IS SERUM FERRITIN LEVEL DIFFERENT BETWEEN HEALTHY INDIVIDUALS AND NEWLY DIAGNOSED PATIENTS WITH TYPE 2 DIABETES MELLITUS?: A CASE-CONTROL STUDY

Year 2021, , 102 - 106, 27.04.2021

Veli Sunar

https://doi.org/10.20492/aeahtd.826939

Abstract

Introduction: This study aims to evaluate whether serum ferritin levels differ between recently diagnosed patients with type 2 diabetes mellitus (DM) and healthy controls, and to assess the relationship between serum ferritin level, insulin resistance and metabolic control in patients with type 2 DM.
Material and methods: This study included 40 patients with recently diagnosed type 2 DM and 40 healthy controls. The Homeostasis Model Assessment of insulin resistance (HOMA-IR) score was used for evaluation of insulin resistance. HOMA-IR scores ≥2.7 were accepted as insulin resistance. The patient and control groups were compared in terms of age, gender, BMI, serum ferritin, insulin, HbA1c, and HOMA-IR scores. If ferritin levels correlated with other parameters was assessed in the patient group. Furthermore, patients with good (HbA1c<7%) and poor glycemic control (HbA1c≥7%) were compared regarding serum ferritin level.
Results: Ninety percent (n=36) of the patient group and 27.5% (n=11) of the controls had HOMA-IR scores ≥2.7. Serum ferritin levels were significantly higher in the patient group (153.57±150.01 vs 62.83±53.18; p=0.003). There were significant positive correlations between serum ferritin and fasting plasma glucose levels (r=0.419 p=0.007), HbA1c (r=0.410, p=0.009) and HOMA-IR score (r=0.320, p=0.044) in the patient group. Mean serum ferritin level of patients with poor metabolic control (201.20±170.67) was significantly higher than ones with good metabolic control (91.92±71.39) among patients with type 2 DM (p=0.047).
Conclusion: Serum ferritin levels were found to be higher in patients with type 2 DM than controls and there was positive correlation between serum ferritin levels and insulin resistance.

Keywords

ferritin, diabetes mellitus, insulin resistance

Supporting Institution

none

Project Number

none

Thanks

Dr İsmihan SUNAR for her precious support

SERUM FERRİTİN DÜZEYİ SAĞLIKLI BİREYLERLE YENİ TANI TİP 2 DİYABET HASTALARINDA FARKLI MIDIR?: VAKA KONTROL ÇALIŞMASI

Abstract

Giriş: Bu çalışmanın amacı yeni tanı tip 2 DM hastaları ile sağlıklı bireyler arasında serum ferritin düzeyi açısından fark olup olmadığını değerlendirmek, ayrıca tip 2 DM hastalarında serum ferritin düzeyinin insülin direnci ve metabolik kontrol ile ilişkisini araştırmaktır.
Materyal ve metod: Çalışmaya 40 yeni tanı tip 2 DM hastası ile 40 sağlıklı kişiden oluşan kontrol grubu dahil edildi. İnsülin direncini değerlendirmek için Homeostasis Model Assessment of insülin resistance (HOMA-IR) skoru kullanıldı. HOMA-IR skorunun ≥2,7 olması insulin direnci olarak kabul edildi. Hasta ve kontrol grubunu oluşturan bireyler yaş, cinsiyet dağılımı, VKİ, serum ferritin düzeyi, insülin düzeyi ve HOMA-IR skoru açısından karşılaştırıldı. Hasta grubundaki bireylerin ferritin düzeyi ile diğer parametreler arasındaki ilişki incelendi. Ayrica iyi metabolik kontrollü (HbA1c<%7) ve kötü metabolik kontrollü (HbA1c≥%7) hastaların serum ferritin düzeyleri karşılaştırıldı.
Bulgular: Hasta grubunun %90’ında (n=36), kontrol grubunun %27,5’inde (n=11) HOMA-IR skoru ≥2,7 olarak tespit edildi. Hasta grubunun ferritin düzeyi kontrol grubuna göre anlamlı olarak yüksek saptandı (153,57±150,01’e 62,83±53,18; p=0,003). Hasta grubunda ferritin düzeyi ile açlık kan şekeri (r=0.419 p=0.007), HbA1c (r=0.410, p=0.009) ve HOMA-IR skoru (r=0.320, p=0.044) arasında pozitif bir korelasyon tespit edildi. Tip 2 DM hastalarında kötü metabolik kontrollü hastaların ortalama ferritin düzeyleri (201,20±170,67) iyi metabolik kontrollü hastaların ortalama ferritin düzeylerine (91,92±71,39) göre anlamlı olarak daha yüksek saptandı (p=0,047).
Sonuç: Tip 2 DM hastalarında serum ferritin düzeyi sağlıklı bireylere göre yüksek saptanmış olup serum ferritin düzeyi ile insülin direnci arasında pozitif bir ilişki bulunmuştur.

Keywords

ferritin, diabetes mellitus, insülin dirsenci

Project Number

none

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