Investigation of Outer Hair Cell Function of the Cochlea in Psoriasis Patients

Abstract

Purpose: Psoriasis has been accepted as a T-cell mediated systemic disease and systemic inflammation may also cause immune-mediated hearing loss. We aimed to evaluate cochlear function with otoacoustic emission (OAE) measurement in psoriasis pa-tients and to evaluate whether there is a relationship between duration and severity of the disease and OAEs.
Materials and Methods: Forty-four patients diagnosed with psoriasis were included in the study. The control group consisted of 35 healthy volunteers. The patients' age, gender, onset age, family history, disease duration, and additional diseases were ques-tioned, and psoriasis area severity index (PASI) was calculated. Audiological and otological evaluations were performed. Distor-tion Product Otoacoustic Emission (DPOAE) were measured at 500, 1000, 2,000, 4,000, 6000, 8000 and 10000 Hz frequencies.
Results: There was no significant difference in DPOAE values at 500, 1000, 2000, 4000, 6000, 8000, and 10000 Hz between healthy volunteers and psoriasis patients. There was a significant difference between PASI score and SNR value at 1000 Hz (p=0.031), disease duration, and DPAOE values at 4000 and 6000 Hz (p=0.033, p=0.038 respectively)
Conclusion: Considering that psoriasis is a long-term, chronic systemic disease, patients should be follow-up closely even if they do not have hearing complaints in the early period, and as the duration and severity of the disease increases, the hearing of the patients may be affected. 

Keywords

• Cochlea
• Otoacoustic emission
• Outer hair cell
• Psoriasis

Psöriazis Hastalarında Koklear Dış Tüy Hücre Fonksiyonunun Araştırılması

Abstract

Amaç: Psöriazis, T hücre aracılı sistemik bir hastalık olarak kabul edilmektedir ve sistemik inflamatur yanıt immun sistem aracılı işitme kaybına neden olabilir. Çalışmamızda, psoriazis hastalarında koklear fonksiyonunun göstergesi olan otoakustik emisyon (OAE) ölçümü ile hastalık süre ve şiddeti ile arasında bir ilişki olup olmadığını değerlendirmeyi amaçladık.
Araçlar ve Yöntem: Çalışmaya psoriasis tanılı 44 hasta dahil edildi. Kontrol grubu 35 sağlıklı gönüllüden oluşturuldu. Hastaların yaşı, cinsiyeti, hastalık başlangıç yaşı ve süresi, aile öyküsü ve ek hastalıkları sorgulandı ve psoriazis alan şiddet indeksi (PASI) hesaplandı. Odyolojik ve otolojik değerlendirmeler yapıldı. Distortion Product Otoakustik Emisyon (DPOAE) 500, 1000, 2000, 4000, 6000, 8000 ve 10000 Hz frekanslarında ölçüldü.
Bulgular: 500, 1000, 2000, 4000, 6000, 8000 ve 10000 Hz'deki DPOAE değerleri karşılaştırıldığında hasta grubu ile sağlıklı gönüllüler arasında anlamlı fark yoktu. PASI skoru ile 1000 Hz'deki SNR değeri arasında (p=0.031) ve hastalık süresi ile 4000 ve 6000 Hz'deki DPAOE değerleri arasında (sırasıyla p=0.033, p=0.038 anlamlı fark bulundu.
Sonuç: Psöriazisin uzun süreli, kronik sistemik bir hastalık olduğu göz önüne alındığında, hastaların erken dönemde işitme yakınmaları olmasa dahi yakından takip edilmesi önemlidir ve hastalığın süresi ve şiddeti arttıkça hastaların işitme duyusu etkilenebilir.

Keywords

• Dış tüy hücreleri
• Otoakustik emisyon
• Koklea
• Psoriazis

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