Correlation Between Vitamin D and Ferritin, Vitamin B12, Homocysteine, and Methylmalonic acid

Abstract

Aim: It is not well-known whether there is an association between vitamin D and other vitamin levels. In this study, potential interrelation between vitamin D and folate, ferritin, vitamin B12, homocysteine, and methylmalonic acid levels was examined. Material and Methods: Laboratory results of 189 adult patients (18-65 years old) who admitted to our Internal Medicine outpatient clinic between November 2022 to April 2023 were retrospectively retrieved from hospital registry. Participants younger than 18 and older than 65 years old, with a history of vitamin D replacement within 3 months, diagnosed with cancer, acute infection, pregnancy, renal or hepatic disease, malabsorption like Celiac or inflammatory bowel disease were excluded. Results: There was a positive correlation between vitamin D and both hemoglobin and ferritin (r=0.219 p=0.003 and r=0.262 p<0.001 respectively). Patients in the higher vitamin D quartiles had higher hemoglobin and ferritin levels compared to lesser quartiles. Vitamin D and MMA were found to be associated (OR= 4.576 %95 CI=1.506-13.903 p=0.007). There were no association between vitamin D and homocysteine, folate, and vitamin B12 levels respectively. Conclusion: We assume serum MMA is a more sensitive method than serum B12 measurement to show tissue level B12 deficiency and that is why vitamin B12, and vitamin D were not found to be associated with each other.

Keywords

• Ferritin
• homocysteine
• methylmalonic acid
• vitamin B12
• vitamin D

D vitamini ile Vitamin B12, Metilmalonik Asit, Homosistein ve Ferritin Düzeyleri Arasındaki İlişki

Abstract

Amaç: D vitamini ile diğer vitamin düzeyleri arasında bir ilişki olup olmadığı tam olarak bilinmemektedir. Bu çalışmada D vitamini ile folat, ferritin, B12 vitamini, homosistein ve metilmalonik asit (MMA) düzeyleri arasındaki potansiyel ilişki incelenmiştir. Gereç ve Yöntemler: Kasım 2022 ile Nisan 2023 tarihleri arasında Dahiliye polikliniğimize başvuran 189 yetişkin hastanın (18-65 yaş) laboratuvar sonuçları hastane kayıtlarından retrospektif olarak elde edildi. 18 yaş altı ve 65 yaş üstü, son 3 ay içinde D vitamini replasman öyküsü olan, kanser, akut enfeksiyon, gebelik, böbrek veya karaciğer hastalığı, Çölyak hastalığı gibi malabsorbsiyon veya inflamatuar barsak hastalığı tanısı alan katılımcılar çalışma dışı bırakıldı. Bulgular: D vitamini ile hemoglobin ve ferritin arasında pozitif korelasyon vardı (sırasıyla r=0,219 p=0,003 ve r=0,262 p<0,001). Daha yüksek D vitamini çeyrekliklerinde yer alan hastaların hemoglobin ve ferritin düzeyleri, daha düşük çeyreklik dilimlere kıyasla daha yüksekti. D vitamini ile MMA’nın ilişkili olduğu belirlendi (OR= 4,576 %95 GA=1,506-13,903 p=0,007). D vitamini ile sırasıyla homosistein, folat ve B12 vitamini düzeyleri arasında ilişki yoktu. Sonuç: Serum MMA’nın doku düzeyinde B12 eksikliğini göstermede serum B12 ölçümünden daha duyarlı bir yöntem olduğunu ve bu nedenle B12 vitamini ile D vitamininin birbiriyle ilişkili bulunmadığını düşünüyoruz.

Keywords

• Ferritin
• homosistein
• metilmalonik asit
• vitamin B12
• vitamin D

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