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COMPARISON OF THE HELICOBACTER PYLORI INFECTION WITH C14 UREA BREATH TEST AND DEMOGRAPHIC VARIABLES IN ELDERLY POPULATION

Year 2016, Volume: 49 Issue: 2, 94 - 99, 01.08.2016

Abstract

OBJECTIVE: The aim of this study was to investigate the prevalence of Helicobacter pylori Hp infection in elderly patients admitted for C14 urea breath test UBT and the relationship between Hp prevelance and epidemiologic, demographic variables.MATERIAL AND METHODS: The study included 296 elderly patients >65 years who were referred our nuclear medicine department to admit C14 UBT for Hp infection were included in the study. The patients were retrospectively evaluated and grouped according to the age, gender, blood group, past medical history, smoking and/or alcohol habit, presence of common systemic disease, body mass index, demographic properties like educational stage, presence of pet and evaluated the relationship of these properties with Hp positivity.RESULTS: Helicobacter pylori prevalence was 48.9 % in our elderly study population. The statistical significance was found in the evaluation of positivity of C14 UBT result p=0.04 . Positive correlation was found between the positive UBT and increasing age. Statistical significance wasn’t found between the positive Hp test and gender, ABO blood groups, smoking and/or alcohol habit, BMI value, presence of pet at home, any gastric complaints in family p>0.05 . There was statisticial significance between education level, presence of common systemic disease and positive test result p=0.001 .CONCLUSION: We found statistical significance between the Hp positivity and increeasing age, education level, presence of common systemic disease and no significance relationship among Hp prevalence and the other parameters in accordance with the literature

