Kronik Ürtiker Hastalarında Fibromiyalji Sendromu Sıklığının Değerlendirilmesi

Abstract

Amaç: Kronik ürtiker, nedeni tam olarak aydınlatılamamış kaşıntılı bir deri hastalığıdır. Otoimmünite ve psikojenik faktörlerin de patogenezde rolü olabileceği düşünülmektedir. Fibromiyalji sendromu (FMS) psikojenik nedenlerle ilişkili olabileceği düşünülen bir romatizmal hastalıktır. Çalışmamızda kronik ürtiker hastalarında FMS sıklığı ve şiddetini araştırmayı ve kronik ürtikere eşlik eden fibromiyalji varlığının klinik özelliklere ve dermatoloji yaşam kalitesine etkisini değerlendirmeyi planladık.

Araçlar ve Yöntem: Çalışmaya kronik ürtiker tanısı almış ve sistemik hastalık öyküsü olmayan 100 hasta, yaş ve cinsiyet açısından eşleştirilmiş 100 sağlıklı kontrol dahil edildi. Ürtiker şiddeti dermatoloji yaşam kalite indeksi skorları (DYKI) hesaplanarak değerlendirildi. Klinik şiddet ve fonksiyonel disabilite durumları vizuel analog skala (VAS) ve fibromiyalji etki anketi (FIQ) ile değerlendirildi.

Bulgular: Hasta grubunun yaş ortalaması 37.7±1.32, kontrol grubunun ise 40.7±11.2 olarak saptandı (p=0.09). Hasta grubundaki FMS sıklığı (%45) kontrol grubundan (%13) istatistiksel olarak anlamlı şekilde yüksekti (p=0.00). Kronik ürtiker süresi FMS'li hastalarda istatistiksel olarak anlamlı derecede yüksek bulundu(p=0.001). FIQ ve DLQI değerleri arasında istatistiksel olarak anlamlı korelasyon saptandı (p=0.019). Hasta ve kontrol grubunda FMS süreleri, VAS ve FIQ açısından istatistiksel olarak anlamlı fark saptanmadı (p=0.432, p=0.201, p=0.332).

Sonuç: Kronik ürtiker hastalarında FMS sıklığının artmış olduğunu görülmektedir. Bu sonuç kronik ürtiker patogenezindeki nöromediatörlerin kronik dönemdeki etkileriyle ilişkili olabilir.

Keywords

• fibromiyalji
• kaşıntı
• kronik ürtiker
• nörojenik inflamasyon
• yaşam kalitesi

Evaluation of Fibromyalgia Frequency in Chronic Urticaria Patients and Its Association with Urticaria Severity

Abstract

Purpose: Chronic urticaria is a skin disease with unknown etiology. Autoimmunity and psychogenic factors have been suggested to play a role in pathogenesis. Fibromyalgia is a rheumatic disease that may be associated with psychogenic factors. The aim of the study was to determine the frequency and severity of fibromyalgia and the effect of fibromyalgia coexistence on clinical features and dermatology life quality index in urticaria patients.

Materials and Methods: One hundred patients with chronic urticaria and no history of any systemic disease and 100 age and sexmatched healthy controls were included. Urticaria severity was evaluated by the dermatology life quality index (DLQI). Clinical severity and disability status were evaluated by the visual analog scale (VAS) and fibromyalgia impact questionnaire (FIQ).

Results: The mean age of the chronic urticaria patient group was 37.7±1.32, and that was 40.7±11.2 in the control group (p=0.09). Fibromyalgia frequency (45%) in the chronic urticaria group was significantly higher than in the control group (13%) (p=0.00). The duration of chronic urticaria was significantly higher in the patients with FMS than in the patients without FMS (p=0.001). There was a statistically significant correlation between FIQ and DLQI (p=0.019). No significant differences in terms of FMS durations, VAS, and FIQ values were detected between groups (p=0.432, p=0.201, p=0.332).

Conclusion: High frequency of fibromyalgia in chronic urticaria patients was found. This may be related to the chronic effect of neuromediators involved in chronic urticaria pathogenesis. 

Keywords

• chronic urticaria
• fibromiyalgia
• neurogenic inflammation
• pruritus
• quality of life

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