Assessment of Olfactory Functions in Patients with Acne vulgaris Under Systemic Treatment: A Prospective Study

Year 2024, Volume: 57 Issue: 3, 124 - 128, 22.01.2025

Nermin Karaosmanoğlu , Özge Mine Örenay , Pınar Özdemir Çetinkaya , Arcan Kıvanç Çapçı , Berkay Temel , Özlem Akkoca , Gökçe Özel , Rahmi Kılıç

https://doi.org/10.20492/aeahtd.1552508

Abstract

Aim: The loss of smell is a common disease and can affect a patient’s quality of life. Olfactory disturbance leads to problems such as safety and eating. Acne vulgaris is a prevalent disease in the daily clinical practice of a dermatologist. Doxycycline and isotretinoin are the most preferred systemic drugs for severe acne. This study aimed to investigate the possible effects on olfactory function in patients with acne vulgaris receiving isotretinoin and doxycycline therapy by using the Brief Smell Identification Test.
Material and Method: A total of 60 patients with acne vulgaris were included in the study. The patients were divided into two groups, each consisting of 30 patients. One group received oral doxycycline, while the other received oral isotretinoin. The olfactory function of each patient in both groups was assessed at the beginning and third month of treatment by using the Brief Smell Identification Test.
Results: There was no statistically significant difference between the total scores of the Brief Smell Identification Test at 0. and 3. months in both the isotretinoin group and the doxycycline group.
Conclusion: The results of the present study showed that both drugs are safe and have no undesirable effect on olfactory function. However, the certain effects of both drugs on olfactory functions still remain unknown. New studies are needed to shed light on this issue.

Keywords

acne, isotretinoin, doxycycline, olfactory functions, smell

Sistemik Tedavi Alan Akne Vulgaris Hastalarında Koku Fonksiyonlarının Değerlendirilmesi: Prospektif Bir Çalışma

Abstract

Amaç: Koku kaybı sık görülen bir hastalıktır ve hastanın yaşam kalitesini etkileyebilir. Koku alma bozukluğu hastaların günlük hayatında güvenlik ve yeme gibi sorunlara yol açar. Akne vulgaris, bir dermatoloğun günlük klinik pratiğinde sık görülen bir hastalıktır. Doksisiklin ve isotretinoin, şiddetli akne için en çok tercih edilen sistemik ilaçlardır. Bu çalışmada, ‘Brief Smell Identification Test’ kullanılarak isotretinoin ve doksisiklin tedavisi alan akne vulgarisli hastalarda koku alma fonksiyonu üzerindeki olası etkiler araştırılmıştır.
Gereç ve Yöntem: Çalışmaya toplam 60 akne vulgaris hastası dahil edildi. Hastalar her biri 30 hastadan oluşan iki gruba ayrıldı. Bir grup oral doksisiklin alırken, diğer grup oral isotretinoin aldı. Her iki gruptaki her hastanın koku alma fonksiyonu, tedavi başlangıcında ve üçüncü ayda ‘Brief Smell Identification Test’ kullanılarak değerlendirildi.
Bulgular: Hem isotretinoin grubunda hem de doksisiklin grubunda 0. ve 3. aylardaki ‘Brief Smell Identification Test’toplam skorları arasında istatistiksel olarak anlamlı bir fark yoktu.
Sonuç: Mevcut çalışmanın sonuçları her iki ilacın da güvenli olduğunu ve koku alma fonksiyonu üzerinde istenmeyen bir etkisinin olmadığını göstermiştir. Ancak her iki ilacın da koku alma fonksiyonları üzerindeki kesin etkileri hala bilinmemektedir. Bu konunun aydınlatılabilmesi için yeni çalışmalara ihtiyaç vardır.

Keywords

akne, izotretinoin, doksisiklin, koku fonksiyonu

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