KOLESTEATOM VARLIĞININ ÖNGÖRÜLEBİLMESİNDE KANDAKİ NÖTROFİL/LENFOSİT ORANININ ÖNEMİ

Year 2021, Volume: 54 Issue: 3, 419 - 423, 01.01.2022

Hasan Çanakcı Kamil Gokce Tulacı

https://doi.org/10.20492/aeahtd.810162

Abstract

AMAÇ: Son yıllarda nötrofil/lenfosit oranı (NLO), platelet/lenfosit oranı (PLO) ve lenfosit/monosit oranı (LMO) oranları inflamasyonun bir göstergesi olarak çeşitli hastalıkların tanı ve takibinde kullanılmaktadır. Çalışmamızda da kronik otit hastalarında, inflamasyonla yakından ilişkili olduğu gösterilmiş olan kolesteatomun NLO, PLO ve LMO ile ilişkisinin incelenmesi amaçlanmıştır.
GEREÇ ve YÖNTEM: Kliniğimizde 2013-2019 yılları arasında kronik otit nedeniyle ameliyat edilen 138 hastanın dosyaları retrospektif olarak incelendi. Hastalar grup 1: kolesteatomlu kronik otit, grup 2: kolesteatomsuz kronik otit olarak sınıflandırıldı. Tüm hastaların yaş, cinsiyet, NLO, PLO, LMO verileri incelenerek kaydedildi ve gruplar arasında karşılaştırıldı.
BULGULAR: Grup 1’de 61 grup 2’de 77 hasta vardı. Gruplar arasında yaş ortalamaları açısından fark yoktu. Grup 1’de bayan hasta oranı grup 2 ye oranla daha düşüktü (p=0,042). Gruplar arasında kan hücrelerinin birbirine oranları incelendiğinde NLO, grup 1'de grup 2'ye göre anlamlı düzeyde yüksek izlenirken (p=0,006), PLO ve LMO da gruplar arasında istatistiksel açıdan anlamlı fark izlenmedi (sırasıyla p=0,913, p=0,111). NLO ≥1,734 kesme (cut-off) değeri, kolesteatom varlığını göstermede %75,4 duyarlılık ve %46,8 özgüllükte anlamlı olarak izlendi.
SONUÇ: Çalışmamızda farklı hastalıkların tanı ve takiplerinde inflamasyon göstergesi olarak anlamlı bilgiler verdiği gösterilen NLO’nın kolesteatom varlığını tahmin etmede de anlamlı olduğu görülmüştür. Kronik otit ve eşlik eden retraksiyon, adezyon veya sık enfeksiyon şikâyeti olan ve timpanoplasti sonrası nüks veya rezidü kolesteatom açısından risk taşıyan bireylerin takiplerinde NLO’nın değerlendirilmesinin hastaların takipleri açısından faydalı olabileceğini düşünmekteyiz.

Keywords

Kolesteatom, Nötrofil, Lenfosit, kronik otitis media

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