. In other group involving dogs with Sarcoptic mange week 10 scores presented as score 2 or 3, because of partial to complete hair growth. Clinical recovery as deemed by hair regrowth caused by subcutaneous treatment might be practically available. During applications no adverse effect was noticed. It may be suggested that melatonin implant may be safely used in dogs with alopecia due to different etiologies.

Keywords

Melatonin, implant, alopecia, dog

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