Immunosuppressive Medication Adherence in Liver Transplant Patients: A Single Center Experience

Abstract

Purpose: This study aimed to determine immunosuppressive medication adherence in patients with liver transplant.

Materials and Methods: This cross-sectional, descriptive study was conducted between December 2018 and Septem-ber 2019 in the Hacettepe University Liver Transplantation Center. A total of 31 patients who had liver transplanta-tion in this center were included in the study. Data of the study were obtained using "Immunosuppressive Therapy Adherence Scale" and "Immunosuppressive Medication Adherence Scale".

Results: The mean scores of the Immunosuppressive Medication Adherence Scale and the Immunosuppressive Thera-py Adherence Scale was 48.10 ± 6.61 and 10.90 ± 1.16, respectively. According to the scores obtained from both scales, it was determined that 13% of the participants had low immunosuppressive medication adherence. A signifi-cant negative correlation was found between the mean score of the Immunosuppressive Medication Adherence Scale and the time after transplantation (r=-0.437; p=0.016). A statistically significant relationship was found between the mean score of the Immunosuppressive Treatment Adherence Scale and the working status of the participants (t=-2.357; p=0.026).

Conclusion: We are of opinion that immunosuppressive medication adherence in liver transplant patients should be evaluated with various measurement tools and, liver transplantation centers need to develop methods and strategies to improve medication adherence according to the patient requirements.

Keywords

• immunosuppressive agents
• liver transplantation
• medication adherence
• medication nonadherence

Karaciğer Transplantasyonu Yapılan Hastalarda İmmünsupresif İlaç Kullanımına Uyum: Tek Merkez Deneyimi

Abstract

Amaç: Bu çalışma karaciğer transplantasyonu yapılan hastalarda immünsupresif ilaç kullanımına uyumu belirlemek amacıyla yapılmıştır.

Araçlar ve Yöntem: Bu kesitsel-tanımlayıcı araştırma, Hacettepe Üniversitesi Karaciğer Nakil Merkezi’nde Aralık 2018- Eylül 2019 tarihleri arasında yürütülmüştür. Çalışmaya bu merkezde karaciğer transplantasyonu yapılmış olan 31 hasta dahil edilmiştir. Çalışma verileri “İmmünosupresif Tedaviye Uyum Ölçeği” ve “İmmünsupresif İlaç Kullanı-mına Uyum Ölçeği” kullanılarak elde edilmiştir.

Bulgular: Katılımcıların İmmünsupresif İlaç Kullanımına Uyum Ölçeği puan ortalaması 48.10±6.61 ve İmmünosup-resif Tedaviye Uyum Ölçeği puan ortalaması 10.90±1.16 olarak bulunmuştur. Her iki ölçekten elde edilen puanlara göre katılımcıların %13’ünün immünsupresif ilaç kullanımına uyumunun düşük olduğu saptanmıştır. İmmünsupresif İlaç Kullanımına Uyum Ölçeği puanları ile transplantasyon sonrası geçen süre arasında negatif yönde anlamlı bir ilişki saptanmıştır (r=-0.437, p=0.016). Katılımcıların İmmünosupresif Tedaviye Uyum Ölçeği puanları ile çalışma durumu arasında istatistiksel olarak anlamlı bir ilişki bulunmuştur (t=-2.357; p=0.026).

Sonuç: Karaciğer transplantasyon merkezlerinin, transplantasyon yapılan hastalarda immünsupresif ilaç kullanımına uyumunun çeşitli ölçüm araçları ile değerlendirilerek hasta gereksinimleri doğrultusunda uyumu iyileştirecek yöntem ve stratejiler geliştirilmesinin gerekli olduğunu düşünüyoruz.

Keywords

• immünsupresif ajan
• karaciğer nakli
• tedaviye uyum
• tedaviye uyumsuzluk

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