Trigliserit/Glikoz İndeksi (TyG) ve Trigliserit/HDL-Kolesterol Oranı (TG/HDL-c) Gestasyonel Diyabeti Tahmin Edebilir mi?

Year 2023, , 117 - 120, 30.09.2023

Seval Yılmaz Ergani , Tolgay Tuyan İlhan , Betül Tokgöz , Burak Bayraktar , Mevlüt Bucak , Müjde Can İbanoğlu , Kadriye Yakut Yücel , Kadriye Erdoğan , Cantekin İskender , Yaprak Üstün

https://doi.org/10.20492/aeahtd.1327956

Abstract

AMAÇ: Birinci trimesterde trigliserit/glukoz indeksi (TyG) ve trigliserid/HDL-kolesterol oranı (TG /HDL-c) ölçümünün gestasyonel diyabetes mellitusu (GDM) tahmin edip edemeyeceğini araştırdık.
GEREÇ VE YÖNTEM: Gebelikte GDM'li 25 hasta ve glisemik kontrolü normal olan GDM'siz 52 hasta kontrol grubu olarak çalışmaya alındı. GDM tanısına hem insülin kontrollü diyabet hem de diyet kontrollü diyabet dahil edildi. İlk trimesterde ölçülen TG, HDL-c, TyG indeksi ve TG /HDL-c'yi içeren açlık glukoz ve plazma lipid profilleri analiz edildi.
BULGULAR: Trigliserit değerleri (ortalama gestasyonel diabetes grubunda 133±40 mg/dL, kontrol grubunda 100±54 mg/dL), TyG indeksi (ortalama gestasyonel diabetes grubunda 15,0±8,9, kontrol grubunda 8,8±5,0) ve TG/HDL-K oranı (ortalama gestasyonel diabetes grubunda 3,3±2,6 kontrol grubunda 1,9±2,6) GDM grubunda anlamlı olarak daha yüksek bulundu(sırasıyla p=0.01, p=0.01, p=0.01) GDM'yi öngörmek için TyG indeksi için optimal kesme değeri 10,4, duyarlılık %76, özgüllük %77 ve ROC analizinde eğri altında kalan alan (AUC) 0,765 idi (p < 0,001). GDM'yi öngörmek için TG/HDL-K oranı için optimal kesme değeri 2,3, duyarlılık %76, özgüllük 69, AUC 0,697 idi (p=0,005).
SONUÇ: İlk trimesterde ölçülen TyG ve TG/HDL-C oranının GDM'yi açlık plazma glukozundan daha iyi öngördüğü düşünülmektedir.

Keywords

Gestasyonel diabetes mellitus, birinci trimester, gebelik, Trigliserit/Glikoz İndeksi, Trigliserit/HDL-Kolesterol Oranı

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Can Triglyceride/Glucose Index (TyG) and Triglyceride/HDL-Cholesterol Ratio (TG/HDL-c) Predict Gestational Diabetes Mellitus?

Abstract

AIM: We investigated whether measurement of triglyceride/glucose index (TyG) and triglyceride/HDL-cholesterol ratio (TG /HDL-c) in the first trimester can predict gestational diabetes mellitus (GDM).
MATERIAL AND METHOD: Twenty-five patients with GDM and 52 women without GDM with normal glycemic control during pregnancy were included in the study as a control group. Both insulin-controlled diabetes and diet-controlled diabetes were included in the diagnosis of GDM. Fasting glucose and plasma lipid profiles including TG, HDL-c, TyG index, and TG /HDL-c measured in the first trimester were analyzed.
RESULTS: Triglyceride values (mean 133±40 mg/dL in the gestational diabetes group, 100±54 mg/dL in the control group), TyG index (15.0±8.9 in the mean gestational diabetes group, 8.8±5.0 in the control group), and TG/HDL-C ratio (mean 3.3±2.6 in the gestational diabetes group and 1.9±2.6 in the control group) was found to be significantly higher in the GDM group (p=0.01, p=0.01, p=0.01, respectively). The optimal cutoff value for TyG index was 10.4, sensitivity was 76%, specificity was 77%, and area under the receiver characteristic curve (AUC) was 0.765 to predict GDM (p < 0.001). The optimal cutoff value for the TG /HDL-C ratio was 2.3, sensitivity was 76%, specificity was 69, AUC 0.697 to predict GDM (p=0.005).
CONCLUSION: TyG and TG/HDL-C ratio measured in the first trimester are thought to predict GDM better than fasting plasma glucose.

Keywords

Gestational diabetes mellitus, first trimester, pregnancy, Triglyceride/Glucose Index, Triglyceride/HDL-Cholesterol Ratio

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