Research Article
BibTex RIS Cite

Three-year outcomes of ophthalmological examinations performed at 0–3 months of term/late-preterm infants

Year 2025, Volume: 58 Issue: 2, 60 - 65, 29.08.2025
https://doi.org/10.20492/aeahtd.1625571

Abstract

Abstract
Objective: To present the ocular findings detected in babies with gestational ages >34 weeks in the ophthalmology outpatient clinic, as well as determine the frequency of these findings and their relationship with various variables, using data covering a span of three years.
Metods: The outcomes of the vision screening performed in 7,820 term/late preterm infants aged 0–3 months who were examined at the ophthalmology outpatient clinic of Zeynep Kamil Maternity and Children’s Diseases Training and Research Hospital between 2015 and 2017 were analyzed in this retrospective, cross-sectional, observational, and descriptive study.
Results: A total of 7,820 term and late-preterm infants were examined. An ocular finding was identified in 20.1% (n=1,569) of the infants. Retinal hemorrhage was detected as the most common finding in 9.5% (n=740) of the infants, and it was more common in infants who were ≤28 days than those who were 28 days post-natal (p<0.001). Immature vascularization (4.4%; n=346) and conjunctivitis (4.0%; n=313) were the other more common ocular findings.
Conclusions: Abnormal ocular findings, including disorders that could be components of a systemic disease and could cause loss of vision, were identified in 20.1% of the infants. The first three months of life comprises the period of visual function evolution. Therefore, an ophthalmological examination should be performed on all newborns before discharge or as soon as possible after discharge for the early diagnosis and timely management of abnormal findings.
Keywords: Eye screening, newborn screening, eye examination, cataract, retinal hemorrhage

References

  • 1. Altunhan H, Yılmaz FH. Yenidoğanın değerlendirilmesi ve yenidoğan taramaları [Neonatal Evaluation and Newborn Screenings]. Turkiye Klinikleri J Fam Med-Special Topics. 2018;9(1):28-32.
  • 2. American Academy of Pediatrics; Section on Ophthalmology; American Association for Pediatric Ophthalmology And Strabismus; American Academy of Ophthalmology; American Association of Certified Orthoptists. Red reflex examination in neonates, infants, and children [published correction appears in Pediatrics. 2009 Apr;123(4):1254]. Pediatrics. 2008;122(6):1401-1404. doi:10.1542/peds.2008-2624
  • 3. Committee on Practice and Ambulatory Medicine, Section on Ophthalmology. American Association of Certified Orthoptists; American Association for Pediatric Ophthalmology and Strabismus; American Academy of Ophthalmology. Eye examination in infants, children, and young adults by pediatricians. Pediatrics. 2003;111(4 Pt 1):902-907.
  • 4. Eventov-Friedman S, Leiba H, Flidel-Rimon O, Juster-Reicher A, Shinwell ES. The red reflex examination in neonates: an efficient tool for early diagnosis of congenital ocular diseases. Isr Med Assoc J. 2010;12(5):259-261.
  • 5. Sun M, Ma A, Li F, et al. Sensitivity and Specificity of Red Reflex Test in Newborn Eye Screening. J Pediatr. 2016;179:192- 196.e4. doi:10.1016/j.jpeds.2016.08.048
  • 6. Li LH, Li N, Zhao JY, et al. Findings of perinatal ocular examination performed on 3573, healthy full-term newborns. Br J Ophthalmol. 2013;97(5):588-591. doi:10.1136/bjophthalmol- 2012-302539
  • 7. Ekinci DY, Celik K. Awareness of retinopathy of prematurity among parents in Turkey. Retina-Vitreus/J Retina-Vitreous. 2020;29:214-9.
  • 8. Khan AO, Al-Mesfer S. Lack of efficacy of dilated screening for retinoblastoma. J Pediatr Ophthalmol Strabismus. 2005;42(4):205-234. doi:10.3928/01913913-20050701-01
  • 9. Vinekar A, Govindaraj I, Jayadev C, et al. Universal ocular screening of 1021 term infants using wide-field digital imaging in a single public hospital in India - a pilot study. Acta Ophthalmol. 2015;93(5):e372-e376. doi:10.1111/aos.12685
  • 10. Ma Y, Deng G, Ma J, Liu J, Li S, Lu H. Universal ocular screening of 481 infants using wide-field digital imaging system. BMC Ophthalmol. 2018;18(1):283. Published 2018 Oct 30. doi:10.1186/ s12886-018-0943-7
  • 11. Tang H, Li N, Li Z, et al. Fundus examination of 199 851 newborns by digital imaging in China: a multicentre cross-sectional study. Br J Ophthalmol. 2018;102(12):1742-1746. doi:10.1136/ bjophthalmol-2018-312366
  • 12. Türk Neonataloji Derneği. Türkiye Prematüre Retinopatisi Rehberi 2021 Güncellemesi.
  • 13. Fei P, Liu Z, He L, et al. Early detection of ocular abnormalities in a Chinese multicentre neonatal eye screening programme- 1-year result. Acta Ophthalmol. 2021;99(3):e415-e422. doi:10.1111/aos.14586
  • 14. Li LH, Wu WC, Li N, et al. Full-Term Neonatal Ophthalmic Screening in China: A Review of 4-Year Outcomes. Ophthalmic Surg Lasers Imaging Retina. 2017;48(12):983-992. doi:10.3928/23258160-20171130-05
  • 15. Chen F, Cheng D, Pan J, et al. The efficacy and safety of Retcam in detecting neonatal retinal hemorrhages. BMC Ophthalmol. 2018;18(1):202. Published 2018 Aug 20. doi:10.1186/s12886- 018-0887-y 65
  • 16. Perilli R, Lanci M, Romanzo A, Sabatini L, Fusilli P. Screening eye diseases in babies: an Italian experience on 5000 healthy, consecutive newborns. Ann Ist Super Sanita. 2015;51(4):387-389. doi:10.4415/ANN_15_04_22
  • 17. Teow Kheng Leong K, Abu Kassim SNA, Sidhu JK, et al. Neonatal eye screening for 203 healthy term new-borns using a wide-field digital retinal imaging system. BMC Ophthalmol. 2021;21(1):128. Published 2021 Mar 9. doi:10.1186/s12886-021- 01882-x
  • 18. Nayak S, Padhi TR, Mettla AL, Khanna RC. Universal eye screening: perinatal risk factors and ocular abnormalities in 1795 newborns not meeting retinopathy of prematurity criteria. Eye (Lond). 2024;38(11):2216-2223. doi:10.1038/s41433-024- 03162-6

