Research Article
Herpes Zoster Tanısıyla Takip Edilen Hastaların Demografik, Klinik ve Laboratuvar Özelliklerinin Değerlendirilmesi
Abstract
AMAÇ: Herpes zoster (HZ), varisella zoster virüsünün reaktivasyonu sonucu meydana gelir. Öncelikle yaşlılarda ve bağışıklık sistemi baskılanmış kişilerde sık görülür. Zoster aşısının kullanılmaya başlamasının ardından HZ sıklık ve komplikasyonlarında azalma izlenmekle birlikte HZ, gelişmekte olan ülkeler için halen sorun teşkil etmektedir. Bu çalışmanın amacı HZ tanısıyla takip edilen hastaların demografik özellikleri, hastalıkla ilişkili klinik özellikleri ve laboratuvar bulgularını değerlendirmektir.
GEREÇ VE YÖNTEM: Mayıs 2014- Mayıs 2018 tarihleri arasında dermatoloji kliniğine HZ tanısıyla başvuran hastalar ICD 10 kodları (B02, B02.3, B02.8, B02.9) taranarak belirlendi. Üç bin sekiz yüz elli altı hastanın elektronik dosya kayıtları geriye dönüşlü olarak incelendi ve hastalık özellikleri kaydedildi.
BULGULAR: Hastaların %47,6’sı kadın %52,4’ü erkekti. Ortalama yaş 50,89 (±18.3) olarak hesaplandı. HZ insidansında mevsimlere göre farklılık izlenmedi (ilkbahar: %27,1; yaz: %22,9; sonbahar: %25,6; kış: %24,4). Ancak, hospitalizasyon ve oküler komplikasyon sıklığında sırasıyla ilkbahar (ilkbahar: %36; yaz: %23; sonbahar: %25; kış: %16) ve sonbahar (ilkbahar: %23,1; yaz: %7,7; sonbahar: %53,8; kış: %15,4) aylarında artış görüldü. Oftalmik tutulum hospitalize edilen hastaların %13’ünde izlendi ve yapılan lojistik regresyon analizi yaş, mevsim ve kan platelet dağılım genişliği (PDW) düzeylerinin oküler komplikasyon riski ile ilişkili olduğunu gösterdi. Sonbahar mevsiminde başvuran hastalar diğer mevsimler ile karşılaştırıldığında oftalmik tutulum için artmış riske sahiplerdi. Mevsime ek olarak PDW düzeylerindeki her bir birimlik azalma ve yaştaki her bir yıllık artış oküler komplikasyon riskini 1,29 (%95 GA: 1,01-1,69; p=0,048) ve 1,08 (%95 GA: 1,009-1,156; p=0,026) kat arttırmaktaydı.
SONUÇ: HZ epidemiyolojisi ve oftalmik tutulum için risk faktörlerinin belirlenmesi hasta yönetiminde klinisyene yardımcı olabilir.
