Does Phlebotomy for Donor Purposes in Healthy People have Effects on Total Oxidant and Total Antioxidant levels?

Abstract

Purpose: In this study, we aimed to evaluate the possible long-term effects of phlebotomy on body oxidant and antioxidant system in healthy people.

Materials and Methods: This prospective study included 30 healthy volunteers (15 men and 15 women) who applied to donate blood to the Red Crescent Blood Center. Total antioxidant capacity, total oxidant status, oxidative stress index, hemoglobin, unsaturated iron binding capacity, iron and ferritin levels were measured before the phlebotomy and on the 14th day following the procedure.

Results: The levels of total antioxidant capacity, total oxidant status, oxidative stress index, hemoglobin, unsaturated iron binding capacity, and iron values showed no statistically significant difference before and after the procedure (p> 0.05). Hemoglobin and ferritin values showed statistically significant difference before and after the procedure.

Conclusion: It seems that single-season phlebotomy has no long-term effect on the body total oxidant and antioxidant levels. 

Keywords

• oxidative stress
• iron
• phlebotomy

Sağlıklı İnsanlarda Donör Amaçlı Yapılan Flebotominin Total Oksidan ve Total Antioksidan Düzeylere Etkisi Var mıdır?

Abstract

Amaç: Bu çalışmada, sağlıklı kişilerde yapılan flebotomi işleminin uzun dönemde vücut oksidan ve antioksidan sistem üzerindeki olası etkilerinin değerlendirilmesi amaçlanmıştır.

Araçlar ve Yöntem: Bu çalışma prospektif olarak tasarlanmış olup, çalışmaya Kızılay Kan Merkezine donör amaçlı kan bağışında bulunmak için başvuran sağlıklı ve gönüllü 30 kişi (15 erkek 15 kadın) dâhil edilmiştir. Flebotomi işlemi öncesinde ve işlemden sonraki 14. günde total antioksidan seviye, total oksidan seviye, oksidatif stres indeksi, hemoglobin, doymamış demir baglama kapasitesi, demir ve ferritin düzeyleri ölçüldü.

Bulgular: İşlem öncesi ve işlemden sonraki 14. günde total antioksidan seviye, total oksidan seviye, oksidatif stres indeksi, hemoglobin, doymamış demir baglama kapasitesi ve demir değerleri istatistiksel olarak anlamlı değildi (p>0.05). İşlemden önceki hemoglobin ve ferritin değerleri ile 14. gündeki değerler anlamlı bulundu (p<0.001).

Sonuç: Tek defa yapılan flebotomi işleminin uzun dönemde vücut total oksidan ve total antioksidan düzeylerine etkisinin olmadığı görünmektedir.

Keywords

• oksidatif stres
• demir
• flebotomi

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