Template Synthesis, Characterization, Antioxidant Effects, DNA Cleavage and Antimicrobial Studies of ZnII, NiII, MnII, CuII and CoII Complexes Containing Pyridazinone Moiety

Year 2020, , 40 - 54, 25.06.2020

Mehmet Sönmez , Özlem Bakırcı Hatice Gamze Soğukömeroğulları Sadin Özdemir , Mustafa Serkan Yalçın

https://doi.org/10.37094/adyujsci.589071

Abstract

In this study, novel
five Schiff base metal complexes derived from Zn^II, Ni^II,
Mn^II, Cu^II and Co^II metal salts and 5-benzoyl-4-hydroxy-2-methyl-6-phenyl-2H-pyridazine-3-one
with o-aminophenol have been
synthesized using a template method. Metal complexes were characterized by elemental analysis, FT-IR, UV-Vis, Mass and magnetic susceptibility.  Antioxidant effects, DNA cleavage, and antimicrobial studies of synthesized compounds were performed. DPPH scavenging and metal chelating activity was found to increase with concentration. The highest DPPH activity and ferrous ion chelating activity were obtained from compound Zn. DNA cleavage studies indicated that all tested compounds were cleavage active at the concentration of 100 mg/L. While all the synthesized compounds displayed antibacterial activity against E. hirae in order of Mn>Zn=Ni=Co>Cu. The compound Ni only showed antimicrobial activity against all microorganisms tested, especially against L. pneumophila subsp. pneumophila with inhibition zone value equal to 13 mm.

Keywords

Template synthesis, Schiff base complex, Antioxidant activity, DNA cleavage, Antimicrobial activity

Supporting Institution

Gaziantep University

Thanks

This study received no support from the fund.

Piridazinon Yapısı İçeren ZnII, NiII, MnII, CuII ve CoII Komplekslerinin Şablon Sentezleri, Karakterizasyonları, Antioksidan Etkileri, DNA Klevajı ve Antimikrobiyal Etkilerinin Araştırılması

Abstract

Bu çalışmada template metodu ile o-aminofenol, 5-benzoil-4-hidroksi-2-metil-6-fenil-2Hpiridazin-3-on ve ZnII, NiII, MnII, CuII ve CoII metal tuzlarından türeyen beş yeni Schiff baz kompleksi sentezlenmiştir. Metal kompleksler elemental analiz, FT-IR, UV-Vis, kütle ve manyetik duyarlılık ile karakterize edilmiştir. Sentezlenen bileşiklerin antioksidan etkileri, DNA bölünmesi ve antimikrobiyal çalışmaları yapılmıştır. DPPH süpürme ve metal şelatlama aktivitesinin konsantrasyona bağlı olarak arttığı bulunmuştur. En yüksek DPPH aktivitesi ve demir iyon şelatlama aktivitesi Zn bileşiğinden elde edildi. Sentezlenen tüm bileşikler, Mn>Zn=Ni=Co>Cu sırasına gore E. hirae’ye karşı antibakteriyal aktivite sergilerken, sadece Ni bileşiği test edilen tüm organizmalara karşı, özellikle de L. pneumophila subsp. pneumophila’ya 13 mm’ye eşit inhibisyon zon değerinde antimikrobiyal aktivite göstermiştir.

Keywords

Template sentez, Schiff baz kompleks, Antioksidan aktivite, DNA bölünmesi, Antimikrobiyal aktivite

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