Supporting Institution
Yok
Project Number
Yok
References
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N Engl J Med. 2014;371(16):1526-33. 8. Koshy E, Mengting L, Kumar H, Jianbo W. Epidemiology, treatment and prevention of herpes zoster: A comprehensive review. Indian J Dermatol Venereol Leprol. 2018;84(3):251-62. 9. Johnson RW, Alvarez-Pasquin MJ, Bijl M, et al. Herpes zoster epidemiology, management, and disease and economic burden in Europe: a multidisciplinary perspective. Ther Adv Vaccines. 2015;3(4):109-20. 10. Goh CL, Khoo L. A retrospective study of the clinical presentation and outcome of herpes zoster in a tertiary dermatology outpatient referral clinic. Int J Dermatol. 1997;36(9):667-72. 11. Chidiac C, Bruxelle J, Daures JP, et al. Characteristics of patients with herpes zoster on presentation to practitioners in France. Clin Infect Dis. 2001;33(1):62-9. 12. Kim YJ, Lee CN, Lim CY, Jeon WS, Park YM. Population-based study of the epidemiology of herpes zoster in Korea. J Korean Med Sci. 2014;29(12):1706-10. 13. Thomas SL, Hall AJ. What does epidemiology tell us about risk factors for herpes zoster? Lancet Infect Dis. 2004;4(1):26-33. 14. Kawai K, Gebremeskel BG, Acosta CJ. Systematic review of incidence and complications of herpes zoster: towards a global perspective. BMJ Open. 2014;4(6):e004833. 15. Vukmanovic-Stejic M, Sandhu D, Seidel JA, et al. The Characterization of Varicella Zoster Virus-Specific T Cells in Skin and Blood during Aging. J Invest Dermatol. 2015;135(7):1752-62. 16. Garcia-Rojas A, Gil-Prieto R, Nunez-Gallo DA, Matute-Cruz P, Gil-de-Miguel A. Hospitalizations realted to herpes zoster infection in the Canary Islands, Spain (2005-2014). BMC Infect Dis. 2017;17(1):586. 17. Lu WH, Lin CW, Wang CY, Chen LK, Hsiao FY. Epidemiology and long-term disease burden of herpes zoster and postherpetic neuralgia in Taiwan: a population-based, propensity score-matched cohort study. BMC Public Health. 2018;18(1):369. 18. Wu PY, Wu HD, Chou TC, Sung FC. Varicella vaccination alters the chronological trends of herpes zoster and varicella. PLoS One. 2013;8(10):e77709. 19. Acer E, Kaya Erdogan H, Bulur I, Acar EM. Evaluation of demographic and clinical characteristics of 166 patients with herpes zoster in the Kırşehir region. TURKDERM. 2018; 52(3): 95-99. 20. Hong MJ, Kim YD, Cheong YK, Park SJ, Choi SW, Hong HJ. Epidemiology of Postherpetic Neuralgia in Korea: An Electronic Population Health Insurance System Based Study. Medicine (Baltimore). 2016;95(14):e3304. 21. Weber MW, Mulholland EK, Greenwood BM. Respiratory syncytial virus infection in tropical and developing countries. Trop Med Int Health. 1998;3(4):268-80. 22. Bloom-Feshbach K, Alonso WJ, Charu V, et al. Latitudinal variations in seasonal activity of influenza and respiratory syncytial virus (RSV): a global comparative review. PLoS One. 2013;8(2):e54445. 23. Brewster DR, Greenwood BM. Seasonal variation of paediatric diseases in The Gambia, west Africa. Ann Trop Paediatr. 1993;13(2):133-46. 24. Grassly NC, Fraser C. Seasonal infectious disease epidemiology. Proc Biol Sci. 2006;273(1600):2541-50. 25. Paynter S, Ware RS, Sly PD, Williams G, Weinstein P. Seasonal immune modulation in humans: observed patterns and potential environmental drivers. J Infect. 2015;70(1):1-10. 26. Dopico XC, Evangelou M, Ferreira RC, et al. Widespread seasonal gene expression reveals annual differences in human immunity and physiology. Nat Commun. 2015;6:7000. 27. O'Connor KM, Paauw DS. Herpes zoster. Med Clin North Am. 2013;97(4):503-22, ix. 28. Drolet M, Brisson M, Schmader K, et al. Predictors of postherpetic neuralgia among patients with herpes zoster: a prospective study. J Pain. 2010;11(11):1211-21. 29. Puri LR, Shrestha GB, Shah DN, Chaudhary M, Thakur A. Ocular manifestations in herpes zoster ophthalmicus. Nepal J Ophthalmol. 2011;3(2):165-71. 30. Nithyanandam S, Dabir S, Stephen J, Joseph M. Eruption severity and characteristics in herpes zoster ophthalmicus: correlation with visual outcome, ocular complications, and postherpetic neuralgia. Int J Dermatol. 2009;48(5):484-7. 31. Borkar DS, Tham VM, Esterberg E, et al. Incidence of herpes zoster ophthalmicus: results from the Pacific Ocular Inflammation Study. Ophthalmology. 2013;120(3):451-6. 32. Yamada K, Hayasaka S, Yamamoto Y, Setogawa T. Cutaneous eruption with or without ocular complications in patients with herpes zoster involving the trigeminal nerve. Graefes Arch Clin Exp Ophthalmol. 1990;228(1):1-4. 33. Vagdatli E, Gounari E, Lazaridou E, Katsibourlia E, Tsikopoulou F, Labrianou I. Platelet distribution width: a simple, practical and specific marker of activation of coagulation. Hippokratia. 2010;14(1):28-32. 34. Seyoum M, Enawgaw B, Melku M. Human blood platelets and viruses: defense mechanism and role in the removal of viral pathogens. Thromb J. 2018;16:16.
