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RELATIONSHIP BETWEEN ROUTINE INFLAMMATORY MARKERS AND EJECTION FRACTION IN ELDERLY MEN WITH STABLE CORONARY ARTERY DISEASE

Year 2020, Volume: 53 Issue: 3, 165 - 170, 31.12.2020
https://doi.org/10.20492/aeahtd.668894

Abstract

Purpose: New inflammatory markers have recently been proposed for chronic inflammatory diseases. Inflammation plays an important role in the pathogenesis of stable coronary artery disease(SCAD). The aim of our study was to evaluate hematological parameters in elderly male patients with SCAD.
Material and Methods: Between March 2015 and August 2019, 131 male patients over 65 years of age who had exertion angina for 3 months and had 3 vascular disease on coronary angiography and had an ejection fraction (EF) of less than 55% on transthoracic echocardiogram were included in the study group 1. A total of 117 male patients over 65 years of age who had exertion angina more than 3 months and 3-vessel disease on coronary angiography and whose EF was above 55% on transthoracic echocardiogram were included in the study. Data of elderly male patients were recorded from the patient files of the institution. The data of the two study groups were compared.
Results: In group 1, Red Cell Distribution Width (RDW), Mean Platelet Volume (MPV)/Platelet (P) and RDW/P values were significantly higher than group 2 (p <.01)
Conclusion: Routine inflammatory markers were higher in elderly men with stable coronary artery disease with low ejection fraction than in normal ejection fractioned.

Thanks

The authors report no conflict of interest.

