Case Report
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Year 2021, Volume: 10 Issue: 1, 27 - 32, 11.06.2021

Firdevs Binli , Serhan Ay , Gülşah Saral Sebati Sinan Ürkmez , Efe Karaca , Ishtiaq Ahmed Murat Fındık

Abstract

Transmissible veneral tümör (TVT) olguları %5 oranında vücudun farklı bölümlerine metastaz yapmaktadır. Sunulan olguda dişi bir Alman Çoban köpeğinde TVT’nin ovaryuma metastazı ve klinik görünümü anlatılmaktadır. Uzun süreli kanlı vaginal akıntı şikayetiyle getirilen olgunun vaginal duvarınının dorsalinde 3x1x1 cm çapında kitle belirlendi. Vaginal sitolojide TVT hücreleri görüldü. Ultrasonografik muayenede sol böbreğin kaudalinde, kenarları düzensiz bir kitle tespit edildi. Ovaryohisterektomi sonrası ölçümlerde kitlenin 9x11 cm boyutlarında olduğu belirlendi. Kitlenin metastaz sonucu şekillenme ihtimali nedeniyle, her iki kitlenin karşılaştırılması amacıyla, vaginal kitle de alınarak histopatolojik değerlendirmeye gönderildi. Değerlendirme sonucunda her iki kitlenin de TVT olduğu belirlendi. Yaptığımız araştırma sonucuna göre, sunulan olgu TVT’nin sadece ovaryuma metastaz yaptığı ilk olgu olma özelliğindedir.

