Evaluation of antifungal activities of the ethalolic extract of the macrofungus Suillus collinitus against dermatophytes

Abstract

In this study, the ethanolic crude extracts obtained from the macrofungus Suillus collinitus (Fr.) O. Kuntze (Suillaceae, Bolatales) were investigated for their antifungal activities against dermatophytes such as the isolates Microsporum gypseum, Trichophyton rubrum and Epidermophyton floccosum by the agar well diffusion method as well as tube dilution method. The ethanol extracts have a strong effect with mean values zone of inhibition at different concentrations and a wide zone of inhibition was determined at 1500 mg/mL (20.8 mm) for M. gypseum, (18.2 mm) for T. rubrum and (16.8 mm) for E. floccosum. MIC of M. gyspseum at 50 µg/mL, MIC of T. rubrum at 60 µg/mL and E. floccosum at 70 µg/mL were observed, respectively. Terbinafine as the comparison antifungal agent gave MIC values between 10 µg/mL for E. floccosum and T. rubrum and 20 µg/mL for M. gypseum. These findings against dermatophytes support our observations regarding the use of this macrofungus among the public. Besides, the findings of this screening study are a preliminary step to further pharmaceutical researches on the relevant macrofungus in the future.

Keywords

• Antifungal activity
• Dermatophytes
• Macrofungus
• Suillus collinitus

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