References

  • 1. Lang RM1, Bierig M, Devereux RB, et al. Chamber Quantification Writing Group; American Society of Echocardiography’s Guidelines and Standards Committee; European Association of Echocardiography. Recommendations for chamber quantification: a report from the American Society of Echocardiography’s Guidelines and Standards Committee and the Chamber Quantification Writing Group, developed in conjunction with the European Association of Echocardiography, a branch of the European Society of Cardiology. J Am Soc Echocardiogr 2005;18:1440–1463. 2. Yancy CW, Jessup M, Bozkurt B, et al; American College of Cardiology Foundation. American Heart Association Task Force on Practice Guidelines 2013 ACCF/AHA guideline for the management of heart failure: A report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol 2013;62:e147–e239. 3. Packard RR, Libby P. Inflammation in atherosclerosis: from vascular biology to biomarker discovery and risk prediction. Clin Chem. 2008;54(1):24-38. 4. Kinlay S, Ganz P. Role of endothelial dysfunction in coronary artery disease and implications for therapy. Am J Cardiol. 1997; 80(9A):11I-16I. 5. Satilmis Bilgin, Gulali Aktas, M. Zahid Kocak, et al: Association between novel inflammatory markers derived from hemogram indices and metabolic parameters in type 2 diabetic men, The Aging Male, 2019; DOI: 10.1080/13685538.2019.1632283 6. Motomura T, Shirabe K, Mano Y, et al. Neutrophil lymphocyte ratio reflects hepatocellular carcinoma recurrence after liver transplantation via inflammatory microenvironment. J Hepatol. 2013;58:58–64. 7. Fu H, Qin B, Hu Z, et al. Neutrophil- and platelet-to lymphocyte ratios are correlated with disease activity in rheumatoid arthritis. Clin Lab. 2015;61:269–273. 8. Kocak MZ, Aktas G, Erkus E, et al. Mean platelet volume to lymphocyte ratio as a novel marker for diabetic nephropathy. J Coll Physicians Surg Pak. 2018; 28:844–847. 9. Gasparyan AY, Sandoo A, Stavropoulos-Kalinoglou A, et al. Mean platelet volume in patients with rheumatoid arthritis: the effect of anti-TNF-alpha therapy. Rheumatol Int. 2010;30:1125–1129. 10. Dagistan Y, Dagistan E, Gezici AR, et al. Could red cell distribution width and mean platelet volume be a predictor for lumbar disc hernias? Ideggyogy Szemle. 2016;69:411–414. 11. Aktas G, Sit M, Karagoz I, et al. Could red cell distribution width be marker of thyroid cancer? J Coll Physicians Surg Pak. 2017;27:556–558. 12. Osman Sönmez, Gökhan Erta§, Ahmet Bacaksizet al. Relation of neutrophil -to- lymphocyte ratio with the presence and complexity of coronary artery disease: an observational study. Anadolu Kardiyol Derg. 2013 Nov;13(7):662-7. 13. Lloyd-Jones DM, Larson MG, Leip EP, et al; Framingham Heart Study. Lifetime risk for developing congestive heart failure: the Framingham Heart Study. Circulation 2002;106:3068– 3072. 14. Alderman EL, Bourassa MG, Cohen LS, et al Ten-year follow-up of survival and myocardial infarction in the randomized Coronary Artery Surgery Study. Circulation 1990;82:1629–1646. 15. Simonsen JA, Johansen A, Gerke O, et al. Outcome with invasive versus medical treatment of stable coronary artery disease: influence of perfusion defect size, ischemia, and ejection fraction. EuroIntervention. 2016;11(10):1118-24. 16. Libby R Ridker PM, Maseri A. Inflammation and atherosclerosis. Circulation 2002; 105:1135-43. 17. Packard RR, Libby P. Inflammation in atherosclerosis: from vascular biology to biomarker discovery and risk prediction. Clin Chem. 2008;54(1):24-38). 18. Kinlay S, Ganz P. Role of endothelial dysfunction in coronary artery disease and implications for therapy. Am J Cardiol. 1997; 80(9A):11I-16I. 19. Chen H, Ding X, Li J, et al. White blood cell count: an independent predictor of coronary heart disease risk in middle-aged and elderly population with hyperuricemia. Medicine (Baltimore). 2018 Dec;97(51):e13729. 20. Orakzai SH1, Orakzai RH, Nasir K, Carvalho JA, Blumenthal RS, Santos RD. Relationship between white blood cell count and Framingham Risk Score in asymptomatic men. Arch Med Res. 2007 May;38(4):386-91. 21. Gillum RF, Mussolino ME, Madans JH. Counts of neutrophils, lymphocytes, and monocytes, cause-specific mortality and coronary heart disease: the NHANES-I epidemiologic follow-up study. Ann Epidemiol. 2005 Apr;15(4):266-71. 22. Sansanayudh N, Anothaisintawee T, Muntham D, et al, Thakkinstian A. Mean platelet volume and coronary artery disease: a systematic review and meta-analysis. Int J Cardiol. 2014 Aug 20;175(3):433-40. 23. Wada H, Dohi T, Miyauchi K, et al. Mean platelet volume and long-term cardiovascular outcomes in patients with stable coronary artery disease. Atherosclerosis. 2018 Oct;277:108-112. 24. Sincer I, Gunes Y, Mansiroglu AK, et al. Association of mean platelet volume and red blood cell distribution width with coronary collateral development in stable coronary artery disease. Postepy Kardiol Interwencyjnej. 2018;14(3):263-269. 25. Sönmez O, Ertaş G, Bacaksız Aet al. Relation of neutrophil-to-lymphocyte ratio with the presence and complexity of coronary artery disease: an observational study. Anadolu Kardiyol Derg. 2013 Nov;13(7):662-7. 26. Sari I, Sunbul M, Mammadov C, et al. Relation of neutrophil-to-lymphocyte and platelet-to- lymphocyte ratio with coronary artery disease severity in patients undergoing coronary angiography. Kardiol Pol. 2015;73(12):1310-6. 27. Angkananard T, Anothaisintawee T, McEvoy M, et al. Neutrophil Lymphocyte Ratio and Cardiovascular Disease Risk: A Systematic Review and Meta-Analysis. Biomed Res Int. 2018 Nov 11;2018:2703518. 28. Rusnak J, Fastner C, Behnes M, et al. Biomarkers in Stable Coronary Artery Disease. Curr Pharm Biotechnol. 2017;18(6):456-471. 29. Hudzik B, Szkodziński J, Lekston A, et al. Mean platelet volume-to-lymphocyte ratio: a novel marker of poor short- and long-term prognosis in patients with diabetes mellitus and acute myocardial infarction. J Diabetes Complications. 2016 Aug;30(6):1097-102. 30. Shin DH, Rhee SY, Jeon HJ, et al. An Increase in Mean Platelet Volume/Platelet Count Ratio Is Associated with Vascular Access Failure in Hemodialysis Patients. PLoS One. 2017 Jan 17;12(1):e0170357.