References

  • )Tünger Ö. Helicobacter Pylori infeksiyonları. Turkish Journal of Infection. 2008; 22: 107-15.
  • )Petrović M, Artiko V, Novosel S, et al. Relationship between Helicobacter pylori infection estimated by 14C-urea breath test and gender, blood groups and Rhesus factor. Hell J Nucl Med. ; 14: 21-4. )Uzunismail H. Türkiye’de Helicobacter Pylori Sorunu. Gastro- enterolojide Klinik Yaklaşım Sempozyum Dizisi. 2004; 38: 33-41.
  • )Liou JM, Lin JT, Lee YC, Wu CY, Wu MS. Helicobacter pylori infection in the elderly. Int J Gerontol. 2008; 2: 145-153.
  • )Bruce MG, Maaroos HI. Epidemiology of Helicobacter pylori infection. Helicobacter. 2008; 13: 1-6.
  • )Pilotto A, Di Mario F, Franceschi M. Treatment of Helicobacter pylori infection in elderly subjects. Age Ageing. 2000; 29: 103-9.
  • )Davidovic M, Svorcan P, Milanovic P, Antovic A, Milosevic D. Specifics of Helicobacter pylori infection/NSAID effects in the elderly. Rom J Gastroenterol. 2005; 14: 253-8.
  • )Naja F, Kreiger N, Sullivan T. Helicobacter pylori infection in Ontario: prevalence and risk factors. Can J Gastroenterol. 2007; : 501-6.
  • )Neri MC, Lai L, Bonetti P, Baldassarri AR, Monti M, De Luca P, Cunietti E, Quatrini M. Prevalence of Helicobacter pylori in- fection in elderly inpatients and in institutionalized old people: correlation with nutritional status. Age Ageing. 1996; 25: 17-21.
  • )Graham DY, Klein PD, Opekun AR. Boutton TW. Effect of age on the frequency of active Campylobacter pylori in- fection diagnosed by the (13 C)-urea breath test in normal subjects and patients with peptic ulcer disease. J Infect Dis. ; 157: 777-80. )Graham DY, Adam E, Reddy GT, et al. Seroepidemiology of Helicobacter pylori infection in India: comparison of developing and developed countries. Dig Dis Set. 1991; 36: 1084-8.
  • )The EUROGAST Study Group. An international association between Helicobacter pylori infection and gastric cancer: an in- ternational study. Lancet. 1993; 341: 1359-62.
  • )Lehours P, Yilmaz O. Epidemiology of Helicobacter pylori in- fection. Helicobacter. 2007; 12: 1-3.
  • )De Schryver A, Van Winckel M, Cornelis K, et al. Helicoba- cter pylori infection: further evidence for the role of feco-oral transmission. Helicobacter. 2006; 11: 523-8.
  • )Petrović M, Artiko V, Novosel S, et al. Relationship between Helicobacter pylori infection estimated by 14C-urea breath test and gender, blood groups and Rhesus factor. Hell J Nucl Med. ; 14: 21-4. )Kindermann A, Lopes AI. Helicobacter pylori infection in pe- diatrics. Helicobacter. 2009; 14: 52-7.
  • )Yang YJ, Sheu BS, Lee SC, et al. Children of Helicobacter pylo- ri-infected dyspeptic mothers are predisposed to H. pylori acqu- isition with subsequent iron deficiency and growth retardation. Helicobacter. 2005; 10: 249-55.
  • )Berkowicz I, Lee A. Person to person transmission of Campy- lobacter pylori. Lancet. 1987; 19: 680-1.
  • )Jones DM, Eldrige J, Whorwell PJ. Antibodies to Campyloba- cter pyloridis in household contact of infected patients. Br Med J. 1987; 294: 615.
  • )Lambert JR, Lin SK, Sievert W, Nicholson L, Schembri M, Guest C. High prevalence of Helicobacter pylori antibodies in an institutionalized population: evidence for person-to-person transmission. Am J Gastroenterol. 1995; 90: 2167-71.
  • )Huck-Joo TAN, Khean-Lee GOH. Extragastrointestinal ma- nifestations of Helicobacter pylori infection: Facts or myth? A critical review. J Digest Dis. 2012; 13: 342-9.
  • )Ogihara A, Kikuchi S, Hasegawa A, et al. Relationship betwe- en Helicobacter pylori infection and smoking and drinking ha- bits. J Gastroenterol Hepatol. 2000; 15: 271-6.
  • )Ciortescu I, Sfarti C, Stan M, Graur M, Stanciu C. [Prevalence of Helicobacter pylori infection in patients with diabetes melli- tus]. Rev Med Chir Soc Med Nat Iasi. 2009; 113: 1048-55.
  • )Roussos A, Philippou N, Gourgoulianis KI. Helicobacter py- lori infection and respiratory diseases: a review. World J Gastro- enterol. 2003; 9: 5-8.
  • )Sugimoto M, Yamaoka Y. Review of Helicobacter pylori in- fection and chronic renal failure. Ther Apher Dial. 2011; 15: 1-9.
  • )Hasni S, Ippolito A, Illei GG. Helicobacter pylori and autoim- mune diseases. Oral Dis. 2011; 17: 621-7.
  • )Jackson L, Britton J, Lewis SA, McKeever TM, Atherton J, Ful- lerton D, Fogarty AW. A population-based epidemiologic study of Helicobacter pylori infection and its association with systemic inflammation. Helicobacter. 2009; 14: 108-13.

YAŞLI POPULASYONUNDA C14 ÜRE NEFES TESTİ İLE HELİCOBACTER PYLORİ ENFEKSİYONU VE DEMOGRAFİK DEĞİŞKENLERİN KARŞILAŞTIRILMASI