Term/geç preterm bebeklerin 0-3 aylıkken yapılan göz muayenelerinin üç yıllık sonuçları

Year 2025, Volume: 58 Issue: 2, 60 - 65, 29.08.2025
https://doi.org/10.20492/aeahtd.1625571

Abstract

Özet
Amaç: Üç yıllık bir süreyi kapsayan verileri kullanarak, göz hastalıkları polikliniğinde gebelik yaşı >34 hafta olan bebeklerde tespit edilen göz bulgularını sunmak ve bu bulguların sıklığını ve çeşitli değişkenlerle ilişkilerini belirlemek.
Gereç ve Yöntem: 2015-2017 yılları arasında Zeynep Kamil Kadın Doğum ve Çocuk Hastalıkları Eğitim ve Araştırma Hastanesi göz hastalıkları polikliniğinde muayene edilen 0-3 aylık 7.820 term/geç preterm bebeğe yapılan görme taramasının sonuçları bu retrospektif, kesitsel, gözlemsel ve tanımlayıcı çalışmada analiz edildi.
Bulgular: Toplam 7.820 term ve geç preterm bebek muayene edildi. Bebeklerin %20,1'inde (n=1.569) göz bulgusu tespit edildi. Bebeklerin %9,5'inde (n=740) en sık görülen bulgu retina kanamasıydı ve ≤28 günlük bebeklerde doğumdan 28 gün sonra olanlara göre daha sıktı (p<0,001). İmmatür vaskülarizasyon (%4,4; n=346) ve konjonktivit (%4,0; n=313) diğer daha sık görülen göz bulgularıydı.
Sonuç: Sistemik bir hastalığın bileşeni olabilen ve görme kaybına neden olabilen bozukluklar da dahil olmak üzere anormal göz bulguları bebeklerin %20,1'inde belirlendi. Yaşamın ilk üç ayı görsel fonksiyon evriminin dönemini kapsar. Bu nedenle, anormal bulguların erken teşhisi ve zamanında yönetimi için tüm yenidoğanlara taburcu olmadan önce veya taburcu olduktan hemen sonra oftalmolojik muayene yapılmalıdır.
Anahtar kelimeler: Göz taraması, yenidoğan taraması, göz muayenesi, katarakt, retina kanaması

Ethical Statement

yazarlar arasında çıkar çatışması yoktur.

Supporting Institution

Destekleyen kurum yoktur.