Keywords

köpek ovaryum metastazı stiker sarkomu

References

  • Adams E.W., & Slaughter L.J. (1970). A canine veneral tumour with metastasis to the brain. Pathologia Veterinaria, 7, 498- 502. https://doi.org/10.1177/030098587000700604
  • Ayyappan S., Suresh Kumar R., Ganesh T.N., & Archibald David W.P. (1994). Metastatic transmissible venereal tumour in a dog. A case report. Indian Veterinary Journal, 71, 265-266.
  • Baştan A., Acar D.B., & Cengiz M. (2008). Uterine and ovarian metastasis of transmissible venereal tumor in a bitch. Turkish Journal of Veterinary and Animal Sciences, 32(1), 65-66.
  • Behera S., Kurade N., Monsang S., Das D., Mishra K., & Mohanta R.K. (2012). Clinico-pathological findings in a case of canine cutaneous metastatic transmissible venereal tumor. Veterinarski Arhiv, 82(4), 401-410.
  • Bhatia A., Tank P., Kavechiya V., Vedpathak H., & Karle A. (2010). Clinical management of canine transmissible venereal granuloma in dogs. Indian Journal of Field Veterinarians, 5(4),1-4.
  • Boscos C.M. & Ververidis H.N. (2004) Canine TVT—clinical findings, diagnosis and treatment. Proceedings of the 29th World Congress of the World Small Animal Veterinary Association.https://www.vin.com/apputil/content/defaultadv1.aspx?meta=Generic&pId=11181&id=3852301
  • Brodey R.S. & Roszel J.F. (1967). Neoplasms of the canine uterus, vagina and vulva: A clinicopathologic survey of 90 cases. Journal of American Veterinary Medical Association. 151, 1294-1307.
  • Chikweto A., Kumthekar S., Larkin H., Deallie C., Tiwari K.P., Sharma R.N., & Bhaiyat M.I. (2013). Genital and extragenital canine transmissible venereal tumor in dogs in Grenada, West Indies. Open Journal of Veterinary Medicine, 3, 111-114. 0.4236/ojvm.2013.32018
  • Cullen J.M., Page R., & Misdorp W. (2008). An overview of cancer pathogenesis, diagnosis, and management. In: Meuten D.J. (Ed), Tumors in Domestic Animals. 4th ed. (pp. 1-44). Blackwell.
  • Das U., Das A.K., Das D., & Das B.B. (1991). Clinical report on the efficacy of chemotherapy in canine transmissible venereal sarcoma. The Indian Veterinary Journal, 68, 249-252.
  • Das U., & Das A.K. (2000). Review of canine transmissible venereal sarcoma. Veterinary Research Communications, 24, 545-556. https://doi.org/10.1023/A:1006491918910
  • Feldman E., & Nelson R.W. (2004). Brucellosis and transmissible venereal tumor. In: E. Feldman E., & R.W. Nelson (Eds), Canine and Feline Endocrinology and Reproduction (3rd ed). (pp. 919-927). Saunders Elsevier.
  • Ganguly B., Das U., & Das A.K. (2013). Canine transmissible venereal tumour: a review. Veterinary and Comparative Oncology, 14(1), 1-12. 10.1111/vco.12060
  • Gurel A., Kuscu B., Gulanber E.G. & Arun S.S. (2002). Transmissible venereal tumors detected in the external genital organs of dog. Israel Journal of Veterinary Medicine, 57(2), 1-2.
  • Higgins D.A. (1966). Observations on the canine transmissible venereal tumour as seen in the Bahamas. Veterinary Record, 79, 67-71.
  • Hoque M. (2002). An update on canine transmissible venereal tumor. Intas Polivet. 3(2), 227-234.
  • Kabuusu R., Stroup D., & Fernandez C. (2010). Risk factors and characteristics of canine transmissible venereal tumours in Grenada, West Indies. Veterinary and Comparative Oncology, 8, 50-55. 10.1111/j.1476-5829.2009.00204.x