Year 2016, Volume: 49 Issue: 2, 94 - 99, 01.08.2016

Abstract

AMAÇ: Bu çalışmanın amacı, C14 üre nefes testi ÜNT için başvuran yaşlı hastalarda Helikobakter pilori Hp enfeksiyonunun prevelansını ve Hp prevelansı ile epidemiyolojik, demografik değişkenler arasındaki ilişkiyi araştırmaktı. GEREÇ VE YÖNTEMLER: Çalışmaya nükleer tıp kliniğimize Hp enfeksiyonu için C14 ÜNT uygulanması amacıyla refere edilen 296 yaşlı hasta >65 yaş dahil edildi. Hastalar retrospektif olarak değerlendirildi ve yaş, cinsiyet, kan grubu, geçmiş medikal hikayesi, sigara ve/veya alkol alışkanlığı, yaygın sistemik hastalık bulunması, vücut kitle indeksi VKİ , eğitim seviyesi, evcil hayvan bulunması gibi demografik özelliklere göre gruplandı ve bunlarla Hp pozitifliği arasındaki ilişki değerlendirildi.BULGULAR: Helikobakter pilori prevelansı, bizim yaşlı hasta popülasyonumuzda % 48,9’du. C14 ÜNT sonuçlarının pozitifliğinin değerlendirmesinde istatistiksel anlamlılık bulundu p=0.04 . Pozitif ÜNT ile artan yaş arasında pozitif korelasyon bulundu. Pozitif Hp testi ile cinsiyet, ABO kan grupları, sigara ve/veya alkol alışkanlığı, VKİ değeri, evde evcil hayvan bulunması, ailede herhangi bir gastrik şikayet bulunması arasında istatistiksel anlamlılık saptanmadı p>0,05 . Pozitif test sonuçları ile eğitim seviyesi, yaygın sistemik hastalık bulunması arasında istatistiksel anlamlılık vardı p=0.001 .SONUÇ: Helikobakter pilori pozitifliği ile artan yaş, eğitim seviyesi, yaygın sistemik hastalık bulunması arasında istatistiksel anlamlılık bulduk ve literatürle uyumlu olarak Hp prevelansı ile diğer parametreler arasında anlamlı ilişki yoktu

