Türk Behçet hastalarının cinsiyet, HLA-B51 ve paterji testine göre klinik özelliklerinin değerlendirilmesi

Year 2019, Volume: 52 Issue: 3, 191 - 195, 21.12.2019

Nuh Ataş

Abstract

Purpose: The clinical features of Behçet
disease (BD) are variable between race and country. Gender, pathergy test and
HLA B51 also have impact on clinical manifestations of BD. The aim of this
study is to investigate clinical evaulation of Turkish patients with BD
according to gender, HLA B51 and pathergy test.

Material and Method: 97 Turkish patients (59
males, 38 females) fulfilling the International Study
Group criteria for Behçet Disease 
were evaulated retrospectively.

Results

The mean age was 36,2 ± 11,1 years. The median (IQR: interquartile range) age at
diagnosis, duration of disease and delay in diagnosis were 26 (14), 7 (8) and 4 (8) years. Oral
aphtous ulcers were the most common manifestation (100%), followed by genital
ulcers (%67), skin findings (54,6%), ocular (51,5%) and vascular involvement
(24,7%), arthritis (23,7%) and neurologic involvement (14,4%). HLA B51 and
Pathergy test were positive in 70,1% and 39,2% of patients, respectively.
Genital ulcer, skin findings and articular involvement and HLAB51 positivity
were similiar between male and female gender. Pathergy positivity, ocular and
vascular involvement were more common in men. Skin findings more rare in
pathergy positive group.

Conclusion : The clinical manifestations
of BD in Turkish patients were influenced by gender, rahter than pathergy and
HLA B51 positivity.

Key words:
Behçet Disease, HLA B51, pathergy test, gender

 

Amaç: Behçet
hastalığının (BH) klinik özellikleri ülkeye ve ırk’a göre farklılık
gösterebilmektedir. Cinsiyet, paterji testi ve HLA B51 de BH’nın klinik
özelliklerini etkileyebilmektedir. Bu çalışmanın amacı; cinsiyet, HLA B51 ve
paterji testinin Türk Behçet hastalarının kliniğine etkisini değerlendirmektir.

Gereç ve Yöntem:
International Study Group kriterlerine göre BH tanısı almış 97 Türk hasta
retrospektif olarak değerlendirildi.

Bulgular:
Ortalama yaş 36.2
± 11.1 yıl idi. Medyan (ÇAA:çeyreklerarası aralık) tanı yaşı, hastalık süresi
ve tanıda gecikme yaşı; 26 (14), 7 (8) and 4 (8) yıl idi. Oral aftöz ülserler
en sık gözlenen bulguydu(%100). Oral ülserleri, genital ülserler (%67), cilt
bulguları (%54,6), oküler (%51,5) ve vasküler tutulum (%24,7), artrit (%23,7) ve
nörolojik tutulum (%14,4) izlemekteydi. HLA B51 ve paterji testi, hastaların %
70,1’inde ve %39,2’sinde pozitifti. Genital ülser, cilt bulguları, artiküler
tutulum ve HLA B51 pozitifliği erkek ve kadın cinsiyette benzerdi. Paterji
pozitifliği, oküler ve vasküler tutulum erkeklerde daha fazlaydı. Paterji
pozitif olan grupta cilt bulguları daha nadirdi.

Sonuç: Türk
Behçet hastalarının klinik özellikleri cinsiyetten belirgin olarak
etkilenirken, paterji ve HLA B51 pozitifliğinden pek etkilenmemektedir.

Anahtar
kelimeler: Behçet hastalığı, HLA B51, paterji testi, cinsiyet

Keywords

Behçet hastalığı, HLA B51, paterji testi, cinsiyet

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