  • Kennedy P.C., Cullen J.M., Edwards J.F., Goldschmidt M.H., Larsen S., Munson L. & Nielsen S. (1998). Tumors of the ovary. In: P.C. Kennedy (Ed), Histological classification of tumors of the genital system of domestic animals. (2nd ed), (pp 24-28), Vol IV. Armed ForcesInstitute of Pathology, Washington.
  • Klein M.K. (1996). Tumors of the female reproductivesystem. In: S.J.Withrow and E.G. MacEwen (Eds). Small Animal Clinical Oncology (2nd ed) (pp 347-355). W.B. Saunders, Philadelphia.
  • Milo J., & Snead E. (2014). A case of ocular canine transmissible venereal tumor. The Canadian Veterinary Journal, 55(1), 1245-1249.
  • Maclachlan N.J., & Kennedy P.C. (2008). Tumors of the genital systems. In: D.J. Meuten (Ed), Tumors in Domestic Animals (4th ed). (pp. 547-573). Blackwell.
  • Martins MIM., Souza F.F., & Gobello C. (2005). The canine transmissible venereal tumor: etiology, pathology, diagnosis and treatment. In: P.W. Concannon, G. England, J. Verstegen, C. Linde Forsberg (Eds), Recent Advances in Small Animal Reproduction (2nd ed). (pp. 161-167). International Veterinary Information Service.
  • Murchison E.P. (2008). Clonally transmissible cancers in dogs and Tasmanian devils. Oncogene, 27(2), 19-30. 10.1038/onc.2009.350
  • Murgia C., Pritchard J.K., Kim S.Y., Fassati A., & Weiss R.A. (2006). Clonal origin and evolution of a transmissible cancer. Cell Cycle, 126(3), 377-487. 10.1016/j.cell.2006.05.051
  • Ramaswamy S., Ross K.N., Lander E.S., & Golub T.R. (2003). A molecular signature of metastasis in primary solid tumors. Nature Genetics, 33, 49-54. 10.1038/ng1060
  • Robbins M. (2003). Reproductive oncology. In: D. Slatter (Ed). Textbook of Small Animal Surgery (3rd ed). (pp. 2437-2444). Saunders Elsevier.
  • Savadkoohi H.S., Dehghani S., Namazi F., Khafi M.A., & Jalali Y. (2013). Electrosurgical excision of a large uniform transmissible venereal tumor (TVT) in a spayed bitch: a case report. Journal of Animal and Poultry Sciences, 2(2), 60-64.
  • Smith C.A. (2003). Ovarian disorders of the bitch and queen. In: M.R.V. Kustritz (Ed), Small Animal Theriogenology (1st ed). (pp. 331-365) Saunders Elsevier.
  • Sontaş H., Altun D., Yılmaz Ö., Arun S., Şenünver A., & Eki̇ci̇ H. (2010). Concomitant occurrence of ovarian remnant syndrome, transmissible venereal tumor and stump pyometra in a bitch. Kafkas Universitesi Veteriner Fakultesi Dergisi, 16(4), 675-680. 10.9775/kvfd.2009.1185
  • Temitope A.A., Adetola A.R., Folashade M.A., Olutayo O.T., Edem A.R., Olubukola N.H. & Babajide K.O. (2010). Radiographic assessment of canine transmissible venereal tumor metastases. Communications in Theriogenology, 4(1), 1.
  • Özyurtlu N., Bademkıran S., Ünver Ö., Yıldız F. & İçen H. (2008). Dişi bir köpekte transmissible venereal tümörün abdominal ve subkutan inguinal bölgeye metastazı. Dicle Üniversitesi Veteriner Fakültesi Dergisi, 1(2), 48-51.
  • Uçmak Z.G., 1, Kırşan İ., Uçmak M., Erdoğan Bamaç Ö. & Gürel A. (2019). Clinical approaches for genital and extragenital metastasis of transmissible venereal tumor in a bitch with ovarian remnant syndrome Ankara Üniversitesi Veteriner Fakültesi Dergisi, 66, 417-421. 10.33988/auvfd.568858
  • Veer L.J., Dai H., Vijver M.J., He Y.D., Hart A.A., Mao M., Peterse H.L., Kooy K., Marton M.J., Kitteveen A.T., Schreiber G.J., Kerkhoven R.M., Roberts C., Linsley P.S., Bernards R., & Friend S.H. (2002). Gene expression profiling predicts clinical outcome of breast cancer. Nature, 415, 530-535. 10.1038/415530a

