EVALUATION OF ATOPIC STATUS IN PATIENTS WITH PRIMARY SJOGREN’S SYNDROME

Year 2020, Volume: 53 Issue: 3, 142 - 147, 31.12.2020

Selcan Gültuna , Seçil Kepil Cem Özişler

https://doi.org/10.20492/aeahtd.704879

Abstract

Purpose: The prevalence of atopy has been investigated in different autoimmune diseases in various studies. But, the atopic status in primary Sjögren’s syndrome (pSS) patients has not been evaluated yet. We aimed to determine the relationship between pSS and atopy.
Material and Method: Fifty consecutive adult patients with pSS and fifty age and sex-matched controls were prospectively recruited in this study pSS patients were evaluated with laboratory tests and disease activity score. All subjects underwent skin prick test to a standard panel of common aeroallergens.
Results: Ten patients (10/50, 20%) in the pSS group and five patients (6/50, 12%) in the control group had positivity on skin prick tests with common inhalant allergens (p=0.267). No significant differences were found regarding the clinical characteristics between atopic and non-atopic pSS patients.
Conclusions: Atopic status and allergen sensitization were evaluated in pSS patients. To our knowledge, this is the first study investigating the inhalen allergen spectrum in pSS patients. The prevalence of atopy is similar in patients with pSS to the controls. But atopy may be related to milder clinical manifestations of pSS.

Keywords

Allergy, atopy, Sjögren’s syndrome

Supporting Institution

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Primer Sjögren Sendromunda Atopik Durumun Değerlendirilmesi

Abstract

Giriş: Çeşitli otoimmün hastalıklarda atopi prevalansı çeşitli çalışmalarda araştırılmıştır. Ancak primer Sjögren’in sendromu (pSS) hastalarındaki atopik durum henüz değerlendirilmemiştir. PSS ve atopi arasındaki ilişkiyi belirlemeyi amaçladık.
Gereç ve Yöntem: PSS tanısı almış elli erişkin hasta ve elli yaş ve cinsiyet uyumlu kontroller prospektif olarak bu çalışmaya alındı ve pSS hastaları laboratuvar testleri ve hastalık aktivite skoru ile değerlendirildi. Tüm katılımcılara standart inhalen panel ile deri prik testi uygulandı.
Bulgular: PSS grubunda 10 hastada (10/50, %20) ve kontrol grubunda beş hastada (6/50, %12) deri prik testi pozitif bulundu (p = 0.267). Atopik ve atopik olmayan pSS hastaları arasında klinik özellikler açısından anlamlı fark bulunmadı.
Sonuç: PSS hastalarında atopik durum ve alerjen duyarlılığı değerlendirildi. Literatür bilgimize göre, pSS hastalarında inhale alerjen spektrumunu araştıran ilk çalışmadır. Atopi prevalansı pSS'li hastalarda kontrollere benzer bulundu. Ancak atopi, pSS'nin ılımlı klinik bulgular ile ilişkili olabilir.