References

  • 1. Altunhan H, Yılmaz FH. Yenidoğanın değerlendirilmesi ve yenidoğan taramaları [Neonatal Evaluation and Newborn Screenings]. Turkiye Klinikleri J Fam Med-Special Topics. 2018;9(1):28-32.
  • 2. American Academy of Pediatrics; Section on Ophthalmology; American Association for Pediatric Ophthalmology And Strabismus; American Academy of Ophthalmology; American Association of Certified Orthoptists. Red reflex examination in neonates, infants, and children [published correction appears in Pediatrics. 2009 Apr;123(4):1254]. Pediatrics. 2008;122(6):1401-1404. doi:10.1542/peds.2008-2624
  • 3. Committee on Practice and Ambulatory Medicine, Section on Ophthalmology. American Association of Certified Orthoptists; American Association for Pediatric Ophthalmology and Strabismus; American Academy of Ophthalmology. Eye examination in infants, children, and young adults by pediatricians. Pediatrics. 2003;111(4 Pt 1):902-907.
  • 4. Eventov-Friedman S, Leiba H, Flidel-Rimon O, Juster-Reicher A, Shinwell ES. The red reflex examination in neonates: an efficient tool for early diagnosis of congenital ocular diseases. Isr Med Assoc J. 2010;12(5):259-261.
  • 5. Sun M, Ma A, Li F, et al. Sensitivity and Specificity of Red Reflex Test in Newborn Eye Screening. J Pediatr. 2016;179:192- 196.e4. doi:10.1016/j.jpeds.2016.08.048
  • 6. Li LH, Li N, Zhao JY, et al. Findings of perinatal ocular examination performed on 3573, healthy full-term newborns. Br J Ophthalmol. 2013;97(5):588-591. doi:10.1136/bjophthalmol- 2012-302539
  • 7. Ekinci DY, Celik K. Awareness of retinopathy of prematurity among parents in Turkey. Retina-Vitreus/J Retina-Vitreous. 2020;29:214-9.
  • 8. Khan AO, Al-Mesfer S. Lack of efficacy of dilated screening for retinoblastoma. J Pediatr Ophthalmol Strabismus. 2005;42(4):205-234. doi:10.3928/01913913-20050701-01
  • 9. Vinekar A, Govindaraj I, Jayadev C, et al. Universal ocular screening of 1021 term infants using wide-field digital imaging in a single public hospital in India - a pilot study. Acta Ophthalmol. 2015;93(5):e372-e376. doi:10.1111/aos.12685
  • 10. Ma Y, Deng G, Ma J, Liu J, Li S, Lu H. Universal ocular screening of 481 infants using wide-field digital imaging system. BMC Ophthalmol. 2018;18(1):283. Published 2018 Oct 30. doi:10.1186/ s12886-018-0943-7
  • 11. Tang H, Li N, Li Z, et al. Fundus examination of 199 851 newborns by digital imaging in China: a multicentre cross-sectional study. Br J Ophthalmol. 2018;102(12):1742-1746. doi:10.1136/ bjophthalmol-2018-312366
  • 12. Türk Neonataloji Derneği. Türkiye Prematüre Retinopatisi Rehberi 2021 Güncellemesi.
  • 13. Fei P, Liu Z, He L, et al. Early detection of ocular abnormalities in a Chinese multicentre neonatal eye screening programme- 1-year result. Acta Ophthalmol. 2021;99(3):e415-e422. doi:10.1111/aos.14586
  • 14. Li LH, Wu WC, Li N, et al. Full-Term Neonatal Ophthalmic Screening in China: A Review of 4-Year Outcomes. Ophthalmic Surg Lasers Imaging Retina. 2017;48(12):983-992. doi:10.3928/23258160-20171130-05
  • 15. Chen F, Cheng D, Pan J, et al. The efficacy and safety of Retcam in detecting neonatal retinal hemorrhages. BMC Ophthalmol. 2018;18(1):202. Published 2018 Aug 20. doi:10.1186/s12886- 018-0887-y 65
  • 16. Perilli R, Lanci M, Romanzo A, Sabatini L, Fusilli P. Screening eye diseases in babies: an Italian experience on 5000 healthy, consecutive newborns. Ann Ist Super Sanita. 2015;51(4):387-389. doi:10.4415/ANN_15_04_22
  • 17. Teow Kheng Leong K, Abu Kassim SNA, Sidhu JK, et al. Neonatal eye screening for 203 healthy term new-borns using a wide-field digital retinal imaging system. BMC Ophthalmol. 2021;21(1):128. Published 2021 Mar 9. doi:10.1186/s12886-021- 01882-x
  • 18. Nayak S, Padhi TR, Mettla AL, Khanna RC. Universal eye screening: perinatal risk factors and ocular abnormalities in 1795 newborns not meeting retinopathy of prematurity criteria. Eye (Lond). 2024;38(11):2216-2223. doi:10.1038/s41433-024- 03162-6
There are 18 citations in total.

Details

Primary Language Turkish
Subjects Neonatology, Vision Science
Journal Section Original research article
Authors

Nurşah Yeniay Süt 0000-0002-8079-7990

Gökhan Çelik 0000-0003-2111-0420

Osman Kızılay 0000-0002-0948-3550

Güner Karatekin 0000-0001-7112-0323

Derya Büyükayhan 0000-0001-7172-0812

Publication Date August 29, 2025
Submission Date January 23, 2025
Acceptance Date July 13, 2025
Published in Issue Year 2025 Volume: 58 Issue: 2

Cite

AMA Yeniay Süt N, Çelik G, Kızılay O, Karatekin G, Büyükayhan D. Term/geç preterm bebeklerin 0-3 aylıkken yapılan göz muayenelerinin üç yıllık sonuçları. Ankara Eğitim ve Araştırma Hastanesi Tıp Dergisi. August 2025;58(2):60-65. doi:10.20492/aeahtd.1625571