Ovarian Metastatic Transmissible Venereal Tumour in a Dog – a case report and review

Year 2021, Volume: 10 Issue: 1, 27 - 32, 11.06.2021

Firdevs Binli , Serhan Ay , Gülşah Saral Sebati Sinan Ürkmez , Efe Karaca , Ishtiaq Ahmed Murat Fındık

Abstract

Approximately 5% of transmissible venereal tumour cases can metastatize to various parts of the body. The case presented explains the clinical appearance and histopathology results of the ovarian metastasis of TVT in a female German shepherd. The bitch was brought to the teaching hospital of Ondokuz Mayıs University, Faculty of Veterinary Medicine with a vaginal discharge. A mass with a diameter of 3x1x1 cm was detected on the dorsal vaginal wall. In vaginal cytology, the presence of TVT cells were determined. During ultrasonographic evaluation a mass was detected caudal to the left kidney with irregular margins. The dimension of the mass after ovariohysterectomy was found to be 9 x 11 cms. Because it was necessary to investigate the possibility of metastasis and to make comparison, the vaginal mass was also removed and sent for histopathological examination and both masses were identified as TVT. According to our knowledge this is the first report presenting a case of TVT with solely ovarian metastasis.

Keywords

bitch ovarian metastasis sticker's sarcoma

References

  • Adams E.W., & Slaughter L.J. (1970). A canine veneral tumour with metastasis to the brain. Pathologia Veterinaria, 7, 498- 502. https://doi.org/10.1177/030098587000700604
  • Ayyappan S., Suresh Kumar R., Ganesh T.N., & Archibald David W.P. (1994). Metastatic transmissible venereal tumour in a dog. A case report. Indian Veterinary Journal, 71, 265-266.
  • Baştan A., Acar D.B., & Cengiz M. (2008). Uterine and ovarian metastasis of transmissible venereal tumor in a bitch. Turkish Journal of Veterinary and Animal Sciences, 32(1), 65-66.
  • Behera S., Kurade N., Monsang S., Das D., Mishra K., & Mohanta R.K. (2012). Clinico-pathological findings in a case of canine cutaneous metastatic transmissible venereal tumor. Veterinarski Arhiv, 82(4), 401-410.
  • Bhatia A., Tank P., Kavechiya V., Vedpathak H., & Karle A. (2010). Clinical management of canine transmissible venereal granuloma in dogs. Indian Journal of Field Veterinarians, 5(4),1-4.
  • Boscos C.M. & Ververidis H.N. (2004) Canine TVT—clinical findings, diagnosis and treatment. Proceedings of the 29th World Congress of the World Small Animal Veterinary Association.https://www.vin.com/apputil/content/defaultadv1.aspx?meta=Generic&pId=11181&id=3852301
  • Brodey R.S. & Roszel J.F. (1967). Neoplasms of the canine uterus, vagina and vulva: A clinicopathologic survey of 90 cases. Journal of American Veterinary Medical Association. 151, 1294-1307.
  • Chikweto A., Kumthekar S., Larkin H., Deallie C., Tiwari K.P., Sharma R.N., & Bhaiyat M.I. (2013). Genital and extragenital canine transmissible venereal tumor in dogs in Grenada, West Indies. Open Journal of Veterinary Medicine, 3, 111-114. 0.4236/ojvm.2013.32018
  • Cullen J.M., Page R., & Misdorp W. (2008). An overview of cancer pathogenesis, diagnosis, and management. In: Meuten D.J. (Ed), Tumors in Domestic Animals. 4th ed. (pp. 1-44). Blackwell.
  • Das U., Das A.K., Das D., & Das B.B. (1991). Clinical report on the efficacy of chemotherapy in canine transmissible venereal sarcoma. The Indian Veterinary Journal, 68, 249-252.
  • Das U., & Das A.K. (2000). Review of canine transmissible venereal sarcoma. Veterinary Research Communications, 24, 545-556. https://doi.org/10.1023/A:1006491918910
  • Feldman E., & Nelson R.W. (2004). Brucellosis and transmissible venereal tumor. In: E. Feldman E., & R.W. Nelson (Eds), Canine and Feline Endocrinology and Reproduction (3rd ed). (pp. 919-927). Saunders Elsevier.
  • Ganguly B., Das U., & Das A.K. (2013). Canine transmissible venereal tumour: a review. Veterinary and Comparative Oncology, 14(1), 1-12. 10.1111/vco.12060
  • Gurel A., Kuscu B., Gulanber E.G. & Arun S.S. (2002). Transmissible venereal tumors detected in the external genital organs of dog. Israel Journal of Veterinary Medicine, 57(2), 1-2.
  • Higgins D.A. (1966). Observations on the canine transmissible venereal tumour as seen in the Bahamas. Veterinary Record, 79, 67-71.
  • Hoque M. (2002). An update on canine transmissible venereal tumor. Intas Polivet. 3(2), 227-234.