Keywords

Atopi, allerji, sjögren sendromu

References

• 1. D’Angelo G, Marseglia L, Manti S, Colavita L, Cuppari, et al. Atopy and autoimmune thyroid diseases: melatonin can be useful? Ital J pediatr. 42(1), 95 (2016). https://doi.org/10.1186/s13052-016-0305-0.
• 2. Berker M, Frank LJ, Geβner AL, Grassl N, Holtermann AV, et al. Allergies - A T cells perspective in the era beyond the TH1/TH2 paradigm. Clin Immunol. 174, 73-83 (2017). https://doi.org/10.1016/ j.clim. 2016. 11.001.
• 3. Rabin RL, Levinson AI. The nexus between atopic disease and autoimmunity: a review of the epidemiological and mechanistic literature. Clin Exp Immunol. 153(1), 19–30 (2008). https://doi.org/1010.1111/j.1365-2249.2008.03679.x.
• 4. Sackesen C, Bakkaloglu A, Sekerel BE, Ozaltin F, Besbas N, et al. Decreased prevalence of atopy in paediatric patients with familial Mediterranean fever. Ann Rheum Dis. 63(2), 187–190 (2004). https:// doi. org /1010.1136/ard.2003.007013.
• 5. Allanore Y, Hilliquin P, Coste J, Renoux M, Menkes CJ. Decreased prevalence of atopy in rheumatoid arthritis. Lancet. 351(9101), 497 (1998).
• 6. Aydoğmuş Ç, Ayaz NA, Çakan M, Çipe F, Topal N, et al. Is there any difference regarding atopy between children with Familial Mediterranean fever and healthy controls? Allergol Immunopathol (Madr). 45(6), 549 – 552 (2017). https://doi.org /10.1016/ j.aller. 2016. 12.006.
• 7. Chen X, Wu H, Wei W. Advances in the diagnosis and treatment of Sjögren’s syndrome. Clin Rheumatol. 37(7), 1743-1749 (2018). https://doi.org/10.1007/s10067-018-4153-8.
• 8. Patel R, Shahane A. The epidemiology of Sjögren’s syndrome. Clin Epidemiol. 6, 247-255 (2014). https://doi.org/10.2147/CLEP.S47399.
• 9. Verstappen GM, Corneth OBJ, Bootsma H, Kroese FGM. Th17 cells in primary Sjögren’S syndrome: Patogenicity and plasticity. J Autoimmun. 87, 16-25 (2018). https://doi.org/ 10. 1016/ j.jaut.2017.11.003.
• 10. Kolkowski EC, Reth P, Pelusa F, Bosch J, Pujol-Borrell R, et al. Th1 predominance and perforin expression in minor salivary glands from patients with primary Sjögren’s syndrome. J Autoimmun. 13(1), 155-162 (1999).
• 11. Pertovaara M, Antonen J, Hurme M. Th2 cytokine genotypes are associated with a milder form of primary Sjögren’s syndrome. Ann Rheum Dis. 65(5), 666-670 (2006).
• 12. Jabs DA, Lee B, Whittum-Hudson JA, Prendergast RA. Th1 versus Th2 immune responses in autoimmune lacrimal gland diseases in MRL/Mp mice. Invest Ophthalmol Vis Sci. 41(3), 826–831 (2004).
• 13. Akpek EK, Jabs DA, Gerard HC, Prendergast RA, Hudson AP, et al. Chemokines in autoimmune lacrimal gland disease in MRL/Mp mice. Invest Ophthalmol Vis Sci. 45(1), 185–190 (2000).
• 14. Shiboski CH, Shiboski SC, Seror R, Criswell LA, Labetoulle M, et al. 2016 American College of Rheumatology/ European League Against Rheumatism classification criteria for primary Sjögren's syndrome: A consensus and data-driven methodology involving three international patient cohorts. Ann Rheum Dis. 76(1), 9-16 (2017). https://doi.org/ 10.1136/annrheumdis 2016-210571.
• 15. Seror R, Bootsma H, Saraux A, Bowman SJ, Theander E, et al. Defining disease activity states and clinically meaningful improvement in primary Sjögren's syndrome with EULAR primary Sjögren's syndrome disease activity (ESSDAI) and patient-reported indexes (ESSPRI). Ann Rheum Dis. 75(2), 382–389 (2016). https:// doi.org/ 10.1136 / ann rheumdis-2014-206008.
• 16. Guo R, Zhou Y, Lu L, Cao L, Cao J. Atopy in children with juvenile systemic lupus erythematosus is associated with severe disease. PLoS One. 12, 5:e0177774 (2017). https:// doi.org/10.1371/journal.pone.0177774.
• 17. Huo Y, Hu HY, Liu IL, Chang YT, Wu CY. The risk of autoimmune connective tissue diseases in patients with atopy: A nationwide population-based cohort study. Allergy Asthma Proc. 38(5), 383-389 (2017). https://doi.org/10.2500/aap.2017.38.4071.
• 18. Shen TC, Chen HJ, Wei CC, Chen CH, Tu CY, et al. Risk of asthma in patients with primary Sjögren’s syndrome: a retrospective cohort study. BMC Pulmonary Medicine. 16(1), 152 (2016). https://doi.org/10.1186/s12890-016-0312-3.
• 19. Fairfax AJ, Haslam PL, Pavia D, Sheahan NF, Bateman JR, et al. Pulmonary disorders associated with Sjögren’s syndrome. Q J Med. 50(199), 279–295 (1981).
• 20. Kang JH, Lin HC. Comorbidities in patients with primary Sjogren’s syndrome: a registry-based case-control study. J Rheumatol. 37(6), 1188–1194 (2010). https://doi.org/ 10.3899/jrheum.090942.
• 21. Şahiner UM, Civelek E, Yavuz ST, Büyüktiryaki AB, Tuncer A,et al. Skin Prick Testing to Aeroallergen Extracts: What is the Optimal Panel in Children and Adolescents in Turkey? Int Arch Allergy Immunol. 157(4), 391-398 (2012). https://doi.org/10.1159/000329870.
• 22. Platts-Mills TA, Woodfolk JA. Allergens and their role in the allergic immune response. Immunol Rev. 242(1), 51-68 (2011). https://doi.org/10.1111/j.1600-065X.2011.01021.x.
• 23.Ciprandi G, Cirillo I. Monosensitization and Polysensitization in allergic rhinitis. Eur J Intern Med. 22(6), e75-9 (2011). https://doi.org/10.1016/j.ejim.2011.05.009