References

  • )Tünger Ö. Helicobacter Pylori infeksiyonları. Turkish Journal of Infection. 2008; 22: 107-15.
  • )Petrović M, Artiko V, Novosel S, et al. Relationship between Helicobacter pylori infection estimated by 14C-urea breath test and gender, blood groups and Rhesus factor. Hell J Nucl Med. ; 14: 21-4. )Uzunismail H. Türkiye’de Helicobacter Pylori Sorunu. Gastro- enterolojide Klinik Yaklaşım Sempozyum Dizisi. 2004; 38: 33-41.
  • )Liou JM, Lin JT, Lee YC, Wu CY, Wu MS. Helicobacter pylori infection in the elderly. Int J Gerontol. 2008; 2: 145-153.
  • )Bruce MG, Maaroos HI. Epidemiology of Helicobacter pylori infection. Helicobacter. 2008; 13: 1-6.
  • )Pilotto A, Di Mario F, Franceschi M. Treatment of Helicobacter pylori infection in elderly subjects. Age Ageing. 2000; 29: 103-9.
  • )Davidovic M, Svorcan P, Milanovic P, Antovic A, Milosevic D. Specifics of Helicobacter pylori infection/NSAID effects in the elderly. Rom J Gastroenterol. 2005; 14: 253-8.
  • )Naja F, Kreiger N, Sullivan T. Helicobacter pylori infection in Ontario: prevalence and risk factors. Can J Gastroenterol. 2007; : 501-6.
  • )Neri MC, Lai L, Bonetti P, Baldassarri AR, Monti M, De Luca P, Cunietti E, Quatrini M. Prevalence of Helicobacter pylori in- fection in elderly inpatients and in institutionalized old people: correlation with nutritional status. Age Ageing. 1996; 25: 17-21.
  • )Graham DY, Klein PD, Opekun AR. Boutton TW. Effect of age on the frequency of active Campylobacter pylori in- fection diagnosed by the (13 C)-urea breath test in normal subjects and patients with peptic ulcer disease. J Infect Dis. ; 157: 777-80. )Graham DY, Adam E, Reddy GT, et al. Seroepidemiology of Helicobacter pylori infection in India: comparison of developing and developed countries. Dig Dis Set. 1991; 36: 1084-8.
  • )The EUROGAST Study Group. An international association between Helicobacter pylori infection and gastric cancer: an in- ternational study. Lancet. 1993; 341: 1359-62.
  • )Lehours P, Yilmaz O. Epidemiology of Helicobacter pylori in- fection. Helicobacter. 2007; 12: 1-3.
  • )De Schryver A, Van Winckel M, Cornelis K, et al. Helicoba- cter pylori infection: further evidence for the role of feco-oral transmission. Helicobacter. 2006; 11: 523-8.
  • )Petrović M, Artiko V, Novosel S, et al. Relationship between Helicobacter pylori infection estimated by 14C-urea breath test and gender, blood groups and Rhesus factor. Hell J Nucl Med. ; 14: 21-4. )Kindermann A, Lopes AI. Helicobacter pylori infection in pe- diatrics. Helicobacter. 2009; 14: 52-7.
  • )Yang YJ, Sheu BS, Lee SC, et al. Children of Helicobacter pylo- ri-infected dyspeptic mothers are predisposed to H. pylori acqu- isition with subsequent iron deficiency and growth retardation. Helicobacter. 2005; 10: 249-55.
  • )Berkowicz I, Lee A. Person to person transmission of Campy- lobacter pylori. Lancet. 1987; 19: 680-1.
  • )Jones DM, Eldrige J, Whorwell PJ. Antibodies to Campyloba- cter pyloridis in household contact of infected patients. Br Med J. 1987; 294: 615.
  • )Lambert JR, Lin SK, Sievert W, Nicholson L, Schembri M, Guest C. High prevalence of Helicobacter pylori antibodies in an institutionalized population: evidence for person-to-person transmission. Am J Gastroenterol. 1995; 90: 2167-71.
  • )Huck-Joo TAN, Khean-Lee GOH. Extragastrointestinal ma- nifestations of Helicobacter pylori infection: Facts or myth? A critical review. J Digest Dis. 2012; 13: 342-9.
  • )Ogihara A, Kikuchi S, Hasegawa A, et al. Relationship betwe- en Helicobacter pylori infection and smoking and drinking ha- bits. J Gastroenterol Hepatol. 2000; 15: 271-6.
  • )Ciortescu I, Sfarti C, Stan M, Graur M, Stanciu C. [Prevalence of Helicobacter pylori infection in patients with diabetes melli- tus]. Rev Med Chir Soc Med Nat Iasi. 2009; 113: 1048-55.
  • )Roussos A, Philippou N, Gourgoulianis KI. Helicobacter py- lori infection and respiratory diseases: a review. World J Gastro- enterol. 2003; 9: 5-8.
  • )Sugimoto M, Yamaoka Y. Review of Helicobacter pylori in- fection and chronic renal failure. Ther Apher Dial. 2011; 15: 1-9.
  • )Hasni S, Ippolito A, Illei GG. Helicobacter pylori and autoim- mune diseases. Oral Dis. 2011; 17: 621-7.
  • )Jackson L, Britton J, Lewis SA, McKeever TM, Atherton J, Ful- lerton D, Fogarty AW. A population-based epidemiologic study of Helicobacter pylori infection and its association with systemic inflammation. Helicobacter. 2009; 14: 108-13.
There are 24 citations in total.

Details

Primary Language Turkish
Journal Section Original Research Article
Authors

Murat Sadıç This is me

Hasan İkbal Atılgan This is me

Gökhan Koca This is me

Koray Demirel This is me

Aylin Baskın This is me

Nur Aydınbelge This is me

Meliha Korkmaz This is me

Publication Date August 1, 2016
Published in Issue Year 2016 Volume: 49 Issue: 2

Cite

AMA Sadıç M, Atılgan Hİ, Koca G, Demirel K, Baskın A, Aydınbelge N, Korkmaz M. YAŞLI POPULASYONUNDA C14 ÜRE NEFES TESTİ İLE HELİCOBACTER PYLORİ ENFEKSİYONU VE DEMOGRAFİK DEĞİŞKENLERİN KARŞILAŞTIRILMASI. Ankara Eğitim ve Araştırma Hastanesi Tıp Dergisi. August 2016;49(2):94-99.