Akut COVID-19 Hastalarında Bilişsel Değerlendirme: Kesitsel Bir Çalışma

Year 2023, Volume: 7 Issue: 3, 364 - 370, 20.12.2023

Yusuf Koçak , Asuman Çelikbilek , Burc Esra Sahin , Duygu Zorlu , Gökmen Zararsız

https://doi.org/10.46332/aemj.1264653

Abstract

Amaç: COVID-19’a bağlı kognitif bozukluk daha önce yapılan çalışmalarda yüksek oranda bildirilmiştir. Enfeksiyonun ilk solunum semptomlarından sonraki 5 gün içinde, hafif COVID-19 hastalarında, COVID-19 olmayan hastalara kıyasla, Montreal Bilişsel Değerlendirmesini (MoCA) kullanarak bilişsel işlevleri araştırıldı.

Araçlar ve Yöntem: Bu prospektif kesitsel çalışmaya hafif COVID-19'lu 113 hasta ve yaş ve cinsiyet olarak eşleştirilmiş 109 kontrol alındı. Bilişsel işlevler, MoCA kullanılarak değerlendirildi.

Bulgular: MoCA skorlarının COVID-19 hastalarında kontrollere göre anlamlı derecede düşük olduğunu bulduk (P<0.001). Kontrollerle karşılaştırıldığında, görsel uzamsal (P<0.001), bellek (P=0.017) ve dikkat (P<0.048) alanları gibi bazı MoCA öğelerinde puan kayıpları bulduk. Çok değişkenli modelde kadın cinsiyet (2.06 [1.02–4.16], P=0.044), düşük eğitim düzeyi (15.05 [5.16–43.90], P<0.001), yüksek açlık kan şekeri düzeyi (0.98 [0.96–1.00]), P=0.043) ve COVID-19 (24.24 [9.52–61.72], P<0.001) varlığı bağımsız olarak kognitif bozuklukla ilişkiliyidi (OR, %95 CI).

Sonuç: Hafif COVID-19'lu hastalarda akut faz sırasında görsel uzamsal, bellek ve dikkat alanlarında bilişsel işlev bozukluğu tespit edildi.

Keywords

COVID-19, biliş, bilişsel değerlendirme, montreal bilişsel değerlendirme, salgın

Cognitive Assessment in Patients with Acute COVID-19: A Cross-Sectional Study

Abstract

Purpose: Many reports have revealed a high percentage of patients suffering from cognitive impairment due to COVID-19. We investigated cognitive functions using the Montreal Cognitive Assessment (MoCA) in mild COVID-19 patients compared with non-COVID-19 patients within 5 days after the initial respiratory symptoms of infection.

Materials and Methods: 113 patients with mild COVID-19 and 109 age- and sex-matched controls were enrolled in this prospective cross-sectional study. Cognitive functions were evaluated using the MoCA.

Results: We found that the MoCA scores were significantly lower in the COVID-19 patients than in the controls (P<0.001). Compared to the controls, we found point deficits within some MoCA items such as visuospatial (P<0.001), memory (P=0.017), and attention (P<0.048) domains. In the multivariate model, female sex (2.06 [1.02–4.16], P=0.044), low education level (150.05 [5.16–43.90], P<0.001), high fasting blood glucose level (0.98 [0.96–1.00], P=0.043), and the presence of COVID-19 (24.24 [9.52–61.72], P<0.001) were independently associated with cognitive impairment (OR, 95% CI).

Conclusion: We detected cognitive dysfunction, involving the visuospatial domain, memory, and attention, during the acute phase in patients with mild COVID-19.

Keywords

COVID-19, cognition, cognitive assessment, montreal cognitive assessment, pandemic

Thanks

Dear Editor, We are submitting our manuscript entitled ‘Cognitive assessment in patients with acute COVID-19: A cross-sectional study’ to Ahi Evran Medical Journal for publication after all the authors (Yusuf Kocak, Asuman Celikbilek, Burc Esra Sahin, Duygu Zorlu, Gokmen Zararsiz) have seen and approved the final form of it. We confirm that this manuscript has been submitted solely to this journal and is not published, in press, or submitted elsewhere. The following address can be used for any kind of negotiations. We appreciate if you could consider our manuscript for publication in Ahi Evran Medical Journal. Best wishes, Dr. Asuman Celikbilek Corresponding Author: Asuman Celikbilek, Prof, MD Kirsehir Ahi Evran University, Faculty of Medicine, Department of Neurology 40100, Kirsehir, Turkey ORCID: 0000-0002-2367-1128 Telephone: [phone] Fax: [phone] E-mail: [e-mail] Dear Editor, We are submitting our manuscript entitled ‘Cognitive assessment in patients with acute COVID-19: A cross-sectional study’ to Ahi Evran Medical Journal for publication after all the authors (Yusuf Kocak, Asuman Celikbilek, Burc Esra Sahin, Duygu Zorlu, Gokmen Zararsiz) have seen and approved the final form of it. We confirm that this manuscript has been submitted solely to this journal and is not published, in press, or submitted elsewhere. The following address can be used for any kind of negotiations. We appreciate if you could consider our manuscript for publication in Ahi Evran Medical Journal. Best wishes, Dr. Asuman Celikbilek Corresponding Author: Asuman Celikbilek, Prof, MD Kirsehir Ahi Evran University, Faculty of Medicine, Department of Neurology 40100, Kirsehir, Turkey ORCID: 0000-0002-2367-1128 Telephone: [phone] Fax: [phone] E-mail: [e-mail]

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