STABİL KORONER ARTER HASTALIĞI OLAN YAŞLI ERKEKLERDE RUTİN İNFLAMATUAR MARKERLER VE EJEKSİYON FRAKSİYONU ARASINDAKİ İLİŞKİ

Year 2020, Volume: 53 Issue: 3, 165 - 170, 31.12.2020
https://doi.org/10.20492/aeahtd.668894

Abstract

Amaç: Son zamanlarda kronik inflamatuar hastalıklar için bazı inflamatuar belirteçler önerilmiştir. İnflamasyon, stabil koroner arter hastalığının (SKAH) patogenezinde önemli bir rol oynar. Çalışmamızın amacı, SKAH olan yaşlı erkek hastalarda hematolojik ve biyokimyasal inflamatuvar parametreleri değerlendirmektir.
Yöntemler: Mart 2015 ve Ağustos 2019 tarihleri arasında, 3 ay boyunca efor anjina olan, koroner anjiyografide 3 damar hastalığı olan ve transtorasik ekokardiyogramda ejeksiyon fraksiyonu (EF) %55'den az olan 65 yaş üstü 131 erkek hasta birinci çalışma grubuna dahil edildi. En az 3 aydan fazla efor anjinası olan, koroner anjiografide 3 damar hastalığı tespit edilen ve transtorasik ekokardiyogramda EF% 55'nin üzerinde olan, 65 yaş üstü 117 erkek hasta ikinci çalışma grubuna dahil edildi. Yaşlı erkek hastaların verileri, kurumun hasta dosyalarından kaydedildi. İki çalışma grubunun verileri karşılaştırıldı.
Bulgular: Grup 1' de, Red Cell Distribution Width (RDW), Mean Plattelet Volüm (MPV) / trombosit (P) ve RDW / P değerleri grup 2'den anlamlı olarak yüksekti (p <.01).
Sonuç: Yeni enflamatuar belirteçler düşük ejeksiyon fraksiyonu olan stabil koroner arter hastalığı olan yaşlı erkeklerde normal ejeksiyon fraksiyonu olanlardan daha yüksekti.