  • Kabuusu R., Stroup D., & Fernandez C. (2010). Risk factors and characteristics of canine transmissible venereal tumours in Grenada, West Indies. Veterinary and Comparative Oncology, 8, 50-55. 10.1111/j.1476-5829.2009.00204.x
  • Kennedy P.C., Cullen J.M., Edwards J.F., Goldschmidt M.H., Larsen S., Munson L. & Nielsen S. (1998). Tumors of the ovary. In: P.C. Kennedy (Ed), Histological classification of tumors of the genital system of domestic animals. (2nd ed), (pp 24-28), Vol IV. Armed ForcesInstitute of Pathology, Washington.
  • Klein M.K. (1996). Tumors of the female reproductivesystem. In: S.J.Withrow and E.G. MacEwen (Eds). Small Animal Clinical Oncology (2nd ed) (pp 347-355). W.B. Saunders, Philadelphia.
  • Milo J., & Snead E. (2014). A case of ocular canine transmissible venereal tumor. The Canadian Veterinary Journal, 55(1), 1245-1249.
  • Maclachlan N.J., & Kennedy P.C. (2008). Tumors of the genital systems. In: D.J. Meuten (Ed), Tumors in Domestic Animals (4th ed). (pp. 547-573). Blackwell.
  • Martins MIM., Souza F.F., & Gobello C. (2005). The canine transmissible venereal tumor: etiology, pathology, diagnosis and treatment. In: P.W. Concannon, G. England, J. Verstegen, C. Linde Forsberg (Eds), Recent Advances in Small Animal Reproduction (2nd ed). (pp. 161-167). International Veterinary Information Service.
  • Murchison E.P. (2008). Clonally transmissible cancers in dogs and Tasmanian devils. Oncogene, 27(2), 19-30. 10.1038/onc.2009.350
  • Murgia C., Pritchard J.K., Kim S.Y., Fassati A., & Weiss R.A. (2006). Clonal origin and evolution of a transmissible cancer. Cell Cycle, 126(3), 377-487. 10.1016/j.cell.2006.05.051
  • Ramaswamy S., Ross K.N., Lander E.S., & Golub T.R. (2003). A molecular signature of metastasis in primary solid tumors. Nature Genetics, 33, 49-54. 10.1038/ng1060
  • Robbins M. (2003). Reproductive oncology. In: D. Slatter (Ed). Textbook of Small Animal Surgery (3rd ed). (pp. 2437-2444). Saunders Elsevier.
  • Savadkoohi H.S., Dehghani S., Namazi F., Khafi M.A., & Jalali Y. (2013). Electrosurgical excision of a large uniform transmissible venereal tumor (TVT) in a spayed bitch: a case report. Journal of Animal and Poultry Sciences, 2(2), 60-64.
  • Smith C.A. (2003). Ovarian disorders of the bitch and queen. In: M.R.V. Kustritz (Ed), Small Animal Theriogenology (1st ed). (pp. 331-365) Saunders Elsevier.
  • Sontaş H., Altun D., Yılmaz Ö., Arun S., Şenünver A., & Eki̇ci̇ H. (2010). Concomitant occurrence of ovarian remnant syndrome, transmissible venereal tumor and stump pyometra in a bitch. Kafkas Universitesi Veteriner Fakultesi Dergisi, 16(4), 675-680. 10.9775/kvfd.2009.1185
  • Temitope A.A., Adetola A.R., Folashade M.A., Olutayo O.T., Edem A.R., Olubukola N.H. & Babajide K.O. (2010). Radiographic assessment of canine transmissible venereal tumor metastases. Communications in Theriogenology, 4(1), 1.
  • Özyurtlu N., Bademkıran S., Ünver Ö., Yıldız F. & İçen H. (2008). Dişi bir köpekte transmissible venereal tümörün abdominal ve subkutan inguinal bölgeye metastazı. Dicle Üniversitesi Veteriner Fakültesi Dergisi, 1(2), 48-51.
  • Uçmak Z.G., 1, Kırşan İ., Uçmak M., Erdoğan Bamaç Ö. & Gürel A. (2019). Clinical approaches for genital and extragenital metastasis of transmissible venereal tumor in a bitch with ovarian remnant syndrome Ankara Üniversitesi Veteriner Fakültesi Dergisi, 66, 417-421. 10.33988/auvfd.568858
  • Veer L.J., Dai H., Vijver M.J., He Y.D., Hart A.A., Mao M., Peterse H.L., Kooy K., Marton M.J., Kitteveen A.T., Schreiber G.J., Kerkhoven R.M., Roberts C., Linsley P.S., Bernards R., & Friend S.H. (2002). Gene expression profiling predicts clinical outcome of breast cancer. Nature, 415, 530-535. 10.1038/415530a
There are 33 citations in total.

Details

Primary Language English
Subjects Veterinary Sciences
Journal Section Case Report
Authors

Firdevs Binli 0000-0001-9547-8776

Serhan Ay 0000-0003-2116-5149

Gülşah Saral This is me 0000-0002-5584-3991

Sebati Sinan Ürkmez 0000-0002-8821-1835

Efe Karaca 0000-0003-4109-6013

Ishtiaq Ahmed This is me 0000-0003-3800-0869

Murat Fındık 0000-0003-1408-2548

Publication Date June 11, 2021
Submission Date February 11, 2021
Published in Issue Year 2021 Volume: 10 Issue: 1

Cite

APA Binli, F., Ay, S., Saral, G., Ürkmez, S. S., et al. (2021). Ovarian Metastatic Transmissible Venereal Tumour in a Dog – a case report and review. Animal Health Production and Hygiene, 10(1), 27-32.
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