Year 2020,
Volume: 53 Issue: Ek Sayı 1, 33 - 40, 30.06.2020
Abstract
Project Number
Yok
References
- 1. Johnson RW. Herpes zoster and postherpetic neuralgia. Expert Rev Vaccines. 2010;9(3 Suppl):21-6. 2. Yawn BP, Gilden D. The global epidemiology of herpes zoster. Neurology. 2013;81(10):928-30. 3. Pinchinat S, Cebrian-Cuenca AM, Bricout H, Johnson RW. Similar herpes zoster incidence across Europe: results from a systematic literature review. BMC Infect Dis. 2013;13:170. 4. Tanuseputro P, Zagorski B, Chan KJ, Kwong JC. Population-based incidence of herpes zoster after introduction of a publicly funded varicella vaccination program. Vaccine. 2011;29(47):8580-4. 5. Chen N, Li Q, Yang J, Zhou M, Zhou D, He L. Antiviral treatment for preventing postherpetic neuralgia. Cochrane Database Syst Rev. 2014(2):CD006866. 6. Studahl M, Petzold M, Cassel T. Disease burden of herpes zoster in Sweden--predominance in the elderly and in women - a register based study. BMC Infect Dis. 2013;13:586. 7. Johnson RW, Rice AS. Clinical practice. Postherpetic neuralgia. N Engl J Med. 2014;371(16):1526-33. 8. Koshy E, Mengting L, Kumar H, Jianbo W. Epidemiology, treatment and prevention of herpes zoster: A comprehensive review. Indian J Dermatol Venereol Leprol. 2018;84(3):251-62. 9. Johnson RW, Alvarez-Pasquin MJ, Bijl M, et al. Herpes zoster epidemiology, management, and disease and economic burden in Europe: a multidisciplinary perspective. Ther Adv Vaccines. 2015;3(4):109-20. 10. Goh CL, Khoo L. A retrospective study of the clinical presentation and outcome of herpes zoster in a tertiary dermatology outpatient referral clinic. Int J Dermatol. 1997;36(9):667-72. 11. Chidiac C, Bruxelle J, Daures JP, et al. Characteristics of patients with herpes zoster on presentation to practitioners in France. Clin Infect Dis. 2001;33(1):62-9. 12. Kim YJ, Lee CN, Lim CY, Jeon WS, Park YM. Population-based study of the epidemiology of herpes zoster in Korea. J Korean Med Sci. 2014;29(12):1706-10. 13. Thomas SL, Hall AJ. What does epidemiology tell us about risk factors for herpes zoster? Lancet Infect Dis. 2004;4(1):26-33. 14. Kawai K, Gebremeskel BG, Acosta CJ. Systematic review of incidence and complications of herpes zoster: towards a global perspective. BMJ Open. 2014;4(6):e004833. 15. Vukmanovic-Stejic M, Sandhu D, Seidel JA, et al. The Characterization of Varicella Zoster Virus-Specific T Cells in Skin and Blood during Aging. J Invest Dermatol. 2015;135(7):1752-62. 16. Garcia-Rojas A, Gil-Prieto R, Nunez-Gallo DA, Matute-Cruz P, Gil-de-Miguel A. Hospitalizations realted to herpes zoster infection in the Canary Islands, Spain (2005-2014). BMC Infect Dis. 2017;17(1):586. 17. Lu WH, Lin CW, Wang CY, Chen LK, Hsiao FY. Epidemiology and long-term disease burden of herpes zoster and postherpetic neuralgia in Taiwan: a population-based, propensity score-matched cohort study. BMC Public Health. 2018;18(1):369. 18. Wu PY, Wu HD, Chou TC, Sung FC. Varicella vaccination alters the chronological trends of herpes zoster and varicella. PLoS One. 2013;8(10):e77709. 