Helikobakter Pilori Eradikasyonun Serum Paraoksonaz Enzim Aktivitesine Etkisi

Year 2020, , 7 - 10, 30.06.2020

Muhammed Sacıkara , Oktay Bulur , Mehmet Polat , Yaşar Nazlıgul

https://doi.org/10.20492/aeahtd.672455

Abstract

Amaç: Helikobakter pilori (H. pilori) enfeksiyonu gastrointestinal ve ekstraintestinal hastalıklarla ilişkilidir. H. pilori bu hastalıklara spesifik virülans faktörleri yoluyla veya inflamasyon ve oksidasyonu arttırarak neden olur. HDL kolesterol ile ilişkili paraoksonaz-1 (PON-1) enzimi, HDL kolesterolün antioksidan ve antiaterojenik etkilerinden sorumludur. PON-1 seviyeleri bu nedenle kardiyovasküler hastalıklarla ilişkilidir. Bu çalışmada H. pilori eradikasyonu ve paraoksonaz aktivitesi arasındaki ilişkinin araştırılması amaçlanmıştır.
Gereç ve Yöntem: Çalışma H. pilori eradikasyon tedavisi almış ve eradikasyon tedavisi kontrol edilmiş 126 yetişkin hastada prospektif olarak yapıldı. H. pilori 38 hastada (17 erkek, 21 kadın) pozitif, 88 hastada (43 erkek, 45 kadın ) negatifdi.
Bulgular: H. pilori eradikasyon tedavisi sonrası paraoksonaz-1(PON-1) enzim seviyeleri; H. pilori negatif grupta 165,69 U/L ve H. pilori pozitif grupta 131,68 U/L olarak bulundu. Tedaviden sonra gruplar arasında paraoksonaz-1(PON-1) enzim seviyeleri açısından istatistiksel olarak anlamlı fark saptandı (p=0,02).
Sonuç: H. pilori eradikasyon tedavisi sonrası paraoksonaz-1 (PON-1) enzim seviyelerinde artış, LDL oksidasyonunda azalmaya ve buna sekonder antiaterosklerotik etkiye neden olmaktadır.

Keywords

Helikobakter pilori, , Paraoksonaz, , Ateroskleroz

The Effect of Helicobacter Pylori Eradication on Paraoxonase Enzyme Activity

Abstract

Purpose: Helicobacter pylori (H. pylori) infection is associated with gastrointestinal and extraintestinal diseases either directly via its special virulence factors or indirectly by increasing inflammation and oxidation. Paraoxonase-1 (PON–1) enzyme that is related to HDL cholesterol is responsible for the antioxidant and antiatherogenic effects of HDL cholesterol. PON–1 level is related to the risk of cardiovascular disease. We aimed to investigate the relation between H. pylori infection and PON-1 activity.
Material -Method: We prospectively evaluated 126 adult patients in a tertiary reference hospital in Ankara, Turkey. After H. pylori eradication therapy and checking for treatment success, 38 H. pylori-positive (17 male, 21 female) and 88 H. pylori-negative (43 male, 45 female ) patients were included in this study.
Results: PON–1 enzyme levels after H. pylori eradication therapy were 165,69U/L in H. pylori-negative and 131,68 U/L in H. pylori-positive groups. The difference in PON–1 enzyme levels after treatment in two groups was statistically significant (p=0,02).
Conclusion: Increased PON–1 enzyme levels after H. pylori eradication therapy might play a role in the antiatherosclerotic effect by reducing LDL oxidation.

Keywords

Helicobacter pylori, Paraoxonase, Atherosclerosis

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