Can the de Ritis Ratio (AST/ALT) Be Used to Predict Colon Cancer Stages?

Year 2023, , 140 - 144, 07.08.2023

Saygın Altıner , Enes Cebeci , Bedri Burak Sucu Mert Çöl Ender Ergüder , Yılmaz Ünal , Salih Tuncal , Mevlüt Recep Pekcici

https://doi.org/10.46332/aemj.1077653

Abstract

Purpose: The De Ritis ratio (Aspartate transaminase/alanine transaminase) is a critical prognostic factor for some kinds of malignant tumors. Nevertheless, the De Ritis ratio’s prognostic value in preoperative colon cancer staging is unclear. The purpose of this research was to determine the De Ritis ratio and its prognostic significance for colon cancer.

Materials and Methods: The clinicopathological data of 271 individuals with malign colon cancer were analyzed retrospectively at a single center from January 2010 to January 2018. The relationship between the De Ritis coefficient and clinicopathological findings in patients was evaluated before treatment. To compare the groups, the Mann-Whitney U test and the Kruskal Wallis test were performed.

Results: The results indicated that there were no statistically significant differences between the groups in terms of pre-treatment De Ritis ratio assessment as a staging, localization, tumor diameter, lymph node metastasis, age, and overall survival. However, differences in T staging between groups of male participants were shown to be statistically significant.

Conclusions: The De Ritis ratio evaluation before treatment was not found as an independent variable prognostic factor for the diagnosis and staging of colon cancer. However, future studies may demonstrate the significance of the De Ritis ratio with more participants.

Keywords

adenocarcinoma, survival, prognosis

De Ritis Oranı (AST/ALT) Kolon Kanseri Evrelerini Tahmin Etmek Için Kullanılabilir Mi?

Abstract

Amaç: De Ritis oranı (Aspartat transaminaz/alanin transaminaz), bazı malign tümör türleri için kritik bir prognostik faktördür. Bununla birlikte, ameliyat öncesi kolon kanseri evrelemesinde De Ritis oranının prognostik değeri belirsizdir. Bu araştırmanın amacı kolon kanserinde De Ritis oranını ve kolon kanseri için prognostik önemini belirlemektir.

Araçlar ve Yöntem: Ocak 2010'dan Ocak 2018'e kadar tek merkezde malign kolon kanserli 271 bireyin klinikopatolojik verileri geriye dönük olarak analiz edildi. Ameliyat öncesi dönemde hastaların De Ritis oranı ile klinikopatolojik bulguları arasındaki ilişki değerlendirildi. Grupları karşılaştırmak için Mann-Whitney U testi ve Kruskal Wallis testi yapıldı.

Bulgular: Sonuçlar, tedavi öncesi De Ritis oranı değerlendirmesi açısından evreleme, lokalizasyon, tümör çapı, lenf nodu metastazı, yaş ve genel sağkalım açısından gruplar arasında istatistiksel olarak anlamlı bir fark olmadığını gösterdi. Bununla birlikte erkek hastalar arasındaki T evrelemesindeki farklılıkların istatistiksel olarak anlamlı olduğu gösterildi.

Sonuç: Tedavi öncesi değerlendirilen De Ritis oranı kolon kanseri tanı ve evrelemesinde bağımsız bir değişken prognostik faktör değildi. Bununla birlikte, gelecekteki çalışmalar, daha fazla katılımcıyla De Ritis oranının önemini gösterebilir.

Keywords

adenokarsinom, sağkalım, prognoz

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