19. Acer E, Kaya Erdogan H, Bulur I, Acar EM. Evaluation of demographic and clinical characteristics of 166 patients with herpes zoster in the Kırşehir region. TURKDERM. 2018; 52(3): 95-99. 20. Hong MJ, Kim YD, Cheong YK, Park SJ, Choi SW, Hong HJ. Epidemiology of Postherpetic Neuralgia in Korea: An Electronic Population Health Insurance System Based Study. Medicine (Baltimore). 2016;95(14):e3304. 21. Weber MW, Mulholland EK, Greenwood BM. Respiratory syncytial virus infection in tropical and developing countries. Trop Med Int Health. 1998;3(4):268-80. 22. Bloom-Feshbach K, Alonso WJ, Charu V, et al. Latitudinal variations in seasonal activity of influenza and respiratory syncytial virus (RSV): a global comparative review. PLoS One. 2013;8(2):e54445. 23. Brewster DR, Greenwood BM. Seasonal variation of paediatric diseases in The Gambia, west Africa. Ann Trop Paediatr. 1993;13(2):133-46. 24. Grassly NC, Fraser C. Seasonal infectious disease epidemiology. Proc Biol Sci. 2006;273(1600):2541-50. 25. Paynter S, Ware RS, Sly PD, Williams G, Weinstein P. Seasonal immune modulation in humans: observed patterns and potential environmental drivers. J Infect. 2015;70(1):1-10. 26. Dopico XC, Evangelou M, Ferreira RC, et al. Widespread seasonal gene expression reveals annual differences in human immunity and physiology. Nat Commun. 2015;6:7000. 27. O'Connor KM, Paauw DS. Herpes zoster. Med Clin North Am. 2013;97(4):503-22, ix. 28. Drolet M, Brisson M, Schmader K, et al. Predictors of postherpetic neuralgia among patients with herpes zoster: a prospective study. J Pain. 2010;11(11):1211-21. 29. Puri LR, Shrestha GB, Shah DN, Chaudhary M, Thakur A. Ocular manifestations in herpes zoster ophthalmicus. Nepal J Ophthalmol. 2011;3(2):165-71. 30. Nithyanandam S, Dabir S, Stephen J, Joseph M. Eruption severity and characteristics in herpes zoster ophthalmicus: correlation with visual outcome, ocular complications, and postherpetic neuralgia. Int J Dermatol. 2009;48(5):484-7. 31. Borkar DS, Tham VM, Esterberg E, et al. Incidence of herpes zoster ophthalmicus: results from the Pacific Ocular Inflammation Study. Ophthalmology. 2013;120(3):451-6. 32. Yamada K, Hayasaka S, Yamamoto Y, Setogawa T. Cutaneous eruption with or without ocular complications in patients with herpes zoster involving the trigeminal nerve. Graefes Arch Clin Exp Ophthalmol. 1990;228(1):1-4. 33. Vagdatli E, Gounari E, Lazaridou E, Katsibourlia E, Tsikopoulou F, Labrianou I. Platelet distribution width: a simple, practical and specific marker of activation of coagulation. Hippokratia. 2010;14(1):28-32. 34. Seyoum M, Enawgaw B, Melku M. Human blood platelets and viruses: defense mechanism and role in the removal of viral pathogens. Thromb J. 2018;16:16.
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Details
| Primary Language | Turkish |
|---|---|
| Subjects | Health Care Administration |
| Journal Section | Original research article |
| Authors | |
| Project Number | Yok |
| Publication Date | June 30, 2020 |
| Submission Date | January 8, 2020 |
| Published in Issue | Year 2020 Volume: 53 Issue: Ek Sayı 1 |