Predictive Value of Inflammatory Biomarkers, Nutritional Status and Vitamin D in Postoperative Outcomes After Sleeve Gastrectomy

Emre Ballı; Fatih Gürsoy

doi:10.46332/aemj.1908590

Predictive Value of Inflammatory Biomarkers, Nutritional Status and Vitamin D in Postoperative Outcomes After Sleeve Gastrectomy

Abstract

Purpose: This study aimed to assess how well preoperative systemic inflammation markers, the prognostic nutritional index (PNI), and blood vitamin D [25(OH)D] levels predict short-term postsurgical issues following laparoscopic sleeve gastrectomy (LSG).

Materials and Methods: The analysis of the data of 383 LSG patients was performed. Preoperative data consisted of neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), PNI, and 25(OH)D measurements. To find independent complication predictors, we ran univariate and multivariate logistic regressions. Because of multicollinearity among inflammatory indices, the final model retained only NLR. Evaluation of the predictive accuracy and clinical usefulness was carried out with the receiver operating characteristic (ROC) and decision curve analyses.

Results: Twenty-three patients (6.0%) developed early complications. On univariate analysis, elevated NLR, PLR, and SII, as well as reduced PNI and 25(OH)D levels, correlated with complication occurrence. Multivariate analysis identified NLR (OR = 1.85, 95% CI: 1.22–2.81, p=0.004) and male sex (OR = 2.45, 95% CI: 1.10–5.46, p=0.028) as independent predictors; vitamin D showed no such association (p=0.19). ROC analysis revealed NLR as the strongest predictor (AUC = 0.84), followed by PLR (AUC = 0.78); PNI and vitamin D displayed only modest discriminative ability. The multivariable model showed good performance (AUC = 0.86).

Conclusion: Preoperative NLR and male sex independently predict early postoperative complications after LSG. NLR is a simple biomarker that may enhance preoperative risk assessment. Although PNI and 25(OH)D were not independent predictors, they remain clinically relevant for patient optimization.

Keywords

Supporting Institution

The authors declare that there was no financial support for this study

Ethical Statement

This study was approved by the Non-Interventional Clinical Research Ethics Committee of Afyonkarahisar Health Sciences University (Meeting No: 2025/6, Approval Date: May 2, 2025). This study was conducted in accordance with the Declaration of Helsinki, and informed consent was obtained from eligible participants. All clinical data were anonymized prior to analysis, and no identifiable personal information was included. Given the retrospective nature of this study and the use of de-identified data, the requirement for informed consent was waived by the Ethics Committee of the Afyonkarahisar University of Health Sciences.

Thanks

Not applicable.

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Details

Primary Language

English

Subjects

Clinical Sciences (Other)

Journal Section

Research Article

Authors

Emre Ballı ^*
0000-0002-3201-9756
Türkiye

Fatih Gürsoy
0000-0001-8299-494X
Türkiye

Publication Date

August 31, 2026

Submission Date

March 12, 2026

Acceptance Date

May 15, 2026

Published in Issue

Year 2026 Volume: 10 Number: 2

DOI

https://doi.org/10.46332/aemj.1908590

IZ

https://izlik.org/JA84CN59GY

Cite

RIS / Bibtex

APA

Ballı, E., & Gürsoy, F. (2026). Predictive Value of Inflammatory Biomarkers, Nutritional Status and Vitamin D in Postoperative Outcomes After Sleeve Gastrectomy. Ahi Evran Medical Journal, 10(2), 246-255. https://doi.org/10.46332/aemj.1908590

AMA

1.Ballı E, Gürsoy F. Predictive Value of Inflammatory Biomarkers, Nutritional Status and Vitamin D in Postoperative Outcomes After Sleeve Gastrectomy. Ahi Evran Med J. 2026;10(2):246-255. doi:10.46332/aemj.1908590

Chicago

Ballı, Emre, and Fatih Gürsoy. 2026. “Predictive Value of Inflammatory Biomarkers, Nutritional Status and Vitamin D in Postoperative Outcomes After Sleeve Gastrectomy”. Ahi Evran Medical Journal 10 (2): 246-55. https://doi.org/10.46332/aemj.1908590.

EndNote

Ballı E, Gürsoy F (August 1, 2026) Predictive Value of Inflammatory Biomarkers, Nutritional Status and Vitamin D in Postoperative Outcomes After Sleeve Gastrectomy. Ahi Evran Medical Journal 10 2 246–255.

IEEE

[1]E. Ballı and F. Gürsoy, “Predictive Value of Inflammatory Biomarkers, Nutritional Status and Vitamin D in Postoperative Outcomes After Sleeve Gastrectomy”, Ahi Evran Med J, vol. 10, no. 2, pp. 246–255, Aug. 2026, doi: 10.46332/aemj.1908590.

ISNAD

Ballı, Emre - Gürsoy, Fatih. “Predictive Value of Inflammatory Biomarkers, Nutritional Status and Vitamin D in Postoperative Outcomes After Sleeve Gastrectomy”. Ahi Evran Medical Journal 10/2 (August 1, 2026): 246-255. https://doi.org/10.46332/aemj.1908590.

JAMA

1.Ballı E, Gürsoy F. Predictive Value of Inflammatory Biomarkers, Nutritional Status and Vitamin D in Postoperative Outcomes After Sleeve Gastrectomy. Ahi Evran Med J. 2026;10:246–255.

MLA

Ballı, Emre, and Fatih Gürsoy. “Predictive Value of Inflammatory Biomarkers, Nutritional Status and Vitamin D in Postoperative Outcomes After Sleeve Gastrectomy”. Ahi Evran Medical Journal, vol. 10, no. 2, Aug. 2026, pp. 246-55, doi:10.46332/aemj.1908590.

Vancouver

1.Emre Ballı, Fatih Gürsoy. Predictive Value of Inflammatory Biomarkers, Nutritional Status and Vitamin D in Postoperative Outcomes After Sleeve Gastrectomy. Ahi Evran Med J. 2026 Aug. 1;10(2):246-55. doi:10.46332/aemj.1908590