References

  • 1. Lang RM1, Bierig M, Devereux RB, et al. Chamber Quantification Writing Group; American Society of Echocardiography’s Guidelines and Standards Committee; European Association of Echocardiography. Recommendations for chamber quantification: a report from the American Society of Echocardiography’s Guidelines and Standards Committee and the Chamber Quantification Writing Group, developed in conjunction with the European Association of Echocardiography, a branch of the European Society of Cardiology. J Am Soc Echocardiogr 2005;18:1440–1463. 2. Yancy CW, Jessup M, Bozkurt B, et al; American College of Cardiology Foundation. American Heart Association Task Force on Practice Guidelines 2013 ACCF/AHA guideline for the management of heart failure: A report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol 2013;62:e147–e239. 3. Packard RR, Libby P. Inflammation in atherosclerosis: from vascular biology to biomarker discovery and risk prediction. Clin Chem. 2008;54(1):24-38. 4. Kinlay S, Ganz P. Role of endothelial dysfunction in coronary artery disease and implications for therapy. Am J Cardiol. 1997; 80(9A):11I-16I. 5. Satilmis Bilgin, Gulali Aktas, M. Zahid Kocak, et al: Association between novel inflammatory markers derived from hemogram indices and metabolic parameters in type 2 diabetic men, The Aging Male, 2019; DOI: 10.1080/13685538.2019.1632283 6. Motomura T, Shirabe K, Mano Y, et al. Neutrophil lymphocyte ratio reflects hepatocellular carcinoma recurrence after liver transplantation via inflammatory microenvironment. J Hepatol. 2013;58:58–64. 7. Fu H, Qin B, Hu Z, et al. Neutrophil- and platelet-to lymphocyte ratios are correlated with disease activity in rheumatoid arthritis. Clin Lab. 2015;61:269–273. 8. Kocak MZ, Aktas G, Erkus E, et al. Mean platelet volume to lymphocyte ratio as a novel marker for diabetic nephropathy. J Coll Physicians Surg Pak. 2018; 28:844–847. 9. Gasparyan AY, Sandoo A, Stavropoulos-Kalinoglou A, et al. Mean platelet volume in patients with rheumatoid arthritis: the effect of anti-TNF-alpha therapy. Rheumatol Int. 2010;30:1125–1129. 10. Dagistan Y, Dagistan E, Gezici AR, et al. Could red cell distribution width and mean platelet volume be a predictor for lumbar disc hernias? Ideggyogy Szemle. 2016;69:411–414. 11. Aktas G, Sit M, Karagoz I, et al. Could red cell distribution width be marker of thyroid cancer? J Coll Physicians Surg Pak. 2017;27:556–558. 12. Osman Sönmez, Gökhan Erta§, Ahmet Bacaksizet al. Relation of neutrophil -to- lymphocyte ratio with the presence and complexity of coronary artery disease: an observational study. Anadolu Kardiyol Derg. 2013 Nov;13(7):662-7. 13. Lloyd-Jones DM, Larson MG, Leip EP, et al; Framingham Heart Study. Lifetime risk for developing congestive heart failure: the Framingham Heart Study. Circulation 2002;106:3068– 3072. 14. Alderman EL, Bourassa MG, Cohen LS, et al Ten-year follow-up of survival and myocardial infarction in the randomized Coronary Artery Surgery Study. Circulation 1990;82:1629–1646. 15. Simonsen JA, Johansen A, Gerke O, et al. Outcome with invasive versus medical treatment of stable coronary artery disease: influence of perfusion defect size, ischemia, and ejection fraction. EuroIntervention. 2016;11(10):1118-24. 16. Libby R Ridker PM, Maseri A. Inflammation and atherosclerosis. Circulation 2002; 105:1135-43. 17. Packard RR, Libby P. Inflammation in atherosclerosis: from vascular biology to biomarker discovery and risk prediction. Clin Chem. 2008;54(1):24-38). 18. Kinlay S, Ganz P. Role of endothelial dysfunction in coronary artery disease and implications for therapy. Am J Cardiol. 1997; 80(9A):11I-16I. 19. Chen H, Ding X, Li J, et al. White blood cell count: an independent predictor of coronary heart disease risk in middle-aged and elderly population with hyperuricemia. Medicine (Baltimore). 2018 Dec;97(51):e13729. 20. Orakzai SH1, Orakzai RH, Nasir K, Carvalho JA, Blumenthal RS, Santos RD. Relationship between white blood cell count and Framingham Risk Score in asymptomatic men. Arch Med Res. 2007 May;38(4):386-91. 21. Gillum RF, Mussolino ME, Madans JH. Counts of neutrophils, lymphocytes, and monocytes, cause-specific mortality and coronary heart disease: the NHANES-I epidemiologic follow-up study. Ann Epidemiol. 2005 Apr;15(4):266-71. 22. Sansanayudh N, Anothaisintawee T, Muntham D, et al, Thakkinstian A. Mean platelet volume and coronary artery disease: a systematic review and meta-analysis. Int J Cardiol. 2014 Aug 20;175(3):433-40. 23. Wada H, Dohi T, Miyauchi K, et al. Mean platelet volume and long-term cardiovascular outcomes in patients with stable coronary artery disease. Atherosclerosis. 2018 Oct;277:108-112. 24. Sincer I, Gunes Y, Mansiroglu AK, et al. Association of mean platelet volume and red blood cell distribution width with coronary collateral development in stable coronary artery disease. Postepy Kardiol Interwencyjnej. 2018;14(3):263-269. 25. Sönmez O, Ertaş G, Bacaksız Aet al. Relation of neutrophil-to-lymphocyte ratio with the presence and complexity of coronary artery disease: an observational study. Anadolu Kardiyol Derg. 2013 Nov;13(7):662-7. 26. Sari I, Sunbul M, Mammadov C, et al. Relation of neutrophil-to-lymphocyte and platelet-to- lymphocyte ratio with coronary artery disease severity in patients undergoing coronary angiography. Kardiol Pol. 2015;73(12):1310-6. 27. Angkananard T, Anothaisintawee T, McEvoy M, et al. Neutrophil Lymphocyte Ratio and Cardiovascular Disease Risk: A Systematic Review and Meta-Analysis. Biomed Res Int. 2018 Nov 11;2018:2703518. 28. Rusnak J, Fastner C, Behnes M, et al. Biomarkers in Stable Coronary Artery Disease. Curr Pharm Biotechnol. 2017;18(6):456-471. 29. Hudzik B, Szkodziński J, Lekston A, et al. Mean platelet volume-to-lymphocyte ratio: a novel marker of poor short- and long-term prognosis in patients with diabetes mellitus and acute myocardial infarction. J Diabetes Complications. 2016 Aug;30(6):1097-102. 30. Shin DH, Rhee SY, Jeon HJ, et al. An Increase in Mean Platelet Volume/Platelet Count Ratio Is Associated with Vascular Access Failure in Hemodialysis Patients. PLoS One. 2017 Jan 17;12(1):e0170357.
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Details

Primary Language English
Subjects Health Care Administration
Journal Section Original research article
Authors

Ayhan Coşgun

Publication Date December 31, 2020
Submission Date January 1, 2020
Published in Issue Year 2020 Volume: 53 Issue: 3

Cite

AMA Coşgun A. RELATIONSHIP BETWEEN ROUTINE INFLAMMATORY MARKERS AND EJECTION FRACTION IN ELDERLY MEN WITH STABLE CORONARY ARTERY DISEASE. Ankara Eğitim ve Araştırma Hastanesi Tıp Dergisi. December 2020;53(3):165-170. doi:10.20492/aeahtd.668894